5,7-Dihydroxy-3-(4-hydroxyphenyl)chromen-4-one;7-hydroxy-3-(4-hydroxyphenyl)chromen-4-one

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 异黄酮类化合物
• 英文名称: 5,7-Dihydroxy-3-(4-hydroxyphenyl)chromen-4-one;7-hydroxy-3-(4-hydroxyphenyl)chromen-4-one
• 化学式: C30H20O9
• 分子量: 524.5
• InChiKey: ACDPRYCQMKKTBT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.45
• 重原子数：
  39
• 可旋转键数：
  2
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  154
• 氢给体数：
  5
• 氢受体数：
  9

文献信息

• Composition for and method of preventing or treating breast cancer
  申请人：Protein Technologies International, Inc.

  公开号：EP1159963A1

  公开（公告）日：2001-12-05

  The present invention is a composition for preventing, minimising, or reversing the development or growth of breast cancer. The composition contains a combination of a selective estrogen receptor modulator selected from at least one of raloxifene, droloxifene, toremifene, 4'-iodotamoxifen, and idoxifene and at least one isoflavone selected from genistein, daidzein, biochanin A, formononetin, and their respective naturally occurring glucosides and glucoside conjugates. The present invention also provides a method of preventing, minimising, or reversing the development or growth of breast cancer in which a selective estrogen receptor modulator selected from at least one of raloxifene, droloxifene, toremifene, 4'-iodotamoxifen, and idoxifene is co-administered with at least one isoflavone selected from genistein, daidzein, biochanin A, formononetin, and their naturally occurring glucosides and glucoside conjugates to a woman having or predisposed to having breast cancer.

  本发明是一种用于预防、减少或逆转乳腺癌发展或生长的组合物。该组合物包含一种选择性雌激素受体调节剂的组合，该选择性雌激素受体调节剂选自雷洛昔芬、屈洛昔芬、托瑞米芬、4'-碘他莫昔芬和伊多昔芬中的至少一种，以及至少一种异黄酮，该异黄酮选自genistein、daidzein、biochanin A、formononetin，以及它们各自天然存在的葡萄糖苷和葡萄糖苷结合物。本发明还提供了一种预防、减少或逆转乳腺癌发展或生长的方法，在该方法中，选自雷洛昔芬（raloxifene）、屈洛昔芬（droloxifene）、托瑞米芬（toremifene）、4'-碘他莫昔芬（4'-iodotamoxifen）中至少一种的选择性雌激素受体调节剂与伊多昔芬（idoxifene）同时服用、和依多昔芬中的至少一种异黄酮共同施用给患乳腺癌或易患乳腺癌的妇女。
• Miso with good flavor containing high amount of isoflavone compounds
  申请人：Ichijo Noriyoshi

  公开号：US20050031766A1

  公开（公告）日：2005-02-10

  The purpose of the present invention is to obtain miso with good flavor containing large quantities of isoflavone compounds, which has decreased bitter taste derived from the isoflavone. The present invention relates to miso with good flavor containing large quantities of isoflavone compounds, which is produced by adding 0.1% to 5.0% (W/W) isoflavone compounds (e.g., genistin, daidzin, and glycitin, and aglycons of these compounds including genistein, daidzein, glycitein, and the like) and dried and fermented fish such as dried bonito or boiled-dried fish or a treated product thereof (e.g., a hot water extract of dried and fermented fish or an alcohol extract of dried and fermented fish) to miso, and relates to a method for producing the same.

  本发明的目的是获得含有大量异黄酮化合物的风味良好的味噌，这种味噌的异黄酮产生的苦味有所减少。本发明涉及含有大量异黄酮化合物的风味良好的味噌，它是通过添加 0.1%至 5.0%（W/W）的异黄酮化合物（例如、本发明涉及在味噌中加入 0.1%至 5.0%（W/W）的异黄酮化合物（例如，染料木素、染料木素和甘柠素，以及这些化合物的缩合物，包括染料木素、染料木素、甘柠素等）和发酵鱼干，如鲣鱼干或煮熟的鱼干或其处理产品（例如，发酵鱼干的热水提取物或发酵鱼干的酒精提取物），从而生产出具有良好风味的味噌，本发明还涉及生产这种味噌的方法。
• US6300367B1
  申请人：——

  公开号：US6300367B1

  公开（公告）日：2001-10-09
• US6849281B2
  申请人：——

  公开号：US6849281B2

  公开（公告）日：2005-02-01
• US7056952B1
  申请人：——

  公开号：US7056952B1

  公开（公告）日：2006-06-06