山豆根色满二氢黄酮Ⅰ,山豆根素 | 23057-55-8

• 物质功能分类: 生物化工 - 提取物 - 植物提取物
• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 黄酮类化合物
• 中文名称: 山豆根色满二氢黄酮Ⅰ,山豆根素
• 中文别名: (-)-山豆根素
• 英文名称: sophoranone
• 英文别名: (2S)-7-hydroxy-2-[4-hydroxy-3,5-bis(3-methylbut-2-enyl)phenyl]-8-(3-methylbut-2-enyl)-2,3-dihydrochromen-4-one
• CAS: 23057-55-8
• 化学式: C₃₀H₃₆O₄
• 分子量: 460.613
• InChiKey: IORSRBKNYXPSDO-NDEPHWFRSA-N

物化性质

• 沸点：
  644.5±55.0 °C(Predicted)
• 密度：
  1.117±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  8
• 重原子数：
  34
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.37
• 拓扑面积：
  66.8
• 氢给体数：
  2
• 氢受体数：
  4

安全信息

• WGK Germany：
  3

反应信息

• 作为反应物：
  描述：

  山豆根色满二氢黄酮Ⅰ,山豆根素 、 乙酸酐 在 吡啶 作用下， 以45 mg的产率得到Sophoranon-diacetat
  参考文献：
  名称：

  Flavonoids from Millettia pulchra

  摘要：

  DOI：

  10.1016/s0031-9422(00)80349-0

文献信息

• Herbal compositions useful as chemopreventive and therapeutic agents and methods of manufacturing same
  申请人：Global Cancer Strategies Ltd.

  公开号：US20030099725A1

  公开（公告）日：2003-05-29

  Compositions derived from traditional Chinese herbal medicines, medicinal plants and extracts thereof, are provided for the prevention and treatment of cancers especially cancer of the lung, esophagus, stomach, oral cavity and prostate as well as for treating Helicobacter pylori infection. The compositions of the invention are obtained through specific techniques and have demonstrated efficacy for chemoprevention of cancers of the lung, esophagus, stomach, and the oral cavity as well as exhibiting in vitro activity against prostate cancer and leukemic cell lines. The compositions are useful as adjuncts to conventional surgery or radiotherapy treatments in patients with esophageal cancer. The compositions are effective as a treatment for H. pylori infection. Currently, there is no effective chemopreventive agent for these cancers. The current invention addresses a special need in cancer control. Preferred compositions of the invention contain the herbal ingredients Sophora tonkinensis, Polygonum bistorta, Prunella vulgaris, Sonchus brachyotus, Dictamnus dasycarpus Turcz, and Dioscorea bulbifera.

  本发明提供了从传统中草药、药用植物及其提取物中提取的组合物，用于预防和治疗癌症，特别是肺癌、食管癌、胃癌、口腔癌和前列腺癌，以及治疗幽门螺杆菌感染。本发明的组合物通过特定技术获得，并已证明对肺癌、食管癌、胃癌、口腔癌具有化学预防功效，并在体外表现出对前列腺癌和白血病细胞系的活性。该组合物可作为食管癌患者常规手术或放疗治疗的辅助治疗。该组合物对H. pylori感染有效。目前没有有效的化学预防剂可用于这些癌症。本发明解决了癌症控制中的特殊需求。本发明的优选组合物包含草药Sophora tonkinensis、Polygonum bistorta、Prunella vulgaris、Sonchus brachyotus、Dictamnus dasycarpus Turcz和Dioscorea bulbifera的成分。
• Process for the manufacture of a herbal composition
  申请人：——

  公开号：US20040170704A1

  公开（公告）日：2004-09-02

  The present invention is concerned with a process for the manufacture of a herbal composition, said process comprising: a. subjecting a matrine containing plant material, in the absence of a plant material derived from the species Dictamnus, to an extraction with an aqueous solvent, optionally followed by a concentration step, to produce a herbal extract I; b. subjecting a plant material derived from the species Dictamnus, to an extraction with an aqueous solvent, optionally followed by a concentration step, to produce a herbal extract II; c. mixing the herbal extracts I and II; d. provided the resulting mixture contains a significant amount of water, drying the mixture to a water content of less than 6 wt. %. The herbal composition according to the present invention may advantageously be used in a method of treating or preventing cancer, H. pylori infections, chronic inflammatory conditions, cardiovascular diseases or cerebral vascular diseases in mammals.

  本发明涉及一种制造草药组合物的过程，该过程包括：a. 在不含来自紫茉莉属物种的植物材料的情况下，将含有苦参碱的植物材料用水溶剂进行提取，可选地进行浓缩步骤，以产生草药提取物I; b. 将来自紫茉莉属物种的植物材料用水溶剂进行提取，可选地进行浓缩步骤，以产生草药提取物II; c. 混合草药提取物I和II; d. 如果所得混合物含有大量水，将混合物干燥至水含量小于6重量％。本发明的草药组合物可以优势地用于治疗或预防哺乳动物的癌症、H. pylori感染、慢性炎症疾病、心血管疾病或脑血管疾病的方法中。
• Use of coconut water as extraction solvent
  申请人：BASF Beauty Care Solutions France SAS

  公开号：US10981084B2

  公开（公告）日：2021-04-20

  The present invention relates to the use of coconut water as extraction solvent, to extraction methods using coconut water and extracts obtained by extraction with coconut water.

  本发明涉及使用椰子水作为萃取溶剂、使用椰子水的萃取方法以及通过椰子水萃取获得的提取物。
• Methods for botanical and/or algae extraction
  申请人：BASF CORPORATION

  公开号：US11234918B2

  公开（公告）日：2022-02-01

  The present disclosure relates to methods for extraction of biomass. Biomass of most interest is that which contains biologically active, extracts suitable for the skin care market. The biomass of interest includes botanicals (plant extracts and bioferments thereof), algae (red, brown, green and red, including bioferments thereof), fungi and even animal extracts (insect, crustacean) origin. Further the use of said extracts in cosmetic preparations prepared by the disclosed method is envisioned.

  本公开涉及提取生物质的方法。最令人感兴趣的生物质是含有适合护肤品市场的生物活性提取物的生物质。生物质包括植物（植物提取物及其生物发酵物）、藻类（红藻、褐藻、绿藻和红藻，包括其生物发酵物）、真菌，甚至动物（昆虫、甲壳类动物）提取物。此外，还可以将上述提取物用于通过所公开方法制备的化妆品制剂中。
• Methods of use of herbal compositions
  申请人：Fong A.T. Andy

  公开号：US20050025823A1

  公开（公告）日：2005-02-03

  The present invention relates to herbal composition and methods of administering an herbal composition, comprising geranium oil and extracts from roots of the plants of the genus Sophora, particularly S. flavescenes and S. tonkinensis, to humans and other mammalian animals with gastric ulcers induced by H. pylori infection. The same composition is shown to be able to eradicate H. pylori in vitro. The invention also relates to a composition comprising citronellol and extracts from roots of Sophora plants. The present invention further relates to the use of citronellol to inhibit gastric ulcers. The invention also relates to the use of the same composition to inhibit the enzymatic activity of Na + /K + -ATPase to strengthen heart muscle contractions and prevent heart failure.

  本发明涉及草药组合物和草药组合物的施用方法，该草药组合物由天竺葵油和槐属植物根的提取物组成。 槐属植物根部的提取物、 特别是 S. flavescenes 和 S. tonkinensis、 对人类和其他因幽门螺杆菌诱发胃溃疡的哺乳动物的影响 幽门螺杆菌 感染的人类和其他哺乳动物的胃溃疡。同样的成分还能根除 幽门螺杆菌 体外根除幽门螺杆菌。本发明还涉及一种由香茅醇和槐根提取物组成的组合物。 槐 植物根部的提取物。本发明还涉及使用香茅醇抑制胃溃疡。本发明还涉及使用相同的组合物抑制 Na + /K + -ATP酶的酶活性，以加强心肌收缩和预防心力衰竭。