金硫丁二钠 | 12244-57-4

• 物质功能分类: 有机原料 - 有机金属盐
• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 中文名称: 金硫丁二钠
• 中文别名: 金硫苹果酸钠；金(I)硫丁二酸钠
• 英文名称: Aurothiomalate sodium
• CAS: 12244-57-4
• 化学式: C4H6AuNaO4S
• 分子量: 370.11
• InChiKey: AATVVBHCZDQBFG-UHFFFAOYSA-N

物化性质

• 颜色/状态：
  White to yellowish-white powder; mixture of mono- and disodium salts
• 气味：
  Odorless
• 味道：
  Metallic taste
• 溶解度：
  Very soluble in water; practically insoluble in alcohol, ether
• 稳定性/保质期：

  在常温常压下稳定，应避免接触酸碱、氧化物和金属粉末。

计算性质

• 辛醇/水分配系数(LogP)：
  -0.54
• 重原子数：
  11
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  75.6
• 氢给体数：
  3
• 氢受体数：
  5

ADMET

代谢

对于接受金钠硫代硫酸盐治疗的病人来说，尿中的主要金物种是[Au(CN)2]-，这种物质也出现在血液的低分子量浸润中。

For a patient receiving gold sodium thiomalate the principal gold species in the urine is [Au(CN)2]-, which is also seen in a low molecular weight infiltrate of the blood

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 解毒与急救

当对金出现严重反应时，可能会给予皮质类固醇、二巯基丙醇（一种螯合剂）或青霉胺以帮助恢复。推荐使用泼尼松……来管理对金严重肾脏、血液、肺部或肠结肠反应。当单独使用皮质类固醇治疗无效时，可以同时使用二巯基丙醇和皮质类固醇来促进金的移除。

When severe reactions to gold occur, corticosteroids, dimercaprol (a chelating agent), or penicillamine may be given to aid recovery. Prednisone ... is recommended to manage severe renal, hematologic, pulmonary, or enterocolic reactions to gold. Dimercaprol may be used together with corticosteroids to facilitate removal of the gold when corticosteroid treatment alone is ineffective.

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 解毒与急救

当出现毒性反应时，应立即停止使用黄色素钠/金硫代马酸盐/治疗。诸如局部皮炎、轻度口腔炎或轻微蛋白尿等轻微并发症通常不需要其他治疗，随着黄色素钠/金硫代马酸盐/的停用会自行解决。中重度皮肤和粘膜反应通常可以通过局部使用皮质类固醇、口服抗组胺药以及舒缓或麻醉乳膏来缓解。

Treatment with myochrysine /gold sodium thiomalate/ should be discontinued immediately when toxic reactions occur. Minor complications such as localized dermatitis, mild stomatitis or slight proteinuria generally require no other therapy and resolve spontaneously with suspension of myochrysine /gold sodium thiomalate/. Moderately severe skin and mucous membrane reactions often benefit from topical corticosteroids, oral antihistaminics, and soothing or anesthetic lotions.

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 解毒与急救

对于严重的肾脏、血液、肺和肠炎并发症，建议使用大剂量的系统性皮质类固醇。皮质类固醇治疗的最佳持续时间因个别患者的反应而异。当不良反应异常严重或进展时，可能需要数月的治疗。

For serious renal, hematologic, pulmonary, and enterocolitic complications, high doses of systemic corticosteroids are recommended. The optimum duration of corticosteroid treatment varies with response of the individual patient. Therapy may be required for many months when adverse effects are unusually severe or progressive.

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 解毒与急救

在那些并发症在高剂量皮质类固醇治疗下没有改善的患者中，或者那些出现显著类固醇相关不良反应的患者中，可以给予螯合剂以增强金排泄。二巯基丙醇（BAL）已成功使用，但必须仔细监测患者，因为可能会有许多不良反应伴随其使用。皮质类固醇和螯合剂可以同时使用。

In patients whose complications do not improve with high dose corticosteroid treatment, or who develop significant steroid related adverse reactions, a chelating agent may be given to enhance gold excretion. Dimercaprol (BAL) has been used successfully, but patients must be monitored carefully as numerous untoward reactions may attend it use. Corticosteroids and chelating agents may be used concomitantly.

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 医疗监测

由于金中毒引起的血液病态罕见，但由于可能产生的严重后果，必须在治疗期间通过频繁的血液检查来持续监测和早期识别。已经报道了粒细胞减少症、血小板减少症（伴或不伴紫癜）、嗜酸性粒细胞增多、再生障碍性贫血和骨髓增生低下性贫血。这些反应可能会单独发生或组合出现。

Blood dyscrasia due to gold toxicity is rare, but because of the potential serious consequences it must be constantly watched for and recognized early by frequent blood examinations done throughout treatment. granulocytopenia, thrombocytopenia with or without purpura, eosinophilia, and hypoplastic and aplastic anemia, have been reported. These reactions may occur separately of in combinations.

来源:Hazardous Substances Data Bank (HSDB)

吸收、分配和排泄

更高组织水平出现在使用注射金盐的情况下，平均稳态血浆水平为1至5微克/毫升。药物广泛分布于全身，包括淋巴结、骨髓、肾脏、肝脏、脾脏和各组织。大约85%至90%的药物与蛋白质结合。

Higher tissue levels occur with parenteral gold salts, with a mean steady state plasma level of 1 to 5 ug/ml. Drug is distributed widely throughout the body in lymph nodes, bone marrow, kidneys, liver, spleen, and tissues. About 85% to 90% is protein-bound.

来源:Hazardous Substances Data Bank (HSDB)

吸收、分配和排泄

金钠硫代苹果酸盐在孕妇体内的金已被证明可以穿过胎盘。在接受金钠硫代苹果酸盐的妇女中，已经证明有少量金分布到乳汁中。

Gold has been shown to cross the placenta in pregnant women receiving gold sodium thiomalate. Small amounts of gold have been shown to be distributed into milk in women receiving ... gold sodium thiomalate.

来源:Hazardous Substances Data Bank (HSDB)

吸收、分配和排泄

金钠硫代硫酸盐溶液在肌内注射后迅速被吸收，血清浓度在3-6小时内达到峰值。

Gold sodium thiomalate solutions are rapidly absorbed following IM injection, with peak serum concentrations occurring in 3-6 hours.

来源:Hazardous Substances Data Bank (HSDB)

吸收、分配和排泄

在给予单次10毫克剂量的金钠硫代硫酸盐后，血清金浓度显示出双相下降，一个相对较快的早期阶段（血清半衰期约为43小时）和一个缓慢的晚期阶段（血清半衰期约为6天）。下降的慢速阶段可能是由于排泄，而快速下降阶段可能是由于组织分布。金化合物的真正累积潜力，包括金钠硫代硫酸盐，尚未被明确界定，但很明显，在给予 parenteral 金化合物治疗期间，与给予 auranofin 治疗期间相比，身体中保留的金量要大得多。

Following single 10-mg doses of gold sodium thiomalate, serum gold concentrations showed a biphasic decline with a relatively rapid early phase (serum half-life about 43 hours) and a slow late phase (serum half-life about 6 days). The slow phase of decline may result from excretion and the rapid phase of decline may result from tissue distribution. The true potential of gold compounds, including ... gold sodium thiomalate, to cumulate has not been clearly defined, but it is clear that substantially larger amounts of gold are retained in the body during therapy with parenteral gold compounds than during therapy with auranofin.

来源:Hazardous Substances Data Bank (HSDB)

安全信息

• 危险品标志：
  Xn
• 安全说明：
  S36
• 危险类别码：
  R20/21/22,R43
• WGK Germany：
  3
• RTECS号：
  MD5435000
• 海关编码：
  2930909090
• 危险性防范说明：
  P261,P264,P270,P271,P272,P280,P363,P302+P352,P304+P340,P312,P330,P403,P501
• 危险性描述：
  H317,H302+H332

SDS

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Section 1. Chemical Product and Company Identification
Gold sodium thiomalate Catalog
G1033, G1062
Common Name/
Number(s).
Trade Name
CAS# 12244-57-4
Manufacturer
RTECS MD5435000
SPECTRUM CHEMICAL MFG. CORP.
TSCA TSCA 8(b) inventory: No
products were found.
Commercial Name(s) Not available.
CI# Not available.
Synonym Sodium aurothiomalate
IN CASE OF EMERGENCY
Mixture of mono- and disodium salts of gold thiomalate
Chemical Name
Chemical Family Not available. CALL [phone]
C4H3AuNa2O4S
Chemical Formula
SPECTRUM CHEMICAL MFG. CORP.

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Section 2.Composition and Information on Ingredients
Exposure Limits
TWA (mg/m3) STEL (mg/m3) CEIL (mg/m3)
Name CAS # % by Weight
1) Gold sodium thiomalate 12244-57-4 100
Toxicological Data Gold sodium thiomalate
on Ingredients LD50: Not available.
LC50: Not available.

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Section 3. Hazards Identification
Potential Acute Health Effects Hazardous in case of skin contact (irritant), of eye contact (irritant), of ingestion, of inhalation (lung irritant).
Slightly hazardous in case of skin contact (permeator).
Potential Chronic Health CARCINOGENIC EFFECTS: Not available.
Effects MUTAGENIC EFFECTS: Not available.
TERATOGENIC EFFECTS: Not available.
DEVELOPMENTAL TOXICITY: Not available.
Repeated or prolonged exposure is not known to aggravate medical condition.
Gold sodium thiomalate

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Section 4. First Aid Measures
Eye Contact Check for and remove any contact lenses. Immediately flush eyes with running water for at least 15 minutes,
keeping eyelids open. Cold water may be used. Do not use an eye ointment. Seek medical attention.
Skin Contact After contact with skin, wash immediately with plenty of water. Gently and thoroughly wash the contaminated skin
with running water and non-abrasive soap. Be particularly careful to clean folds, crevices, creases and groin.
Cold water may be used. Cover the irritated skin with an emollient. If irritation persists, seek medical attention.
Wash contaminated clothing before reusing.
Serious Skin Contact Wash with a disinfectant soap and cover the contaminated skin with an anti-bacterial cream. Seek medical
attention.
Inhalation Allow the victim to rest in a well ventilated area. Seek immediate medical attention.
Serious Inhalation Not available.
Ingestion Do not induce vomiting. Loosen tight clothing such as a collar, tie, belt or waistband. If the victim is not
breathing, perform mouth-to-mouth resuscitation. Seek immediate medical attention.
Serious Ingestion Not available.

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Section 5. Fire and Explosion Data
Flammability of the Product May be combustible at high temperature.
Auto-Ignition Temperature Not available.
Flash Points Not available.
Flammable Limits Not available.
These products are carbon oxides (CO, CO2). Some metallic oxides.
Products of Combustion
Fire Hazards in Presence of Not available.
Various Substances
Explosion Hazards in Presence Risks of explosion of the product in presence of mechanical impact: Not available.
of Various Substances Risks of explosion of the product in presence of static discharge: Not available.
Fire Fighting Media SMALL FIRE: Use DRY chemical powder.
and Instructions LARGE FIRE: Use water spray, fog or foam. Do not use water jet.
Special Remarks on Not available.
Fire Hazards
Special Remarks on Explosion Not available.
Hazards

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Section 6. Accidental Release Measures
Small Spill Use appropriate tools to put the spilled solid in a convenient waste disposal container. Finish cleaning by
spreading water on the contaminated surface and dispose of according to local and regional authority
requirements.
Large Spill
Use a shovel to put the material into a convenient waste disposal container. Finish cleaning by spreading water
on the contaminated surface and allow to evacuate through the sanitary system.
Gold sodium thiomalate

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Section 7. Handling and Storage
Precautions Keep away from heat. Keep away from sources of ignition. Empty containers pose a fire risk, evaporate the
residue under a fume hood. Ground all equipment containing material. Do not breathe dust. Wear suitable
protective clothing In case of insufficient ventilation, wear suitable respiratory equipment If you feel unwell, seek
medical attention and show the label when possible. Avoid contact with skin and eyes
Storage Keep container dry. Keep in a cool place. Ground all equipment containing material. Keep container tightly
closed. Keep in a cool, well-ventilated place. Combustible materials should be stored away from extreme heat
and away from strong oxidizing agents.

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Section 8. Exposure Controls/Personal Protection
Engineering Controls Use process enclosures, local exhaust ventilation, or other engineering controls to keep airborne levels below
recommended exposure limits. If user operations generate dust, fume or mist, use ventilation to keep exposure to
airborne contaminants below the exposure limit.
Personal Protection Splash goggles. Lab coat. Dust respirator. Be sure to use an approved/certified respirator or equivalent.
Gloves.
Personal Protection in Case of Splash goggles. Full suit. Dust respirator. Boots. Gloves. A self contained breathing apparatus should be used
a Large Spill to avoid inhalation of the product. Suggested protective clothing might not be sufficient; consult a specialist
BEFORE handling this product.
Exposure Limits Not available.

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Section 9. Physical and Chemical Properties
Physical state and appearance Solid. (Powdered solid.) Odor Odorless.
Taste Not available.
390.08 g/mole
Molecular Weight
Color White to yellowish.
pH (1% soln/water) 5.5 [Acidic.]
Boiling Point Decomposes.
Melting Point 300°C (572°F)
Critical Temperature Not available.
Specific Gravity Not available.
Not applicable.
Vapor Pressure
Vapor Density Not available.
Volatility 0% (v/v). 0% (w/w).
Odor Threshold Not available.
Water/Oil Dist. Coeff. Not available.
Not available.
Ionicity (in Water)
Dispersion Properties See solubility in water.
Easily soluble in cold water, hot water.
Solubility

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Section 10. Stability and Reactivity Data
The product is stable.
Stability
Instability Temperature Not available.
Not available.
Conditions of Instability
Incompatibility with various Not available.
substances
Gold sodium thiomalate
Corrosivity Non-corrosive in presence of glass.
Special Remarks on Not available.
Reactivity
Special Remarks on Not available.
Corrosivity
Polymerization No.

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Section 11. Toxicological Information
Routes of Entry Eye contact. Inhalation. Ingestion.
Toxicity to Animals LD50: Not available.
LC50: Not available.
Chronic Effects on Humans Not available.
Other Toxic Effects on Hazardous in case of skin contact (irritant), of ingestion, of inhalation (lung irritant).
Humans Slightly hazardous in case of skin contact (permeator).
Special Remarks on Not available.
Toxicity to Animals
Special Remarks on Not available.
Chronic Effects on Humans
Special Remarks on other Not available.
Toxic Effects on Humans

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Section 12. Ecological Information
Ecotoxicity Not available.
BOD5 and COD Not available.
Products of Biodegradation Possibly hazardous short term degradation products are not likely. However, long term degradation products may
arise.
Toxicity of the Products The products of degradation are more toxic.
of Biodegradation
Special Remarks on the Not available.
Products of Biodegradation

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Section 13. Disposal Considerations
Waste Disposal

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Section 14. Transport Information
DOT Classification Not a DOT controlled material (United States).
Identification Not applicable.
Special Provisions for Not applicable.
Transport
Gold sodium thiomalate
DOT (Pictograms)

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Section 15. Other Regulatory Information and Pictograms
No products were found.
Federal and State
Regulations
California California prop. 65: This product contains the following ingredients for which the State of California has found
to cause cancer which would require a warning under the statute: No products were found.
Proposition 65
Warnings
California prop. 65: This product contains the following ingredients for which the State of California has found
to cause birth defects which would require a warning under the statute: No products were found.
Other Regulations EINECS: This product is on the European Inventory of Existing Commercial Chemical Substances.
WHMIS (Canada) Not controlled under WHMIS (Canada).
Other Classifications
DSCL (EEC) R36/37/38- Irritating to eyes,
respiratory system and skin.
Health Hazard
HMIS (U.S.A.) 2 National Fire Protection
1 Flammability
1 Association (U.S.A.)
Fire Hazard
2 0 Reactivity
Health
Reactivity
0
Specific hazard
Personal Protection
E
WHMIS (Canada)
(Pictograms)
DSCL (Europe)
(Pictograms)
TDG (Canada)
(Pictograms)
ADR (Europe)
(Pictograms)
Protective Equipment
Gloves.
Lab coat.
Dust respirator. Be sure to use an
approved/certified respirator or
equivalent.
Gold sodium thiomalate

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SECTION 16 - ADDITIONAL INFORMATION
N/A