4-methoxy-2-pentanone

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 4-methoxy-2-pentanone
• 英文别名: (4R)-4-methoxypentan-2-one
• 化学式: C₆H₁₂O₂
• 分子量: 116.16
• InChiKey: BNEZGZQZWFYHTI-ZCFIWIBFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.2
• 重原子数：
  8
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  戊-3-炔-2-酮 在 palladium diacetate 、 Lindlar's catalyst 、 palladium dichloride 喹啉 、 高氯酸 、 水 、 氢气 、 2-蒎烯聚合物 、 9-硼双环[3.3.1]壬烷 、 对苯醌 、 lithium chloride 、 copper dichloride 作用下， 以 四氢呋喃 、 乙腈 为溶剂， 20.0~50.0 ℃ 、101.33 kPa 条件下， 反应 64.0h， 生成 4-methoxy-2-pentanone
  参考文献：
  名称：

  Palladium(II)-Catalyzed Exchange and Isomerization Reactions. 17. Exchange of Chiral Allyl Alcohols with Hydroxide, Methoxide, and Phenyl at High [Cl^-]. Stereochemistry of the Wacker Reaction

  摘要：

  At high [Cl-] (> 2.0 M), PdCl42- catalyzes the exchange of chiral allylic alcohols with hydroxy, methoxy, and phenyl to give chiral allyl-substituted olefins. With unsymmetrical olefins, isomerization occurs along with exchange. The hydroxyl exchange occurs in aqueous solution while the other exchanges are carried out in methanol solution. At low [Cl-] (0.1 M) oxidation to the corresponding beta-hydroxy-, methoxy-, and phenyl-substituted carbonyl compounds occurred. The absolute configurations of the oxidation and exchange products should be the same if the same mode of addition to the Pd(II)-pi-complex is operative. The absolute configurations of the oxidation and exchange products for the phenylation reaction were the same, while for hydroxy and methoxy they were different. This result indicates methanol and water must have different stereochemistries of addition at high and low [Cl-]. Thus, previous studies showing anti hydroxypalladation at high [Cl-] are not valid indicators of the stereochemistry at low [Cl-]. If anti addition occurs at high [Cl-], the addition must be syn at low [Cl-].

  DOI：

  10.1021/jo9906274

文献信息

• DITERPENOID MEMBRANOLIDE COMPOUNDS HAVING ANTI-LEISHMANIA ACTIVITY AND USES THEREOF
  申请人：BAKER BILL J.

  公开号：US20160030388A1

  公开（公告）日：2016-02-04

  In a screening program, the Antarctic sponge Dendrilla membranosa was found to produce diterpenoid secondary metabolites with activity against the leishmaniasis-causing parasite Leishmania donovani . The present invention concerns compositions useful for control of Leishmania spp. parasites in vitro and in vivo and treatment of leishmaniasis; methods for treatment of leishmaniasis; and methods for controlling Leishmania spp. parasites in vitro and in vivo.

  在筛选程序中，发现南极海绵Dendrilla membranosa产生二萜类次生代谢物，对引起利什曼病的寄生虫Leishmania donovani具有活性。本发明涉及用于控制离子球虫属寄生虫的组成物，包括体外和体内的治疗利什曼病的方法，以及控制离子球虫属寄生虫体内和体外的方法。
• Medical devices and applications of polyhydroxyalkanoate polymers
  申请人：METABOLIX, INC.

  公开号：EP2305324B1

  公开（公告）日：2014-09-17
• Preparation Of Nanoparticle Materials
  申请人：O'Brien Paul

  公开号：US20070202333A1

  公开（公告）日：2007-08-30

  A method of producing nanoparticles comprises effecting conversion of a nanoparticle precursor composition to the material of the nanoparticles. The precursor composition comprises a first precursor species containing a first ion to be incorporated into the growing nanoparticles and a separate second precursor species containing a second ion to be incorporated into the growing nanoparticles. The conversion is effected in the presence of a molecular cluster compound under conditions permitting seeding and growth of the nanoparticles.
• Carbonylative Polymerization Methods
  申请人：Coates Geoffrey W.

  公开号：US20130158230A1

  公开（公告）日：2013-06-20

  Provided are methods forming polymers. The methods include, for example, tandem carbonylation and polymerization reactions, where epoxides are catalytically carbonylated to form lactones and the lactones catalytically polymerized to form polymers without the need to isolate or purify the lactone intermediate. Also provided are methods for catalytically polymerizing beta-propiolactone. Homopolymers and copolymers can be formed using the methods disclosed herein.
• PRODUCTION OF POLYHYDROXYALKANOATES WITH A DEFINED COMPOSITION FROM AN UNRELATED CARBON SOURCE
  申请人：WISCONSIN ALUMNI RESEARCH FOUNDATION

  公开号：US20140073022A1

  公开（公告）日：2014-03-13

  Cells and methods for producing polyhydroxyalkanoates. The cells comprise one or more recombinant genes selected from an R-specific enoyl-CoA hydratase gene, a PHA polymerase gene, a thioesterase gene, and an acyl-CoA-synthetase gene. The cells further have one or more genes functionally deleted. The functionally deleted genes include such genes as an enoyl-CoA hydratase gene, a 3-hydroxyacyl-CoA dehydrogenase, and a 3-ketoacyl-CoA thiolase gene. The recombinant cells are capable of using producing polyhydroxyalkanoates with a high proportion of monomers having the same carbon length from non-lipid substrates, such as carbohydrates.