1-((4-isopropylbenzyl)oxy)-1,1,3,3-tetramethyldisiloxane

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: 1-((4-isopropylbenzyl)oxy)-1,1,3,3-tetramethyldisiloxane
• 英文别名: Dimethylsilyloxy-dimethyl-[(4-propan-2-ylphenyl)methoxy]silane；dimethylsilyloxy-dimethyl-[(4-propan-2-ylphenyl)methoxy]silane
• 化学式: C₁₄H₂₆O₂Si₂
• 分子量: 282.53
• InChiKey: GJJMODNWUHWRHZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.03
• 重原子数：
  18
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  18.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1-((4-isopropylbenzyl)oxy)-1,1,3,3-tetramethyldisiloxane 在 溶剂黄146 作用下， 以 甲醇 为溶剂， 以100%的产率得到4-异丙基苯甲醇
  参考文献：
  名称：

  Efficient hydrosilylation of carbonyl compounds by 1,1,3,3-tetramethyldisiloxane catalyzed by Au/TiO2

  摘要：

  1,1,3,3-Tetramethyldisiloxane (TMDS) is a highly reactive reducing reagent in the Au/TiO2-catalyzed hydrosilylation of carbonyl compounds relative to monohydrosilanes. The reduction of aldehydes or ketones with TMDS can be performed on many occasions at ambient conditions within short reaction times and at low loading levels of gold, whereas typical monohydrosilanes require excess heating and prolonged time for completion. The product yields are excellent, while almost stoichiometric amounts of carbonyl compounds and TMDS can be used. It is postulated that the enhanced reactivity of TMDS is attributed to the formation of a gold dihydride intermediate. This intermediate is also supported by the fact that double hydrosilylation of carbonyl compounds by TMDS is a negligible pathway. (C) 2014 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2014.03.094
• 作为产物：
  描述：

  1,1,3,3-四甲基二硅氧烷 、 4-异丙基苯甲醛 以 四氢呋喃 为溶剂， 反应 0.67h， 以88%的产率得到1-((4-isopropylbenzyl)oxy)-1,1,3,3-tetramethyldisiloxane
  参考文献：
  名称：

  Efficient hydrosilylation of carbonyl compounds by 1,1,3,3-tetramethyldisiloxane catalyzed by Au/TiO2

  摘要：

  1,1,3,3-Tetramethyldisiloxane (TMDS) is a highly reactive reducing reagent in the Au/TiO2-catalyzed hydrosilylation of carbonyl compounds relative to monohydrosilanes. The reduction of aldehydes or ketones with TMDS can be performed on many occasions at ambient conditions within short reaction times and at low loading levels of gold, whereas typical monohydrosilanes require excess heating and prolonged time for completion. The product yields are excellent, while almost stoichiometric amounts of carbonyl compounds and TMDS can be used. It is postulated that the enhanced reactivity of TMDS is attributed to the formation of a gold dihydride intermediate. This intermediate is also supported by the fact that double hydrosilylation of carbonyl compounds by TMDS is a negligible pathway. (C) 2014 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2014.03.094

文献信息

• Efficient hydrosilylation of carbonyl compounds by 1,1,3,3-tetramethyldisiloxane catalyzed by Au/TiO2
  作者：Eleni Vasilikogiannaki、Ioannis Titilas、Charis Gryparis、Anastasia Louka、Ioannis N. Lykakis、Manolis Stratakis

  DOI：10.1016/j.tet.2014.03.094

  日期：2014.9

  1,1,3,3-Tetramethyldisiloxane (TMDS) is a highly reactive reducing reagent in the Au/TiO2-catalyzed hydrosilylation of carbonyl compounds relative to monohydrosilanes. The reduction of aldehydes or ketones with TMDS can be performed on many occasions at ambient conditions within short reaction times and at low loading levels of gold, whereas typical monohydrosilanes require excess heating and prolonged time for completion. The product yields are excellent, while almost stoichiometric amounts of carbonyl compounds and TMDS can be used. It is postulated that the enhanced reactivity of TMDS is attributed to the formation of a gold dihydride intermediate. This intermediate is also supported by the fact that double hydrosilylation of carbonyl compounds by TMDS is a negligible pathway. (C) 2014 Elsevier Ltd. All rights reserved.