S-farnesyl-5-chlorothiosalicylic acid

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: S-farnesyl-5-chlorothiosalicylic acid
• 英文别名: 5-chloro-2-(3,7,11-trimethyldodeca-2,6,10-trienylsulfanyl)benzoic acid
• 化学式: C₂₂H₂₉ClO₂S
• 分子量: 392.99
• InChiKey: BNENOULFKRUUQV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.8
• 重原子数：
  26
• 可旋转键数：
  10
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.41
• 拓扑面积：
  62.6
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  2-氨基-5-氯苯甲酸 在 盐酸 、 guanidine carbonate 、 sodium disulfide 、 溶剂黄146 、 锌 、 sodium nitrite 作用下， 以 丙酮 为溶剂， 生成 S-farnesyl-5-chlorothiosalicylic acid
  参考文献：
  名称：

  Novel inhibitors of the prenylated protein methyltransferase reveal distinctive structural requirements

  摘要：

  Inhibitors of a prenylated protein methyltransferase were synthesized and evaluated. S-farnesyl-5-fluorothiosalicylic acid and the 5-chloro analog (but not the 4-fluoro, 4-chloro or 3-chloro analogs) were potent inhibitors, as was the parent compound S-farnesyl thiosalicylic acid (FTS), whose methyl ester was far less active. S-geranyl and S-geranylgeranyl thiosalicylic acids were more than ten times less potent than FTS. (C) 1997 Elsevier Science Ltd.

  DOI：

  10.1016/s0960-894x(97)00294-1

文献信息

• Novel inhibitors of the prenylated protein methyltransferase reveal distinctive structural requirements
  作者：Daniele Marciano、Ziporet Aharonson、Tal Varsano、Roni Haklai、Yoel Kloog

  DOI：10.1016/s0960-894x(97)00294-1

  日期：1997.7

  Inhibitors of a prenylated protein methyltransferase were synthesized and evaluated. S-farnesyl-5-fluorothiosalicylic acid and the 5-chloro analog (but not the 4-fluoro, 4-chloro or 3-chloro analogs) were potent inhibitors, as was the parent compound S-farnesyl thiosalicylic acid (FTS), whose methyl ester was far less active. S-geranyl and S-geranylgeranyl thiosalicylic acids were more than ten times less potent than FTS. (C) 1997 Elsevier Science Ltd.