N-(4-hydroxyphenyl)retinamide

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: N-(4-hydroxyphenyl)retinamide
• 英文别名: (2E,4E,6E,8E)-3,7-dimethyl-N-(4-methylphenyl)-9-(2,6,6-trimethylcyclohexen-1-yl)nona-2,4,6,8-tetraenamide
• 化学式: C₂₇H₃₅NO
• 分子量: 389.581
• InChiKey: VTTINSVGAVGJSN-CULLNNCPSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8
• 重原子数：
  29
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.37
• 拓扑面积：
  29.1
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  维A酸 在 吡啶 、 六氯丙酮 、 triphenylphosphine-resin 作用下， 以 四氢呋喃 为溶剂， 反应 1.0h， 生成 N-(4-hydroxyphenyl)retinamide
  参考文献：
  名称：

  Solid phase-assisted synthesis and screening of a small library of N-(4-hydroxyphenyl)retinamide (4-HPR) analogs

  摘要：

  Using solid phase-assisted synthesis and purification, a 49 member library of analogs of the main mammary tumor chemopreventive retinoid N-(4-hydroxyphenyl)retinamide (4-HPR) has been prepared. After prescreening for growth inhibitory activity in human mammary tumor cells (MCF-7) in culture, most of those analogs which showed activity (12 of them) were assayed for apoptosis-inducing activity in the MCF-7 cells. At least 3 of the analogs (13, 24, and 28) showed activity approaching that of 4-HPR. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2006.10.050

文献信息

• COMPOUNDS FOR IMPROVING LEARNING AND MEMORY
  申请人：Stephan A. Dietrich

  公开号：US20080108568A1

  公开（公告）日：2008-05-08

  The present invention provides a method for improving learning and memory in a subject by administering a therapeutically effective amount of a compound of Formula I: or of Formula II: or of Formula III: (R 1 ) x -Ser-Ile-Tyr-Arg-Arg-Gly-Ala-Arg-Arg-Trp-Arg-Lys-Leu —(R 2 ) y (III).
• METHODS FOR P2RY5 MEDIATED REGULATION OF HAIR GROWTH AND MUTANTS THEREOF
  申请人：Christiano Angela M.

  公开号：US20110189199A1

  公开（公告）日：2011-08-04

  The invention provides for a method for screening compounds that bind to and modulate the hair-specific G-protein coupled receptor, P2RY5. The invention further provides for methods for controlling hair growth by administering a P2RY5 modulating compound to a subject.
• Methods for P2RY5 Mediated Regulation of Hair Growth and Mutants Thereof
  申请人：The Trustees of Columbia University in the City of New York

  公开号：US20140134188A1

  公开（公告）日：2014-05-15

  The invention provides for a method for screening compounds that bind to and modulate the hair-specific G-protein coupled receptor, P2RY5. The invention farther provides for methods for controlling hair growth by administering a P2RY5 modulating compound to a subject.
• METHODS TO DECREASE SUSCEPTIBILITY TO ASTHMATIC BRONCHOCONSTRICTION
  申请人：Cornell University

  公开号：US20150139915A1

  公开（公告）日：2015-05-21

  Methods and compositions are described for reducing airway reactivity and the susceptibility to asthmatic bronchoconstriction that involve increasing sphingolipid content in airways and lungs of a mammalian subject.
• US7166744B2
  申请人：——

  公开号：US7166744B2

  公开（公告）日：2007-01-23