NIOSH REL: TWA 0.5 ppm (2.7 mg/m3), IDLH 500 ppm; OSHA PEL: TWA
100 ppm (540 mg/m3); ACGIH TLV: TWA 5 ppm (adopted).
LogP：
0.449 (est)
物理描述：
Ethylene glycol monoethyl ether acetate appears as a clear colorless liquid with a pleasant odor. Flash point of 120°F. Less dense than water. Vapors are heavier than air.
颜色/状态：
Colorless liquid
气味：
MILD ESTER-LIKE ODOR BECOMES OBJECTIONABLE IN HIGH CONCN ...
味道：
... A BITTER ACID TASTE
蒸汽密度：
4.72 (NTP, 1992) (Relative to Air)
蒸汽压力：
2.00 mm Hg at 25 °C
亨利常数：
3.20e-06 atm-m3/mole
大气OH速率常数：
1.30e-11 cm3/molecule*sec
自燃温度：
715 °F (379 °C)
分解：
WHEN HEATED TO DECOMPOSITION IT EMITS ACRID SMOKE AND IRRITATING FUMES.
The urinary excretion of ethoxyacetic acid was studied in male volunteers exposed to ethylene glycol monoethyl ether acetate, of which ethoxyacetic-acid is a metabolite. Five of the volunteers, aged 21 to 30 years, were exposed to 14, 28, and 50 mg/cu m at rest, and five were exposed to 28 mg/cu m at rest and during exercise at 30 and 60 watts. Individuals were exposed to each concentration for periods of 4 hours. Unexposed periods between the experiments lasted 2 to 3 weeks. Maximal ethoxyacetic acid excretion took place 3 to 4 hours after exposure was discontinued; the half life for elimination was 23.6 hours. It was found that after physical exercise, a second maximum of excretion was observed approximately 3 hours after the first one. Approximately 22% of the absorbed ethylene glycol monoethyl ether acetate dose was recovered in the urine as ethoxyacetic acid after 42 hours.
The urinary excretion of ethoxyacetic acid was studied in a group of five women daily exposed to the ethyl ether of ethylene glycol and the ethyl ether of ethylene glycol acetate during 5 days of normal production and 7 days after a 12 days production stop. The mean combined exposure concentration of ethyl ether of ethylene glycol and ethylene glycol ethyl ether acetate (expressed in equivalent weight of ethyl ether of ethylene glycol was 14.0 mg/cu m with occasional slight excursions above the current Belgian occupational exposure limit. The daily combined exposures profiles for ethylene glycol ethyl ether and ethylene glycol ethyl ether acetate were rather constant during the first observation period, but they tended to decrease during the last week. The urinary ethoxyacetic acid excretion clearly increased during the work week. Over the weekends the elimination was far from complete, and even after a prolonged nonexposure period of 12 days traces of the metabolite were still detectable. Based on the observations from the first period, a good linear correlation was found between the average exposure over 5 days (914.4 mg/cu m) and the ethoxyacetic acid excretion of the end of the week (105.7 mg/g creatinine). An ethoxyacetic acid estimate of 150 + or - 35 mg/g was found to correspond with repeated 5 days full-shift exposures to the respective occupational exposure limit of ethylene glyol ethyl ether (19 mg/cu m) or ethylene glycol ethyl ether acetate (27 mg/cu m).
Seventeen persons who were exposed to glycol ethers in a varnish production plant, were examined according to their external and internal solvent exposure. The workers in the production plant (n= 12) were exposed to average concentrations of ethoxyethanol, ethoxyethyl acetate, butoxyethanol, 1-methoxypropanol-2, 2-methoxypropyl-1-acetate and xylene of 2.8; 2.7; 1.1; 7.0; 2.8 and 1.7 ppm. Internal exposure was estimated by measuring butoxyethanol in blood as well as ethoxyacetic acid and butoxyacetic acid in urine samples. As expected, the highest values were found in the varnish production. The average post shift concentrations of butoxyethanol, ethoxyacetic acid and butoxyacetic acid were 121.3 ug/L; 167.8 and 10.5 mg/L. The relatively high concentrations of ethoxyacetic acid and butoxyacetic acid in pre-shift samples can be explained by the long half-lives of these metabolites. Most of the glycol ethers were taken up through the skin. The authors think that a future tolerable limit value for the concentration of ethoxyacetic acid in urine should be in the order of 100 to 200 mg/L.
... The methyl and ethyl ethers of ethylene glycol, ie 2- methoxyethanol (2-ME) esters, 2-methoxyethyl acetate (2-MEA) and 2-ethoxyethyl acetate (2- EEA) ... are all stable, and are all miscible with (or in the case of 2-EEA very soluble in) water and miscible with a large number of organic solvents. ... The solubility of these glycol ethers in water and their relatively low vapor pressure could result in their build-up in water in the absence of degradation. However, degradation by microorganisms in soil, sewage sludge, and water appears to prevent this possibility. Atmospheric emissions resulting from the use of glycol ethers as evaporative solvents result in the greatest environmental exposure.... Effects on Organisms in the Environment: The toxicity of 2-ME and 2-EE to microorganisms and aquatic animals appears to be low. ... The glycol ether acetates (2-MEA and 2-EEA) are far more toxic to fish. The LC50 of 2-EEA for fathead minnows is 46 mg/L and that of 2-MEA for tidewater silverfish and bluegills is 45 mg/L. ... Effects on Experimental Animals and In Vitro Test Systems: Systemic toxicity: The toxicity of 2-ME and 2-EE to experimental animals has been much more widely studied than that of 2-MEA and 2-EEA. 2-ME and 2-EE and their acetates have similar lethalities after single exposures and they show low acute lethality whether exposure is via the dermal, oral, or inhalation route. Oral LD60 values for a variety of species range between 900 and 3400 mg/kg body weight for 2-ME, 1400 and 5500 mg/kg for 2-EE, 1250 and 3930 mg/kg for 2-MEA, and 1300 and 5100 mg/kg for 2-EEA. ... 2-EE was found to be teratogenic (in the presence of slight maternal toxicity). Another study reported fetotoxicity but no malformations in rats exposed to 184 or 920 mg 2-EE/cu m, and in rabbits exposed to 644 mg 2-EE/cu m. NOEL values for developmental effects were 37 mg/cu m for rats and 184 mg/cu m for rabbits. Behavioral and neurochemical alterations were seen in the offspring of rats exposed to 368 mg 2-EE/cu m on days 7-13 or 14-20 of gestation. Rats treated by dermal application of 0.25 mL undiluted 2-EE (four times daily on gestation days 7-16) exhibited marked fetotoxicity and a high incidence of malformation in the absence of maternal toxicity. Similar effects were noted following 2-EEA treatment of rats, using the same protocol, at an equimolar dose (0.35 mL, four times daily). Inhalation exposure of rabbits to 2-EEA on gestation days 6-18 produced teratogenic responses at 2176 mg/cu m and 544 mg/cu m in two different studies, the developmental NOEL values in these two studies being 135 mg/m3 and 270 mg/m3. Exposure of rats to 2-EEA on days 6-15 of gestation produced fetotoxicity at 540 mg/cu m and malformation at 1080 mg/cu m. The developmental NOEL was 170 mg/cu m. Effects on humans: Information on the toxic effects of these four glycol ethers on humans is limited. The results from the few case reports and workplace epidemiological studies are consistent with the adverse effects seen in experimental animals. No reports quantifying general population exposure and health effects have been found. ...
来源:Hazardous Substances Data Bank (HSDB)
毒理性
暴露途径
该物质可以通过吸入其蒸汽、通过皮肤接触以及摄入进入人体。
The substance can be absorbed into the body by inhalation of its vapour, through the skin and by ingestion.
来源:ILO-WHO International Chemical Safety Cards (ICSCs)
Pulmonary absorption and elimination of ethylene glycol monoethyl ether acetate were studied in humans. Male volunteers were exposed at rest or while exercising. Exposure periods were 4 hr with a 10 min break between each hour of exposure. ... Retention, atmospheric clearance, and rate of uptake of ethylene glycol monoethyl ether acetate decreased as exposure proceeded. Steady state values of these parameters were attained after 3 to 4 hr. The relative amounts of ethylene glycol monoethyl ether acetate in the expired air decreased as uptake increased. Individual uptake of ethylene glycol monoethyl ether acetate was mainly governed by pulmonary ventilation rate, cardiac output and anthropometric factors such as percent body fat. Retention increased with increasing ethylene glycol monoethyl ether acetate exposure concentration and increasing workload during exercise. The rate of uptake also increased with workload during exercise. This was attributed primarily to an increased pulmonary ventilation rate. Ethylene glycol monoethyl ether as well as ethylene glycol monoethyl ether acetate was detected in the expired air. Respiratory elimination of ethylene glycol monoethyl ether after exposure ended was biphasic. Respiratory elimination of ethylene glycol monoethyl ether acetate, however, was a minor route of excretion, only around 0.5% uptake being recovered in the expired air. Respiratory elimination of ethylene glycol monoethyl ether acetate was significantly correlated only with total body uptake, body fat content, and pulmonary ventilation rate.
The absorption and elimination rates of 2-propoxyethyl acetate and 2-ethoxyethyl acetate were compared following inhalation, dermal application, and intravenous administration in male beagle-dogs. Exposure to 50 ppm 2-propoxyethyl acetate and 2-ethoxyethyl acetate resulted in rapid absorption through the lungs. Breath concentrations of 2-propoxyethyl acetate and 2-ethoxyethyl acetate showed a rapid increase with the duration of the exposure and reached a plateau after 3 hours. After iv administration of 1 mg/kg radiolabeled 2-propoxyethyl acetate, dogs eliminated about 88% of the radioactivity in the urine within 24 hours; about 61% of an equivalent dose of 2-ethoxyethyl acetate was excreted in the urine within 24 hours. Blood radioactivity after 2-propoxyethyl acetate administration was cleared more rapidly than after 2-ethoxyethyl acetate. For each compound, the amounts absorbed were similar after 30 and 60 minute exposures. The in vitro percutaneous absorption lag times were 1.2 and 1.6 hours for 2-propoxyethyl acetate and 2-ethoxyethyl acetate, respectively. Neither 2-ethoxyethyl acetate nor 2-propoxyethyl acetate altered the diffusion properties of the skin preparations. Although the excretion rates for 2-propoxyethyl acetate and 2-ethoxyethyl acetate are markedly different, the total amount of each compound absorbed through the skin and lungs is similar.
BIS(ARYLMETHYLIDENE)ACETONE COMPOUND, ANTI-CANCER AGENT, CARCINOGENESIS-PREVENTIVE AGENT, INHIBITOR OF EXPRESSION OF Ki-Ras, ErbB2, c-Myc AND CYCLINE D1, BETA-CATENIN-DEGRADING AGENT, AND p53 EXPRESSION ENHANCER
申请人：Shibata Hiroyuki
公开号：US20100152493A1
公开（公告）日：2010-06-17
It has been demanded to improve the poor solubility of curcumin to develop an anti-tumor compound capable of inhibiting the growth of various cancer cells at a low concentration. Thus, disclosed is a novel synthetic compound, a bis(arylmethylidene)acetone, which has both of an excellent anti-tumor activity and a chemo-preventive activity. A bis(arylmethylidene)acetone (i.e., a derivative having a curcumin skeleton) which is an anti-tumor compound and has a chemo-preventive activity is synthesized and screened. A derivative having enhanced anti-tumor activity and chemo-preventive activity can be synthesized.
[EN] OXIME ESTER PHOTOINITIATORS<br/>[FR] PHOTO-INITIATEURS À BASE D'ESTER D'OXIME
申请人：BASF SE
公开号：WO2021175855A1
公开（公告）日：2021-09-10
Disclosed are α-oxo oxime ester compounds based on carbazole derivatives which have specific substituent groups useful as a photoinitiator, as well as photopolymerizable compositions comprising said photoinitiator and ethylenically unsaturated compounds. The photopolymerizable compositions are useful, for example, in photoresist formulations for display applications, e.g. liquid crystal display (LCD), organic light emitting diode (OLED) and touch panel.
Method of Fabricating Glycol Monoalkyl Ether Acetate Using Acidic Ionic Liquid Catalyst
申请人：Wu Jung-Chung
公开号：US20110184207A1
公开（公告）日：2011-07-28
A new method for fabricating glycol monoalkyl ether acetate (GMAEA) is provided. A Bronsted acidic ionic liquid is used. After some reactions, two layers of materials are formed. A product of GMAEA is obtained at the upper layer. The lower layer is the ionic liquid. Thus, the ionic liquid is reusable for re-fabricating the product. And, furthermore, waste acid is reduced.
AROMATIC AMINE COMPOUND, CURING AGENT FOR EPOXY COMPOUND, CURABLE COMPOSITION, CURED PRODUCT, METHOD FOR PRODUCING CURED PRODUCT, AND METHOD FOR PRODUCING AROMATIC AMINE COMPOUND
申请人：TOKYO OHKA KOGYO CO., LTD.
公开号：US20210130284A1
公开（公告）日：2021-05-06
An aromatic amine compound capable of satisfactorily forming a cured product having exceptional alkali resistance by reaction with an epoxy compound; a curing agent for an epoxy compound, the curing agent including the aromatic amine compound; a curable composition including the curing agent for an epoxy compound; a cured product of the curable composition; a method for producing the cured product; and a method for producing the abovementioned aromatic amine compound. The aromatic amine compound has a structure such that a specific position in a central skeleton comprising a fused ring such as a fluorene ring is substituted with a side-chain group including two aromatic groups linked by a flexible bond such as an amide bond, at least one amino group is bonded to the end of the side-chain group, and the structure has no hydroxyl groups.
