1-(2-Nitro-phenyl)-5-(2,6,6- trimethylcyclohex-2-enyl)-pent-1-en-3-one | 1093097-57-4

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: 1-(2-Nitro-phenyl)-5-(2,6,6- trimethylcyclohex-2-enyl)-pent-1-en-3-one
• 英文别名: (E)-1-(2-nitrophenyl)-5-(2,6,6-trimethylcyclohex-2-en-1-yl)pent-1-en-3-one
• CAS: 1093097-57-4
• 化学式: C₂₀H₂₅NO₃
• 分子量: 327.423
• InChiKey: OYQVUBLPTPIYLM-ZHACJKMWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  24
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  62.9
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  7,8-二氢紫罗兰酮 、 邻硝基苯甲醛 在 aluminum oxide 、 potassium fluoride 作用下， 反应 0.07h， 以69%的产率得到1-(2-Nitro-phenyl)-5-(2,6,6- trimethylcyclohex-2-enyl)-pent-1-en-3-one
  参考文献：
  名称：

  Chemotherapy of leishmaniasis part-VIII: Synthesis and bioevaluation of novel chalcones

  摘要：

  Some novel dihydro-a-ionone based chalcones have been synthesized and evaluated for their in vitro antileishmanial activity in promastigote and amastigote model. Some of the compounds showed 100% inhibition at 5 and 2 mu m/ml concentration. (C) 2008 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2007.12.014

文献信息

• Chemotherapy of leishmaniasis part-VIII: Synthesis and bioevaluation of novel chalcones
  作者：S.N. Suryawanshi、Naveen Chandra、Pawan Kumar、Jyoti Porwal、Suman Gupta

  DOI：10.1016/j.ejmech.2007.12.014

  日期：2008.11

  Some novel dihydro-a-ionone based chalcones have been synthesized and evaluated for their in vitro antileishmanial activity in promastigote and amastigote model. Some of the compounds showed 100% inhibition at 5 and 2 mu m/ml concentration. (C) 2008 Elsevier Masson SAS. All rights reserved.