乙基二氯化磷 | 1498-40-4

• 物质功能分类: 有机原料 - 有机膦化合物
• 分子结构分类: 有机化合物 - 有机磷化合物 - 烷基卤代膦
• 中文名称: 乙基二氯化磷
• 中文别名: 二氯化乙膦；乙基二氯化膦
• 英文名称: dichlorophosphinoethane
• 英文别名: ethyldichlorophosphine；ethylphosphine dichloride；dichloro(ethyl)phosphane
• CAS: 1498-40-4
• 化学式: C₂H₅Cl₂P
• mdl: MFCD00013617
• 分子量: 130.941
• InChiKey: JHNJGLVSPIMBLD-UHFFFAOYSA-N

物化性质

• 沸点：
  112 °C(lit.)
• 密度：
  1.26 g/mL at 25 °C(lit.)
• 闪点：
  91 °F
• 物理描述：
  Ethyl phosphonous dichloride, anhydrous appears as a colorless liquid with a pungent odor. Denser than water. Very toxic by inhalation.
• 稳定性/保质期：
  不稳定，对空气和水分敏感。应避免与不相容材料、火源、空气、水或湿空气接触。它会与强氧化剂和强碱发生反应。

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  5
• 可旋转键数：
  0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

ADMET

毒理性

• 副作用

Dermatotoxin - 皮肤烧伤。

Dermatotoxin - Skin burns.

来源:Haz-Map, Information on Hazardous Chemicals and Occupational Diseases

毒理性

• 毒性数据

LCLo（小鼠）= 1,990 毫克/立方米/10分钟

LCLo (mice) = 1,990 mg/m3/10 min

来源:Haz-Map, Information on Hazardous Chemicals and Occupational Diseases

安全信息

• 危险等级：
  4.2
• 危险品标志：
  F,C
• 安全说明：
  S26,S36/37/39,S43,S45,S6
• 危险类别码：
  R14
• WGK Germany：
  3
• 海关编码：
  2903199000
• RTECS号：
  TB2465000
• 包装等级：
  I
• 危险类别：
  4.2
• 危险品运输编号：
  UN 2845 4.2/PG 1
• 储存条件：
  密封储存，应存放于阴凉、干燥的库房中，并远离火源和易燃易爆区域以及水分。通常建议使用氮气进行保护。

SDS

Name:	Ethyl Dichlorophosphine Material Safety Data Sheet
Synonym:	Dichlor-Ethylfosfin; Dichloroethylphosphine
CAS:	1498-40-4

Section 1 - Chemical Product MSDS Name:Ethyl Dichlorophosphine Material Safety Data Sheet
Synonym:Dichlor-Ethylfosfin; Dichloroethylphosphine

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Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS

CAS#	Chemical Name	content	EINECS#
1498-40-4	Ethyl Dichlorophosphine	ca 100	216-096-4

Hazard Symbols: C
Risk Phrases: 10 14 34

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Section 3 - HAZARDS IDENTIFICATION
EMERGENCY OVERVIEW
Flammable. Reacts violently with water. Causes burns.Corrosive.Lachrymator (substance which increases the flow of tears).Water-reactive.
Potential Health Effects
Eye:
Causes eye burns. Lachrymator (substance which increases the flow of tears). When substance becomes wet or comes in contact with moisture of the mucous membranes, it will cause irritation. May cause chemical conjunctivitis and corneal damage.
Skin:
Causes skin burns. Contact with skin causes irritation and possible burns, especially if the skin is wet or moist. May cause cyanosis of the extremities. May cause skin rash (in milder cases), and cold and clammy skin with cyanosis or pale color.
Ingestion:
May cause severe and permanent damage to the digestive tract. Causes gastrointestinal tract burns. May cause perforation of the digestive tract. Ingestion of large amounts may cause CNS depression. May cause systemic effects.
Inhalation:
Causes chemical burns to the respiratory tract. Aspiration may lead to pulmonary edema. Vapors may cause dizziness or suffocation. May cause systemic effects. May cause burning sensation in the chest.
Chronic:
Effects may be delayed.

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Section 4 - FIRST AID MEASURES
Eyes: Get medical aid immediately. Do NOT allow victim to rub eyes or keep eyes closed. Extensive irrigation with water is required (at least 30 minutes).
Skin:
Get medical aid immediately. Immediately flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse. Destroy contaminated shoes.
If water-reactive products are embedded in the skin, no water should be applied. The embedded products should be covered with a light oil.
Ingestion:
Do not induce vomiting. If victim is conscious and alert, give 2-4 cupfuls of milk or water. Get medical aid immediately.
Inhalation:
Get medical aid immediately. Remove from exposure and move to fresh air immediately. If breathing is difficult, give oxygen. Do NOT use mouth-to-mouth resuscitation. If breathing has ceased apply artificial respiration using oxygen and a suitable mechanical device such as a bag and a mask.
Notes to Physician:

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Section 5 - FIRE FIGHTING MEASURES
General Information:
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. Vapors may form an explosive mixture with air.
Vapors can travel to a source of ignition and flash back. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Will burn if involved in a fire. Water Reactive. Material will react with water and may release a flammable and/or toxic gas. Use water spray to keep fire-exposed containers cool. Containers may explode in the heat of a fire. Flammable liquid and vapor. Vapors may be heavier than air. They can spread along the ground and collect in low or confined areas. May ignite or explode on contact with steam or moist air.
Extinguishing Media:
Use dry sand or earth to smother fire. Use water spray to cool fire-exposed containers. If water is the only media available, use in flooding amounts. DO NOT USE WATER! Do NOT get water inside containers. Contact professional fire-fighters immediately.

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Section 6 - ACCIDENTAL RELEASE MEASURES
General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Absorb spill with inert material (e.g. vermiculite, sand or earth), then place in suitable container. Avoid runoff into storm sewers and ditches which lead to waterways. Clean up spills immediately, observing precautions in the Protective Equipment section. Remove all sources of ignition. Use a spark-proof tool. Provide ventilation. Do not expose spill to water. Do not get water inside containers. A vapor suppressing foam may be used to reduce vapors.

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Section 7 - HANDLING and STORAGE
Handling:
Use only in a well-ventilated area. Do not allow water to get into the container because of violent reaction. Ground and bond containers when transferring material. Use spark-proof tools and explosion proof equipment. Avoid contact with eyes, skin, and clothing. Empty containers retain product residue, (liquid and/or vapor), and can be dangerous. Keep away from heat, sparks and flame. Avoid ingestion and inhalation. Do not allow contact with water. Discard contaminated shoes. Do not pressurize, cut, weld, braze, solder, drill, grind, or expose empty containers to heat, sparks or open flames. Keep from contact with moist air and steam.
Storage:
Keep away from heat, sparks, and flame. Keep away from sources of ignition. Keep container closed when not in use. Keep away from water. Flammables-area. Store protected from moisture.

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Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
Engineering Controls:
Use explosion-proof ventilation equipment. Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate ventilation to keep airborne concentrations low.
Exposure Limits CAS# 1498-40-4: Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to minimize contact with skin.
Respirators:
Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced.

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Section 9 - PHYSICAL AND CHEMICAL PROPERTIES

Physical State: Liquid
Color: colorless
Odor: Not available.
pH: Not available.
Vapor Pressure: Not available.
Viscosity: Not available.
Boiling Point: 112 deg C
Freezing/Melting Point: Not available.
Autoignition Temperature: Not available.
Flash Point: 32 deg C ( 89.60 deg F)
Explosion Limits, lower: Not available.
Explosion Limits, upper: Not available.
Decomposition Temperature:
Solubility in water: Reacts.
Specific Gravity/Density: 1.2600g/cm3
Molecular Formula: C2H5PCl2
Molecular Weight: 130.94

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Section 10 - STABILITY AND REACTIVITY
Chemical Stability:
Combines vigorously or explosively with water.
Conditions to Avoid:
Incompatible materials, ignition sources, moisture, excess heat, exposure to moist air or water.
Incompatibilities with Other Materials:
Moisture, strong oxidizing agents.
Hazardous Decomposition Products:
Carbon monoxide, irritating and toxic fumes and gases, carbon dioxide, hydrogen fluoride gas, hydrogen bromide.
Hazardous Polymerization: Has not been reported

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Section 11 - TOXICOLOGICAL INFORMATION
RTECS#:
CAS# 1498-40-4: TB2465000 LD50/LC50:
Not available.
Carcinogenicity:
Ethyl Dichlorophosphine - Not listed by ACGIH, IARC, or NTP.
Other:
See actual entry in RTECS for complete information.

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Section 12 - ECOLOGICAL INFORMATION

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Section 13 - DISPOSAL CONSIDERATIONS
Dispose of in a manner consistent with federal, state, and local regulations.

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Section 14 - TRANSPORT INFORMATION

IATA
Shipping Name: CORROSIVE LIQUID, FLAMMABLE, N.O.S.*
Hazard Class: 8 (3)
UN Number: 2920
Packing Group: II
IMO
Shipping Name: CORROSIVE LIQUID, FLAMMABLE, N.O.S.
Hazard Class: 8 (3)
UN Number: 2920
Packing Group: II
RID/ADR
Shipping Name: CORROSIVE LIQUID, FLAMMABLE, N.O.S.
Hazard Class: 8 (3)
UN Number: 2920
Packing group: II

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Section 15 - REGULATORY INFORMATION

European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: C
Risk Phrases:
R 10 Flammable.
R 14 Reacts violently with water.
R 34 Causes burns.
Safety Phrases:
S 8 Keep container dry.
S 9 Keep container in a well-ventilated place.
S 16 Keep away from sources of ignition - No
smoking.
S 25 Avoid contact with eyes.
S 33 Take precautionary measures against static
discharges.
S 36/37/39 Wear suitable protective clothing, gloves
and eye/face protection.
S 45 In case of accident or if you feel unwell, seek
medical advice immediately (show the label where
possible).
WGK (Water Danger/Protection)
CAS# 1498-40-4: No information available.
Canada
None of the chemicals in this product are listed on the DSL/NDSL list.
CAS# 1498-40-4 is listed on Canada's Ingredient Disclosure List.
US FEDERAL
TSCA
CAS# 1498-40-4 is not listed on the TSCA inventory.
It is for research and development use only.

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SECTION 16 - ADDITIONAL INFORMATION
N/A

反应信息

• 作为反应物：
  描述：

  乙基二氯化磷 在 水 、 硝酸 作用下， 生成 乙基磷酸
  参考文献：
  名称：

  Michaelis, Chemische Berichte, 1880, vol. 13, p. 2174

  摘要：

  DOI：
• 作为产物：
  描述：

  四乙基铅 在 三氯化磷 作用下， 生成 乙基二氯化磷
  参考文献：
  名称：

  Kharasch; Jensen; Weinhouse, Journal of Organic Chemistry, 1949, vol. 14, p. 432

  摘要：

  DOI：
• 作为试剂：
  描述：

  甲基丙烯酰胺 在 乙基二氯化磷 作用下， 以 苯 为溶剂， 生成 2-氯-2-甲基丙腈
  参考文献：
  名称：

  Khairullin,V.K.; Pudovik,A.N., Journal of general chemistry of the USSR, 1967, vol. 37, # 12, p. 2610 - 2613

  摘要：

  DOI：

文献信息

• Uses of metallacyclobutenes in heterocyclic synthesis. Synthesis and structural characterization of 1,2-dihydrophosphetes
  作者：Kenneth M. Doxsee、Gregory S. Shen、Carolyn B. Knobler

  DOI：10.1021/ja00207a035

  日期：1989.12

  Synthese de dihydro-1,2 triphenyl-1,3,4 (ou alkyl-1 diphenyl-3,4) phosphete a partir de di-[η 5 -cyclopentadienyl]-1,1 diphenyl-2,3 zirconacyclo butene-2 et de phenyl (ou alkyl) dichloro phosphine

  合成这些 de dihydro-1,2 triphenyl-1,3,4 (oualkyl-1 diphenyl-3,4) phosphete a partir de di-[η 5 -cyclopentadienyl]-1,1 diphenyl-2,3 zirconacyclobutene-2 et de 苯基 (ou 烷基) 二氯膦
• Asymmetric Hydrogenation of Ketones Using a Ruthenium(II) Catalyst Containing BINOL-Derived Monodonor Phosphorus-Donor Ligands
  作者：Yingjian Xu、Nat W. Alcock、Guy J. Clarkson、Gordon Docherty、Gary Woodward、Martin Wills

  DOI：10.1021/ol0481840

  日期：2004.10.1

  [structure: see text] A series of ruthenium(II) complexes containing BINOL-based monodonor phosphorus ligands have been prepared and applied to the asymmetric catalysis of the hydrogenation of aryl/alkyl ketones. The best ligands for this application are those which contain an aromatic groups with either a methoxide or bromide on the ortho position. Using these ligands, alcohols with ee's of up to

  [结构：见正文]制备了一系列含BINOL基单供体磷配体的钌（II）配合物，并将其用于芳基/烷基酮氢化的不对称催化。对于该应用而言，最好的配体是那些含有在邻位带有甲氧基或溴化物的芳族基团的配体。使用这些配体，可以形成ee高达99％的醇。
• Further studies in the chemistry of 2,3-dihydro-1,2,3-triphenyl-1H-1,2,3-benzotriphosphole and related compounds. Part II
  作者：Frederick G. Mann、Anthony J. H. Mercer

  DOI：10.1039/p19720002548

  日期：——

  o-Phenylenebis(phenylphosphine)(II), now readily available, is a valuable precursor in the synthesis of several new heterocyclic systems having a benzene ring fused to a five- or six-membered ring containing at least two phosphorus atoms. The following heterocyclic systems (with phenyl substituents) have been prepared: the 1,2,3-benzotriphospholes (V; R = Me or Et); the 1,3,2-benzodiphospharsoles (VIII;

  现已很容易获得的邻苯二甲双（苯基膦）（II）是几种新的杂环体系的合成中有价值的前体，这些杂环体系的苯环与含至少两个磷原子的五元或六元环稠合。已经制备了下列杂环系统（具有苯基取代基）：1,2,3-苯并三磷（V； R = Me或Et）；1,3,2-苯并二磷基（VIII; R = Ph或Me）; 1,3-苯并二磷（X）; 1,4-苯并二膦酸酯（XI）和（XXVII）; 和二苯并[ c，g ] [1,2,5,6]-四磷霉素（XXIII）。已经研究了这些化合物的化学和光谱性质。
• Phosphine-Imidazolyl Ligands for the Efficient Ruthenium-Catalyzed Hydrogenation of Carboxylic Esters
  作者：Kathrin Junge、Bianca Wendt、Felix Alexander Westerhaus、Anke Spannenberg、Haijun Jiao、Matthias Beller

  DOI：10.1002/chem.201200408

  日期：2012.7.16

  The synthesis of phosphine–imidazolyl ligands 1 and 2 in good yields is presented. In combination with [Ru(benzene)Cl2}2], ligands 1 c and 1 e formed efficient catalyst systems for the selective hydrogenation of various carboxylic esters into their corresponding primary alcohols. Furthermore, the structures of four ruthenium complexes with ligands 1 b, 1 c, 1 d, and 1 e were determined by X‐ray crystallography

  提出了高产率的膦-咪唑基配体1和2的合成。与[Ru（苯）Cl 2 } 2 ]结合，配体1c和1e形成有效的催化剂体系，用于将各种羧酸酯选择性加氢成它们相应的伯醇。此外，通过X射线晶体学测定了具有配体1b，1c，1d和1e的四种钌配合物的结构，其显示出根据配体结构的不同配位模式的形成。
• 1,2-hydroxy phosphonates and derivatives thereof
  申请人：E. R. Squibb & Sons, Inc.

  公开号：US05217958A1

  公开（公告）日：1993-06-08

  Compounds of the formula ##STR1## are disclosed. These compounds are inhibitors of renin and therefore useful as cardiovascular agents.

  公开了式##STR1##的化合物。这些化合物是肾素抑制剂，因此可用作心血管药物。

表征谱图