2,5-bis(4'-isopropylbenzylidene)cyclopentanone

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: 2,5-bis(4'-isopropylbenzylidene)cyclopentanone
• 英文别名: 2,5-Bis[(4-propan-2-ylphenyl)methylidene]cyclopentan-1-one
• 化学式: C₂₅H₂₈O
• 分子量: 344.497
• InChiKey: BLRYANQKLDMIRG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.8
• 重原子数：
  26
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  环戊酮 、 4-异丙基苯甲醛 在 ash of pomegranate peels 作用下， 以 水 为溶剂， 反应 0.5h， 以90%的产率得到2,5-bis(4'-isopropylbenzylidene)cyclopentanone
  参考文献：
  名称：

  石榴皮灰（APP）：一种生物废物多相催化剂，用于可持续合成α，α'-双（取代苄基）环烷酮和2-芳基-1-丁酮

  摘要：

  摘要 以石榴皮（APP）的灰分为催化剂，由水中的各种取代的醛和环烷酮可高效制备α，α'-双（取代的亚苄基）环烷酮。通过简单的热处理将石榴果皮干燥即可从生物废料中获得APP催化剂，并通过FT-IR，XRD，XRF，EDX，SEM，DSC-TGA和BET技术证实了其活性相的形成。分析表明，本发明的催化剂具有促进所需产物合成的碱性位点。我们协议的主要吸引力是利用高度丰富的生物废物衍生催化剂，并在最短的反应时间内获得良好至优异的产率。通过在低温下将等摩尔量的芳族醛和1-四氢萘酮缩合，该绿色方案进一步扩展为结构上多样化的2-亚芳基-1-四氢萘酮。 图形摘要

  DOI：

  10.1007/s11164-020-04160-5

文献信息

• Second- and third-order nonlinear optical properties of bis-chalcone derivatives
  作者：M. Sai Kiran、Benoy Anand、S. Siva Sankara Sai、G. Nageswara Rao

  DOI：10.1016/j.jphotochem.2014.06.004

  日期：2014.9

  second- and third-order nonlinear optical properties of these samples are studied using second harmonic generation and nanosecond open-aperture Z-scan methods. CP-POME has shown a very high second harmonic generation (SHG) efficiency (5.3 times that of urea). These molecules reveal a strong third-order nonlinear absorption (NLA) that is of optical limiting type, due to their peculiar D–π–A–π–D structure

  双查尔酮衍生物：2,5-双（亚苄基）-环戊酮（CP-DBA），2,5-双（4-甲氧基-亚苄基）-环戊酮（CP-POME），2,5-双（4-异丙基）克莱森-施密特反应合成了-亚苄基）-环戊酮（CP-ISO）和2,5-双（肉桂基）-环戊酮（CP-CAL），并用FT-IR，1 H NMR，13进行了表征13 C NMR和质谱技术。使用二次谐波产生和纳秒开孔Z扫描方法研究了这些样品的二阶和三阶非线性光学性质。CP-POME已显示出很高的二次谐波生成（SHG）效率（是尿素的5.3倍）。这些分子由于其独特的D–π–A–π–D结构导致离域电子云的高度极化，因此显示出光学极限类型的强三阶非线性吸收（NLA）。CP-CAL表现出最高的NLA活性，β系数为1×10 -10  m / W。通过数值模拟，发现在所有样品的情况下，NLA的机理都是双光子吸收过程。
• Diarylidenecyclopentanone derivatives as potent anti-inflammatory and anticancer agents
  作者：Nitesh Tamang、Gayathri Ramamoorthy、Mayank Joshi、Angshuman Roy Choudury、Siva Kumar B.、Nageswara Rao Golakoti、Mukesh Doble

  DOI：10.1007/s00044-020-02578-5

  日期：2020.9

  Cancer is often associated with chronic inflammation. In order to develop potential anticancer and anti-inflammatory agents a series of 26 diarylidenecyclopentanones (DACPs) Ia–Iv, II, III, and IV were synthesized. Five of the synthesized DACPs are novel (Ih, Ij, Ik, Is, and Iv), derivative Iv was characterized using single-crystal X-ray diffraction study. All the synthesized derivatives were tested

  癌症通常与慢性炎症有关。为了开发潜在的抗癌药和抗炎药，合成了26种二芳基亚环戊酮（DACP）Ia-Iv，II，III和IV。合成的DACP中有五个是新颖的（Ih，Ij，Ik，Is和Iv），使用单晶X射线衍射研究表征了衍生物Iv。测试所有合成的衍生物的抗炎和细胞毒性。复合是通过抑制PGE 2（前列腺素E 2）的产生，发现其具有最高的抗炎活性（93.67％）。观察到三个DACP s（Io，It和Iu）具有很高的细胞毒性，对HeLa的IC 50值分别为8.73±0.06 µM（Io），12.55±0.31 µM（It）和11.47±0.15 µM（Iu）细胞。使用这三个DACP进行了进一步的染色和细胞周期分析，以了解其作用机理。观察到G 0 / G 1相是细胞经历凋亡的最长相。
• HOLOGRAM RECORDING COMPOSITION, HOLOGRAM RECORDING MEDIUM, DIFFRACTION OPTICAL ELEMENT, AND OPTICAL DEVICE, OPTICAL COMPONENT, AND IMAGE DISPLAY DEVICE IN WHICH DIFFRACTION OPTICAL ELEMENT IS USED
  申请人：Sony Group Corporation

  公开号：EP3896530A1

  公开（公告）日：2021-10-20

  To provide a hologram recording composition that can further improve diffraction characteristics and transparency of a hologram. The present technology provides a hologram recording composition containing a heteropoly acid, a photopolymerizable monomer, a photopolymerization initiator, and a sensitizing dye having absorption in a visible light region in the presence of an acid. The present technology also provides a hologram recording medium including at least a photocurable resin layer containing a heteropoly acid, a photopolymerizable monomer, a photopolymerization initiator, and a sensitizing dye having absorption in a visible light region in the presence of an acid. Furthermore, the present technology also provides a diffraction optical element using the hologram recording medium. Moreover, the present technology also provides an optical device, an optical component, and an image display device using the diffraction optical element.

  为了提供一种全息图记录组合物，该组合物能够进一步提高全息图的衍射特性和透明度。 本技术提供了一种全息图记录组合物，该组合物含有杂多酸、可光聚合单体、光聚合引发剂以及在酸存在下在可见光区域具有吸收性的敏化染料。本技术还提供了一种全息图记录介质，该介质至少包括一个光固化树脂层，该树脂层含有杂多酸、可光聚合单体、光聚合引发剂和在有酸存在时在可见光区域具有吸收性的敏化染料。此外，本技术还提供了一种使用全息图记录介质的衍射光学元件。此外，本技术还提供了使用该衍射光学元件的光学设备、光学元件和图像显示设备。
• HOLOGRAM RECORDING COMPOSITION, HOLOGRAM RECORDING MEDIUM, DIFFRACTION OPTICAL ELEMENT, AND OPTICAL DEVICE, OPTICAL COMPONENT, AND IMAGE DISPLAY DEVICE USING DIFFRACTION OPTICAL ELEMENT
  申请人：Sony Group Corporation

  公开号：US20220013142A1

  公开（公告）日：2022-01-13

  To provide a hologram recording composition that can further improve diffraction characteristics and transparency of a hologram. The present technology provides a hologram recording composition containing a heteropoly acid, a photopolymerizable monomer, a photopolymerization initiator, and a sensitizing dye having absorption in a visible light region in the presence of an acid. The present technology also provides a hologram recording medium including at least a photocurable resin layer containing a heteropoly acid, a photopolymerizable monomer, a photopolymerization initiator, and a sensitizing dye having absorption in a visible light region in the presence of an acid. Furthermore, the present technology also provides a diffraction optical element using the hologram recording medium. Moreover, the present technology also provides an optical device, an optical component, and an image display device using the diffraction optical element.
• Ash of pomegranate peels (APP): A bio-waste heterogeneous catalyst for sustainable synthesis of α,α′-bis(substituted benzylidine)cycloalkanones and 2-arylidene-1-tetralones
  作者：Rupesh C. Patil、Uttam P. Patil、Ashutosh A. Jagdale、Sachinkumar K. Shinde、Suresh S. Patil

  DOI：10.1007/s11164-020-04160-5

  日期：2020.7

  Abstract α,α′-bis(substituted benzylidene)cycloalkanones were efficiently prepared from variously substituted aldehydes and cycloalkanones in water by using ash of pomegranate peels (APP) as a catalyst. The APP-catalyst was obtained from bio-waste by simple thermal treatment to dry peels of pomegranate fruit and formation of its active phase was confirmed by FT-IR, XRD, XRF, EDX, SEM, DSC-TGA and BET

  摘要 以石榴皮（APP）的灰分为催化剂，由水中的各种取代的醛和环烷酮可高效制备α，α'-双（取代的亚苄基）环烷酮。通过简单的热处理将石榴果皮干燥即可从生物废料中获得APP催化剂，并通过FT-IR，XRD，XRF，EDX，SEM，DSC-TGA和BET技术证实了其活性相的形成。分析表明，本发明的催化剂具有促进所需产物合成的碱性位点。我们协议的主要吸引力是利用高度丰富的生物废物衍生催化剂，并在最短的反应时间内获得良好至优异的产率。通过在低温下将等摩尔量的芳族醛和1-四氢萘酮缩合，该绿色方案进一步扩展为结构上多样化的2-亚芳基-1-四氢萘酮。 图形摘要