3-(4-hydroxyphenyl)-5-methyl-3,4-dihydro-2H-chromene-4,7-diol

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 异黄酮类化合物
• 英文名称: 3-(4-hydroxyphenyl)-5-methyl-3,4-dihydro-2H-chromene-4,7-diol
• 化学式: C₁₆H₁₆O₄
• 分子量: 272.29
• InChiKey: FDDOVKIYMKQDCQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  20
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  69.9
• 氢给体数：
  3
• 氢受体数：
  4

文献信息

• Combination chemotherapy compositions and methods
  申请人：Kelly Edmund Graham

  公开号：US20080069900A1

  公开（公告）日：2008-03-20

  This invention relates to combination therapies involving anticancer chemotherapeutic agents and isoflavones or analogues thereof. The invention flier relates to compounds, compositions, methods and therapeutic uses involving, containing, comprising, including and/or for preparing platinum-isoflavonoid complexes suitable for use in the combination therapies of the invention.
• PREVENTION AND REVERSAL OF CHEMOTHERAPY-INDUCED PERIPHERAL NEUROPATHY
  申请人：Brown David

  公开号：US20100152284A1

  公开（公告）日：2010-06-17

  Provided herein are methods for treating or preventing neuropathy, neuropathy-related conditions, wherein the neuropathy or neuropathy-related conditions are induced by, or otherwise associated with, treatment of the subject with at least one chemotherapeutic agent, the methods comprising administering an effective amount of an isoflavonoid compound of formula (I). Also provided are methods for the treatment of nerve damage. Also provided are uses of isoflavonoid compounds of formula (I) in the treatment of neuropathy, neuropathy-related conditions and nerve damage.
• US7906554B2
  申请人：——

  公开号：US7906554B2

  公开（公告）日：2011-03-15
• [EN] PREVENTION AND REVERSAL OF CHEMOTHERAPY-INDUCED PERIPHERAL NEUROPATHY<br/>[FR] PRÉVENTION ET INVERSION DE LA NEUROPATHIE PÉRIPHÉRIQUE INDUITE PAR UNE CHIMIOTHÉRAPIE
  申请人：NOVOGEN RES PTY LTD

  公开号：WO2008052256A1

  公开（公告）日：2008-05-08

  [EN] Provided herein are methods for treating or preventing neuropathy, neuropathy-related conditions, wherein the neuropathy or neuropathy-related conditions are induced by, or otherwise associated with, treatment of the subject with at least one chemotherapeutic agent, the methods comprising administering an effective amount of an isoflavonoid compound of formula (I). Also provided are methods for the treatment of nerve damage. Also provided are uses of isoflavonoid compounds of formula (I) in the treatment of neuropathy, neuropathy-related conditions and nerve damage.
  [FR] L'invention concerne des procédés visant à traiter ou prévenir la neuropathie et les états associés à la neuropathie, la neuropathie ou les états associés à la neuropathie étant induits par ou associés au traitement du sujet avec au moins un agent chimiothérapeutique, les procédés comprenant l'administration d'une quantité efficace d'un isoflavonoïde de formule (I). L'invention concerne également des procédés visant à traiter l'endommagement des nerfs, et l'utilisation d'isoflavonoïdes de formule (I) dans le traitement de la neuropathie, des états associés à la neuropathie et de l'endommagement des nerfs.