丙二醇二辛酸酯/二癸酸酯 | 68583-51-7

• 物质功能分类: 有机原料 - 羧酸类化合物及衍生物 - 羧酸酯及其衍生物
• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 中文名称: 丙二醇二辛酸酯/二癸酸酯
• 中文别名: 辛癸酸丙二醇酯
• 英文名称: Decanoic acid;octanoic acid;propane-1,2-diol
• CAS: 68583-51-7
• 化学式: C21H44O6
• 分子量: 392.6
• InChiKey: YZWQUQVFVLJWCS-UHFFFAOYSA-N

物化性质

• LogP：
  3.965 (est)
• 物理描述：
  Liquid

计算性质

• 辛醇/水分配系数(LogP)：
  5.0
• 重原子数：
  27
• 可旋转键数：
  15
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.9
• 拓扑面积：
  115
• 氢给体数：
  4
• 氢受体数：
  6

安全信息

• WGK Germany：
  1

制备方法与用途

应用

丙二醇二辛酸酯/二癸酸酯可用作表面活性剂，在化妆品中作为皮肤调理剂和柔润剂。它具有出色的乳化、分散、增溶及润滑性能。

文献信息

• MEDICINAL SOLUTIONS
  申请人：Takeda Chemical Industries, Ltd.

  公开号：EP1374855A1

  公开（公告）日：2004-01-02

  The present invention relates to a pharmaceutical solution containing a physiologically active non-peptide substance, an organic acid and a biocompatible organic solvent, and provides a pharmaceutical solution wherein a physiologically active non-peptide substance is dissolved at a high concentration.

  本发明涉及一种含有生理活性非肽物质、有机酸和生物相容性有机溶剂的药物溶液，并提供了一种药物溶液，其中生理活性非肽物质以高浓度溶解。
• Medicinal solutions
  申请人：——

  公开号：US20040116522A1

  公开（公告）日：2004-06-17

  The present invention relates to a pharmaceutical solution containing a physiologically active non-peptide substance, an organic acid and a biocompatible organic solvent, and provides a pharmaceutical solution wherein a physiologically active non-peptide substance is dissolved at a high concentration.

  本发明涉及一种含有生理活性非肽物质、有机酸和生物相容性有机溶剂的药物溶液，并提供了一种药物溶液，其中生理活性非肽物质以高浓度溶解。
• PHARMACEUTICAL COMPOSITION FOR ORAL ADMINISTRATION OF A PYRAZOLE-3-CARBOXAMIDE DERIVATIVE
  申请人：BREUL Thierry

  公开号：US20090004261A1

  公开（公告）日：2009-01-01

  this invention discloses and claims a pharmaceutical composition in liquid or semi-liquid form, which is self-emulsifying or self-microemulsifying in aqueous medium, for the oral administration of a pyrazole-3-carboxamide derivative, in which said derivative is dissolved in an amphiphilic mixture containing one or more lipid solvents and a nonionic hydrophilic surfactant.

  本发明披露并声明了一种药物组合物，以液体或半液体形式存在，该组合物在水介质中自乳化或自微乳化，用于口服吡唑-3-羧酰胺衍生物，其中所述衍生物溶解在含有一种或多种脂溶剂和非离子亲水性表面活性剂的两亲混合物中。
• Dermal anti-inflammatory composition
  申请人：——

  公开号：US20020165286A1

  公开（公告）日：2002-11-07

  A pharmaceutical composition for dermal application comprises a lipophilic anti-inflammatory compound and a pharmaceutically acceptable vehicle comprising a lipophilic excipient capable of solubilizing the anti-inflammatory compound and targeting said compound to the pilosebaceous ducts on application of the composition on the skin. The composition may be used in the treatment of dermal inflammatory conditions, in particular acne.

  一种用于皮肤应用的制剂，包括一个亲脂性抗炎化合物和一种药学上可接受的载体，该载体包括一种亲脂性赋形剂，能够溶解抗炎化合物并将该化合物靶向应用于皮肤上的毛囊皮脂导管。该制剂可用于治疗皮肤炎症状况，特别是痤疮。
• Use of combinations comprising a corticosteroid and a pyrimidopyrimidine in the treatment of inflammatory diseases
  申请人：Combinatorx, Incorporated

  公开号：EP2070550A1

  公开（公告）日：2009-06-17

  The invention features a method for treating a patient diagnosed with, or at risk of developing, an immunoinflammatory disorder by administering to the patient a tetra-substituted pyrimidopyrimidine, either alone or in combination with one or more additional agents. The invention also features a composition containing a tetra-substituted pyrimidopyrimidine in combination with one or more additional agents.

  本发明的特点是通过向患者单独或与一种或多种附加制剂联合使用四取代嘧啶嘧啶，治疗被诊断患有或有可能患上免疫炎症性疾病的患者。本发明的另一个特点是含有四取代嘧啶嘧啶的组合物与一种或多种附加制剂的组合物。