3-(4-hydroxyphenyl)-3,4-dihydro-2H-chromene-4,7,8-triol

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 异黄酮类化合物
• 英文名称: 3-(4-hydroxyphenyl)-3,4-dihydro-2H-chromene-4,7,8-triol
• 化学式: C₁₅H₁₄O₅
• 分子量: 274.27
• InChiKey: BNTLMCIMLNLCPE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  20
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  90.2
• 氢给体数：
  4
• 氢受体数：
  5

文献信息

• Production of isoflavone derivatives
  申请人：Heaton Andrew

  公开号：US20050143588A1

  公开（公告）日：2005-06-30

  Methods for the hydrogenation of isoflavones are described which provide access to workable quantities of isoflavan-4-ols, isoflav-3-enes, and isoflavans. The isoflavone derivatives can be obtained in high purity and in near quantitative yields whilst employing pharmaceutically acceptable reagents and solvents.

  描述了异黄酮氢化的方法，可以获得可操作数量的异黄烷-4-醇、异黄烯和异黄烷。在使用药用可接受的试剂和溶剂时，可以高纯度地获得异黄酮衍生物，并且产率接近定量。
• ANTI-INFLAMMATORY MODALITIES
  申请人：WALKER Catherine

  公开号：US20120059176A1

  公开（公告）日：2012-03-08

  Anti-inflammatory modalities are described with reference to select isoflavonoid compounds, compositions containing same and the use of said compounds and/or compositions in treatment, particularly for the treatment of inflammatory diseases and related conditions.

  本文描述了与选择的异黄酮化合物相关的抗炎疗法，包括含有这些化合物的组合物以及使用这些化合物和/或组合物进行治疗，特别是用于治疗炎症性疾病和相关症状。
• Anti-inflammatory Modalities
  申请人：Marshall Edwards, Inc.

  公开号：EP2526941A1

  公开（公告）日：2012-11-28

  Anti-inflammatory modalities are described with reference to select isoflavonoid compounds, compositions containing same and the use of said compounds and/or compositions in treatment, particularly for the treatment of inflammatory diseases and related conditions.

  抗炎模式的描述涉及精选的异黄酮化合物、含有异黄酮化合物的组合物以及所述化合物和/或组合物在治疗中的用途，特别是用于治疗炎症性疾病和相关病症。
• Combination chemotherapy compositions and methods
  申请人：Kelly Edmund Graham

  公开号：US20080069900A1

  公开（公告）日：2008-03-20

  This invention relates to combination therapies involving anticancer chemotherapeutic agents and isoflavones or analogues thereof. The invention flier relates to compounds, compositions, methods and therapeutic uses involving, containing, comprising, including and/or for preparing platinum-isoflavonoid complexes suitable for use in the combination therapies of the invention.
• PREVENTION AND REVERSAL OF CHEMOTHERAPY-INDUCED PERIPHERAL NEUROPATHY
  申请人：Brown David

  公开号：US20100152284A1

  公开（公告）日：2010-06-17

  Provided herein are methods for treating or preventing neuropathy, neuropathy-related conditions, wherein the neuropathy or neuropathy-related conditions are induced by, or otherwise associated with, treatment of the subject with at least one chemotherapeutic agent, the methods comprising administering an effective amount of an isoflavonoid compound of formula (I). Also provided are methods for the treatment of nerve damage. Also provided are uses of isoflavonoid compounds of formula (I) in the treatment of neuropathy, neuropathy-related conditions and nerve damage.