(-)-羟基乙酸薄荷酯 | 64850-52-8

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 中文名称: (-)-羟基乙酸薄荷酯
• 英文名称: (-)-Menthyl hydroxyacetate
• 英文别名: (-)-menthyl glycolate；glycolic acid-((1R)-menthyl ester)；Glykolsaeure-((1R)-menthylester)；[(1R,2S,5R)-5-methyl-2-propan-2-ylcyclohexyl] 2-hydroxyacetate
• CAS: 64850-52-8
• 化学式: C₁₂H₂₂O₃
• 分子量: 214.305
• InChiKey: FMATXKUIGQODAH-OUAUKWLOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  15
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.92
• 拓扑面积：
  46.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  (-)-羟基乙酸薄荷酯 在 phosphorus pentoxide 、 二甲基亚砜 作用下， 以 二氯甲烷 为溶剂， 以71%的产率得到(1R)-(-)-薄荷基乙醛酸
  参考文献：
  名称：

  The (-)-Menthyl Ester Group as a Chiral Auxiliary in Electrophilic Glycine Derivatives

  摘要：

  DOI：

  10.1002/prac.19943360317
• 作为产物：
  描述：

  羟基乙酸 、 L-薄荷醇 在 对甲苯磺酸 作用下， 以 甲苯 为溶剂， 以85%的产率得到(-)-羟基乙酸薄荷酯
  参考文献：
  名称：

  The (-)-Menthyl Ester Group as a Chiral Auxiliary in Electrophilic Glycine Derivatives

  摘要：

  DOI：

  10.1002/prac.19943360317

文献信息

• New and efficient approaches to the semisynthesis of taxol and its C-13 side chain analogs by means of β-lactam synthon method
  作者：Iwao Ojima、Ivan Habus、Mangzhu Zhao、Martine Zucco、Young Hoon Park、Chung Ming Sun、Thierry Brigaud

  DOI：10.1016/s0040-4020(01)91210-4

  日期：1992.1

  Highly efficient chiral ester enolate-imine condensation giving 3-hydroxy-4-aryl-β-lactams with excellent enantiomeric purity is successfully applied to the asymmetric synthesis of the enantiomerically pure taxol C-13 side chain, N-benzoyl-(2R,3S)-3-phenyl-isoserine and its analogs. (3R,4S)-N-benzoyl-3-(1-ethoxyethoxy)-4-phenyl-2-azetidinone readily derived from the 3-hydroxy-4-phenyl-β-lactam is coupled

  高效手性酯烯酸酯-亚胺缩合可产生具有优异对映体纯度的3-羟基-4-芳基-β-内酰胺，已成功用于对映体纯紫杉醇C-13侧链N-苯甲酰基-（2 R， 3 S）-3-苯基-异丝氨酸及其类似物。易于衍生自3-羟基-4-苯基-β-内酰胺的（3 R，4 S）-N-苯甲酰基-3-（1-乙氧基乙氧基）-4-苯基-2-氮杂环丁酮与受保护的浆果赤霉素III偶联，然后通过脱保护得到光学纯的紫杉醇和高产率的10-脱乙酰基7,10-双（Troc）-紫杉醇。完全分配的1 H，13显示并讨论了由此合成的紫杉醇的C和2D（COSY和HETCOR）NMR光谱。
• Antiperspirant cosmetics comprising specific proteins from legumes of the genus Pisum and/or Phaseolus and/or Vigna and/or Macrotyloma or from cruciferous plants of the genus Brassica and including no aluminum and/or zirconium halides and/or hydroxy halides
  申请人：Henkel AG & Co. KGaA

  公开号：US10123958B2

  公开（公告）日：2018-11-13

  The present invention relates to an antiperspirant cosmetic agent including at least one specific protein from legumes of the genus Pisum and/or Phaseolus and/or Vigna and/or Macrotyloma or from cruciferous plants of the genus Brassica and including no aluminum and/or zirconium halides and/or hydroxyhalides. The present invention further relates to the use of a specific protein and to a non-therapeutic method for reducing body perspiration. Adding or using said at least one specific protein ensures that the sweat gland(s) are effectively influenced, thus resulting in a significant reduction in axillary sweat even in the absence of antiperspirant aluminum salts.

  本发明涉及一种止汗化妆品剂，其中包括至少一种来自豆科植物（Pisum 和/或 Phaseolus 和/或 Vigna 和/或 Macrotyloma）或十字花科植物（Brassica）的特定蛋白质，并且不包括铝和/或卤化锆和/或羟基卤化物。本发明进一步涉及一种特定蛋白质的使用和一种减少人体出汗的非治疗方法。添加或使用所述至少一种特定蛋白质可确保汗腺受到有效影响，从而即使在没有止汗剂铝盐的情况下也能显著减少腋汗。
• Antiperspirants having increased effectiveness
  申请人：Henkel AG & Co. KGaA

  公开号：US10238594B2

  公开（公告）日：2019-03-26

  The present disclosure relates to antiperspirant cosmetic agents, in the case of which the total amount of antiperspirant compounds can be clearly reduced without the antiperspirant effect of said agents or the storage stability of said agents being impaired, comprising—in each case with respect to the total weight of the antiperspirant cosmetic agent—a) 1 to 30 wt % of at least one antiperspirant compound, b) 0.1 to 10 wt % of salicylic acid, c) at least one compound of formula (I), in which n represents 0 or 1, X represents —H, Na+, K+, or NH4+, R1 is selected from —H, —COOX, or —(CH2)—COOX, R2 is selected from —H, C1-10 alkyl, or COOX, R3 is selected from —(CH2)—COOX, —(CH2)2-N[(CH2)—COOX]2, —CH(R1)—COOX, —(CH2)2-NH[CH(COOX)(CH2COOX)], —CH(R4)—C(R5)(R6)—COOX, R4 is selected from —H, C1-10 alkyl, or COOX, and R5 and R6 are, independently of each other, —H, —OH, or C1-10 alkyl.

  本公开涉及止汗剂化妆品制剂，其中止汗剂化合物的总量可明显减少，而不会损害所述制剂的止汗效果或所述制剂的贮存稳定性，包括--在每种情况下相对于止汗剂化妆品制剂的总重量--a) 1 至 30 wt % 的至少一种止汗剂化合物，b) 0.1 至 10 wt % 的水杨酸，c) 至少一种式 (I) 化合物，其中 n 代表 0 或 1，X 代表 -H、Na+、K+ 或 NH4+，R1 选自 -H、-COOX 或 -(CH2)-COOX，R2 选自 -H、C1-10 烷基或 COOX、R3 选自-( )-COOX、-( )2-N[( )-COOX]2、-CH(R1)-COOX、-( )2-NH[CH(COOX)( COOX)]、-CH(R4)-C(R5)(R6)-COOX，R4 选自-H、C1-10 烷基或 COOX，R5 和 R6 相互独立地为-H、-OH 或 C1-10 烷基。
• Cosmetic antiperspirants with alkylsuphonic acids
  申请人：Henkel AG & Co. KGaA

  公开号：US10357446B2

  公开（公告）日：2019-07-23

  The present invention concerns a cosmetic antiperspirant composition comprising at least one substance selected from the group consisting of cosmetic oils which are liquid at 20° C. and 1,013 hPa, odorants and waxes, at least one antiperspirant aluminum salt in a total amount of 1 to 80 wt %, based on the total weight of the cosmetic antiperspirant composition, and at least one compound of the formula (S-I), in which X+ is H+, Li+, Na+, K+, NH4+, ½ Mg2+, ½ Ca2+, ½ Mn2+, ½ Zn2+, ⅓ Al3+, ¼ Zr4+ or at least one antiperspirant aluminum salt and R1 is a linear or branched, saturated or unsaturated alkyl group having 1 to 10 carbon atoms, the addition of the at least one compound of the formula (S-I) resulting in effective activation of the at least one antiperspirant aluminum salt, in eminent stabilization of this activated state and in outstanding sweat diminution.

  本发明涉及一种化妆品止汗剂组合物，该组合物包含至少一种选自化妆品油（在 20° C.和 1,013 hPa 下呈液态的化妆品油、气味剂和蜡，至少一种止汗剂铝盐，其总量为 1 至 80 wt %（基于化妆品止汗剂组合物的总重量），以及至少一种式 (S-I) 的化合物，其中 X+ 是 H+、Li+、Na+、K+、NH4+、½ Mg2+、½ Ca2+、½ Mn2+、½ Zn2+、⅓ Al3+、¼ Zr4+ 或至少一种止汗剂铝盐，且 R1 是具有 1 至 10 个碳原子的直链或支链、饱和或不饱和烷基，加入至少一种式（S-I）化合物可有效活化至少一种止汗剂铝盐，显著稳定这种活化状态，并明显减少出汗。
• Use of polysaccharides in antiperspirant cosmetic agents for protecting textiles
  申请人：Henkel AG & Co. KGaA

  公开号：US10688322B2

  公开（公告）日：2020-06-23

  The present invention relates to the use of a polysaccharide selected from the group of non-modified polysaccharides, chemically modified polysaccharides and physically modified polysaccharides, in antiperspirant cosmetic agents, the use of these polysaccharides resulting in an excellent reduction and/or prevention of textile discoloration and/or textile stains.

  本发明涉及一种选自非改性多糖、化学改性多糖和物理改性多糖的多糖在止汗剂化妆品中的使用，使用这些多糖可以很好地减少和/或防止纺织品褪色和/或纺织品污渍。