(1R,2S,3S,4R,8S,9S,12R)-4,8-二甲基-13-亚甲基四环[10.2.1.0(1,9).0(3,8)]十五烷-2,4-二甲酸 | 1164-45-0

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 中文名称: (1R,2S,3S,4R,8S,9S,12R)-4,8-二甲基-13-亚甲基四环[10.2.1.0(1,9).0(3,8)]十五烷-2,4-二甲酸
• 中文别名: 赤霉素A12
• 英文名称: gibberellin A12
• 英文别名: GA₁₂；(1R,2S,3S,4R,8S,9S,12R)-4,8-dimethyl-13-methylidenetetracyclo[10.2.1.01,9.03,8]pentadecane-2,4-dicarboxylic acid
• CAS: 1164-45-0
• 化学式: C₂₀H₂₈O₄
• 分子量: 332.44
• InChiKey: UJFQJDAESQJXTG-UFUZVNNQSA-N

物化性质

• 沸点：
  474.9±38.0 °C(Predicted)
• 密度：
  1.23±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  24
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  74.6
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  (1R,2S,3S,4R,8S,9S,12R)-4,8-二甲基-13-亚甲基四环[10.2.1.0(1,9).0(3,8)]十五烷-2,4-二甲酸 在 Fusarium fujikuroi Δcpr mutant 作用下， 以 甲醇 为溶剂， 反应 72.0h， 生成 赤霉素A15标准品 、 赤霉素A(24)
  参考文献：
  名称：

  电子传递蛋白对藤黑镰刀菌赤霉素单加氧酶催化反应的影响

  摘要：

  来自 Fujikuroi 镰刀菌的多功能细胞色素 P450 单加氧酶 P450-1 和 P450-2 分别催化赤霉素 (GA) 生物合成途径中 GA14 和 GA4 的形成。然而，与含有 CPR 的菌株相比，这些酶的活性在缺乏 NADPH:细胞色素 P450 氧化还原酶 (CPR) 的突变体中在质量和数量上是不同的。3beta-羟基化是野生型菌株中主要的 P450-1 活性，相对于 C-6 和 C-7 处的氧化，突变体中强烈降低，而 C19-GAs 的合成是由于 C-20 的氧化裂解P450-2 几乎不存在，而 C-20 醇、醛和羧酸衍生物积累。单加氧酶与替代电子传递蛋白的相互作用可以解释这些不同的产物分布。在没有心肺复苏术的情况下，P450-1 活性是 NADH 依赖性的，并受到细胞色素 b5 或添加的 FAD 的刺激。这些特性以及突变体中 P450-1 和 P450-2 的效率降低与细胞色素

  DOI：

  10.1016/j.phytochem.2007.08.026
• 作为产物：
  描述：

  3,5-二羟基-3-甲基戊酸 在 cell-free system of Phaseolus coccineus 、 K-Pi buffer 、 还原型辅酶II(NADPH)四钠盐 、 bovine serum albumin 作用下， 反应 2.0h， 生成 kaurene 、 (1R,2S,3S,4R,8S,9S,12R)-4,8-二甲基-13-亚甲基四环[10.2.1.0(1,9).0(3,8)]十五烷-2,4-二甲酸 、 贝壳杉烯酸 、 ent-kaura-6,16-dien-19-oic acid
  参考文献：
  名称：

  Turnbull, Colin G. N.; Crozier, Alan; Schwenen, Ludger, Phytochemistry, 1986, vol. 25, # l, p. 97 - 102

  摘要：

  DOI：

文献信息

• PRODUCTION OF GIBBERELLINS IN RECOMBINANT HOSTS
  申请人：Evolva SA

  公开号：EP3423475A2

  公开（公告）日：2019-01-09
• Wound and skin care products
  申请人：Malik Sohail

  公开号：US20070082852A1

  公开（公告）日：2007-04-12

  The invention provides compositions and methods that employ compounds that can stimulate proliferation of fibroblasts or keratinocytes and/or stimulate production of collagen by fibroblasts. These compositions and methods are useful for treating gum- and skin-related conditions.
• Identification of compounds for inhibiting complexation of C-reactive protein with fibronectin
  申请人：Boga RameshBabu

  公开号：US20070134813A1

  公开（公告）日：2007-06-14

  Disclosed are screening processes for identification of compounds that may inhibit complex formation between C-reactive protein and fibronectin. Compounds identified by the disclosed methods may be utilized to inhibit the target analytes that are known to occur during skin aging as well as during the course of several diseases. Accordingly, inhibitory compounds identified by the disclosed methods may be utilized to prevent and treat damaged tissue, inflammatory conditions, cardiovascular conditions, renal conditions, periodontal conditions and obesity, among other conditions. For example, the compounds identified by the disclosed methods may be utilized to treat tissue that has suffered trauma, e.g., burns or wounds, as well as tissue that is inflamed due to any of several causes. The disclosed compounds may also be utilized to improve the accuracy of assays designed to assess CRP or Fn levels in a sample, for instance in a plasma sample, as a risk assessment tool in certain medical conditions and to discover new treatments.
• Methods for controlling gibberellin levels
  申请人：Brown M. Sherri

  公开号：US20070174931A1

  公开（公告）日：2007-07-26

  Methods and materials are disclosed for the inhibition and control of gibberellic acid levels. In particular, nucleic acid sequences of copalyl diphosphate synthase. 3-β hydroxylase, and 2-oxidase and additional nucleic acid sequences are disclosed. Gibberellic acid levels may be inhibited or controlled by preparation of a chimeric expression construct capable of expressing a RNA or protein product which suppresses the gibberellin biosynthetic pathway sequence, diverts substrates from the pathway or degrades pathway substrates or products. The sequence is preferably a copalyl diphosphate synthase sequence, a 3β-hydroxylase sequence, a 2-oxidase sequence, a phytoene synthase sequence, a C20-oxidase sequence, and a 2β,3β-hydroxylase sequence. Administration of a complementing agent, preferably a gibberellin or gibberellin precursor or intermediate restores bioactivity.
• POTATO TRANSCRIPTION FACTORS, METHODS OF USE THEREOF, AND A METHOD FOR ENHANCING TUBER DEVELOPMENT
  申请人：HANNAPEL David J.

  公开号：US20080184396A1

  公开（公告）日：2008-07-31

  The present invention relates to isolated nucleic acid molecules which encode a BEL transcription factor from potato ( Solanum tuberosum L.) and the amino acid sequences encoded by such nucleic acid molecules. Additional aspects of the present invention relate to methods of using isolated nucleic acid molecules which encode BEL transcription factors from potato to enhance growth and to regulate flowering in plants. The present invention is also directed to a method for enhancing tuber development in a plant. This method includes transforming a tuberous plant with a DNA construct including a nucleic acid molecule encoding a BEL transcription factor or a KNOX transcription factor, and an operably linked promoter and 3′ regulatory region, whereby tuber development is enhanced in the plant.