双环[2.2.1]庚烷-1-甲酰胺 | 69095-03-0

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 中文名称: 双环[2.2.1]庚烷-1-甲酰胺
• 英文名称: Norbornan-carbonsaeure-(1)-amid
• 英文别名: norbornane-1-carboxamide；Norbornan-1-carbamid；Bicyclo[2.2.1]heptane-1-carboxamide
• CAS: 69095-03-0
• 化学式: C₈H₁₃NO
• mdl: MFCD00497966
• 分子量: 139.197
• InChiKey: RPJTXFAFHGMXLE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  10
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.875
• 拓扑面积：
  43.1
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  双环[2.2.1]庚烷-1-甲酰胺 在 氢氧化钾 作用下， 生成 双环[2.2.1]庚烷-1-羧酸
  参考文献：
  名称：

  Stereochemistry of Diels-Alder Adducts. III. The Preparation and Rearrangement of Some Brominated Derivatives of Norbornanecarboxylic Acids

  摘要：

  DOI：

  10.1021/ja01520a038
• 作为产物：
  描述：

  1-Norbornancarbonylchlorid 在 ammonium hydroxide 作用下， 生成 双环[2.2.1]庚烷-1-甲酰胺
  参考文献：
  名称：

  Decomposition of Tertiary Alkyl Hypochlorites¹

  摘要：

  DOI：

  10.1021/jo01036a011

文献信息

• 2-Mercaptoacetamidines as gastric antisecretory agents
  作者：William A. Bolhofer、Charles N. Habecker、Adolph M. Pietruszkiewicz、Mary Lou Torchiana、Henry I. Jacoby、Clement A. Stone

  DOI：10.1021/jm00189a015

  日期：1979.3

  A series of N-substituted 2-mercaptoacetamidines was synthesized and evaluated for gastric antisecretory activity in dogs stimulated with gastrin tetrapeptide. The most potent analogues showed 80--95% inhibition of acid secretion after an oral dose of 8 mg/kg. Thus, these compounds represent a new structural type having significant antisecretory activity. Disulfides had essentially the same antisecretory

  合成了一系列的N-取代的2-巯基乙am，并评价了用胃泌素四肽刺激的狗的胃抗分泌活性。口服剂量为8 mg / kg后，最有效的类似物显示出80--95％的酸分泌抑制作用。因此，这些化合物代表具有显着抗分泌活性的新结构类型。二硫化物与相应的巯基乙acet具有基本相同的抗分泌能力，表明代谢相互转化。巯基的烷基化降低了效力。较高的羧am同系物，例如2-和3-巯基丙ion，具有非常低的活性。羟乙am和巯基乙酰胺的药效也很低。用这一系列化合物观察到的副作用包括呕吐，心动过速和胃出血。
• Triazine derivatives, processes for preparation thereof and pharmaceutical compositions comprising the same
  申请人：FUJISAWA PHARMACEUTICAL CO., LTD.

  公开号：EP0123254A1

  公开（公告）日：1984-10-31

  New triazine derivatives represented by the formula: wherein R' is hydrogen or halogen; R2 is a hydroxy, protected hydroxy, amino, cyano, mercapto, lower alkylthio, arylthio, sulfamoyl, lower alkylsulfonylamino, lower alkylureido, arylureido, lower alkyl-thioureido, aryl-thioureido, lower alkenoylamino, lower alkoxycarbonylamino, lower alkoxy (thiocarbonyl) thio, or cyclic or acyclic alkanoylamino in which the cyclic and acyclic alkanoylamino group may have a substituent selected from lower alkoxy, aryl, hydroxyaryl; and protected hydroxyaryl; and X is O or S; and pharmaceutically acceptable salt thereof, which are useful in the treatment of hypertension, thrombosis and ulcer in human beings and animals.

  由以下式子表示的新型三嗪衍生物 其中 R' 是氢或卤素； R2是羟基、受保护的羟基、氨基、氰基、巯基、低级烷硫基、芳基硫基、氨基磺酰基、低级烷基磺酰基氨基、低级烷基脲基、芳基脲基、低级烷基硫脲基、芳基硫脲基、低级烯酰胺基、低级烷氧基羰基氨基、低级烷氧基（硫代羰基）硫基或环状或无环状烷酰胺基。 其中环状和非环状烷酰基氨基可具有选自低级烷氧基、芳基、羟基芳基和受保护羟基芳基的取代基；以及 X 是 O 或 S； 及其药学上可接受的盐，可用于治疗人类和动物的高血压、血栓和溃疡。
• PROCESS FOR PREPARING SULFONAMIDE DERIVATIVE OF NORBORNANE
  申请人：SHIONOGI & CO., LTD.

  公开号：EP0557519A1

  公开（公告）日：1993-09-01

  A process for preparing a sulfonamide derivative of a norbornane represented by formula (I), (wherein R' represents optionally protected CH₂OH or COOH; R² represents optionally substituted phenyl; and Y represents oxygen or optionally substituted methylene), which comprises treating under Hofmann rearrangement reaction conditions a norbornane carboxamide represented by formula (II), (wherein R represents optionally protected CH₂OH or COOR¹, R¹ represents hydrogen or an ester-forming group; and Y is as defined above); and reacting the resultant compound with a sulfonyl halide represented by formula (III), (wherein R² is as defined above; and X represents a halogen).

  一种制备由式(I)代表的降冰片烷磺酰胺衍生物的工艺（其中 R'代表任选保护的 CH₂OH 或 COOH；R²代表任选取代的苯基；其中 R 代表任选保护的 CH₂OH 或 COOR¹，R¹ 代表氢或成酯基团；Y 如上文所定义）；并将所得化合物与式 (III) 所代表的磺酰卤反应（其中 R² 如上文所定义；X 代表卤素）。
• Novel amide and amidine derivates and uses thereof
  申请人：Abbott Laboratories

  公开号：EP2243479A2

  公开（公告）日：2010-10-27

  The present invention relates to inhibitors of 11- β-hydroxysteroid dehydrogenase type 1 enzyme and their use in treatment of non-insulin dependent type 2 diabetes, insulin resistance, obesity, lipid disorders, metabolic syndrome, central nervous system disorders, and diseases and conditions that are related to excessive glucocorticoids.

  本发明涉及11-β-羟类固醇脱氢酶1型酶的抑制剂及其在治疗非胰岛素依赖型2型糖尿病、胰岛素抵抗、肥胖、血脂紊乱、代谢综合征、中枢神经系统紊乱以及与糖皮质激素过多有关的疾病和病症中的用途。
• PROCESS OF PRODUCING POLYOLEFINS USING METALLOCENE POLYMERIZATION CATALYSTS AND COPOLYMERS THEREFROM
  申请人：ExxonMobil Chemical Patents Inc.

  公开号：EP3428202A1

  公开（公告）日：2019-01-16

  An ethylene copolymer, a Group 4 transition metal catalyst compound, and methods for polymerization using such a catalyst compound, said catalyst compound represented by the formula: represented by the formula: wherein each R1, R2, R3, and R4 is, independently, hydrogen, a hydrocarbyl group, a substituted hydrocarbyl group, aryl group, substituted aryl group, or a heteroatom-containing group, provided that any of adjacent R1, R2, R3, and R4 groups may form a fused ring or multicenter fused ring system where the rings may be aromatic, partially saturated or saturated; M is a Group 4 transition metal; z is 0, 1, 2, 3, 4, 5, 6, 7, or 8 indicating the number of R' groups bound to the bridging group T, p is 1, 2 or 3 indicating the number of L groups bound to the bridging group T; each X is, independently, selected from the group consisting of hydrocarbyl radicals having from 1 to 20 carbon atoms, hydrides, amides, alkoxides, sulfides, phosphides, halides, dienes, amines, phosphines, ethers, and combinations thereof, provided that two X's may form a part of a fused ring or a ring system; T is a bridging group; each R' is, independently, hydrogen, a C1 to C10 alkyl group, a C6 to C24 aryl group, or a C7 to C40 alkylaryl group; each L is selected from the L-list, and JS'z*-1-y is a heteroatom ligand in which J is an element from Group 15 with a coordination number of 3 or an element from Group 16 with a coordination number of 2; S' is a radical group which is a hydrocarbyl, substituted hydrocarbyl, or heteroatom; and z* is the coordination number of the element J, and y is 0 or 1, are provided.

  一种乙烯共聚物、一种第 4 族过渡金属催化剂化合物以及使用这种催化剂化合物进行聚合的方法，所述催化剂化合物由式表示： 式表示： 其中每个 R1、R2、R3 和 R4 独立地为氢、烃基、取代的烃基、芳基、取代的芳基或含杂原子的基团，条件是相邻的 R1、R2、R3 和 R4 基团中的任一基团可形成融合环或多中心融合环体系，其中的环可以是芳香的、部分饱和的或饱和的；M 是第 4 族过渡金属；z 是 0、1、2、3、4、5、6、7 或 8，表示与桥基 T 结合的 R'基团的数目，p 是 1、2 或 3，表示与桥基 T 结合的 L 基团的数目；每个 X 独立地选自由 1 至 20 个碳原子的烃基、氢化物、酰胺、烷氧基化物、硫化物、磷化物、卤化物、二烯、胺、膦、醚及其组合组成的组，但两个 X 可构成一个融合环或一个环系统的一部分；T 是桥接基团；每个 R' 独立地是氢、C1 至 C10 烷基、C6 至 C24 芳基或 C7 至 C40 烷芳基；每个 L 选自 L 列表，JS'z*-1-y 是杂原子配体，其中 J 是配位数为 3 的第 15 组元素或配位数为 2 的第 16 组元素；S'是基团，该基团是烃基、取代的烃基或杂原子；z* 是 J 元素的配位数，y 是 0 或 1。