(7aS,12aS)-3,3-二甲基-3H,7H-苯并呋喃并[3,2-c]吡喃并[3,2-g][1]苯并吡喃-7a,10(12aH)-二醇 | 67314-98-1

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 异黄酮类化合物
• 中文名称: (7aS,12aS)-3,3-二甲基-3H,7H-苯并呋喃并[3,2-c]吡喃并[3,2-g][1]苯并吡喃-7a,10(12aH)-二醇
• 英文名称: glyceollin II
• 英文别名: 3,3-Dimethyl-3H,7H-benzofuro[3,2-c]pyrano[3,2-g][1]benzopyran-7a,10(12aH)-diol, 9CI；17,17-dimethyl-3,12,16-trioxapentacyclo[11.8.0.02,10.04,9.015,20]henicosa-1(13),4(9),5,7,14,18,20-heptaene-6,10-diol
• CAS: 67314-98-1
• 化学式: C₂₀H₁₈O₅
• 分子量: 338.36
• InChiKey: DDJVLBCETGUEBO-UHFFFAOYSA-N

物化性质

• 沸点：
  519.9±50.0 °C(Predicted)
• 密度：
  1.397±0.06 g/cm3(Predicted)
• 物理描述：
  Solid
• 熔点：
  89-93°C

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  25
• 可旋转键数：
  0
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  68.2
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• Compositions and Methods for Treating Obesity and Diabetes
  申请人：BUROW Matthew E.

  公开号：US20110237505A1

  公开（公告）日：2011-09-29

  Disclosed are methods of modulating the expression of genes linked to adipocytokine signaling, carbohydrate metabolism, fatty acid metabolism, arachidonic acid metabolism, PPAR signaling, insulin signaling, lipid metabolism, extracellular matrix (ECM)-receptor interaction, or combinations thereof, methods of treating hyperlipidemia, obesity, excessive cholesterol, cardiovascular disease, liver disease, diabetes, or combinations thereof, and methods of stimulating glucose uptake in an animal in need thereof, comprising administering a composition comprising at least one isolated glyceollin to said animal.
• Glyceollins Suppress Androgen-Responsive Prostate Cancer
  申请人：Cleveland Thomas E.

  公开号：US20130041022A1

  公开（公告）日：2013-02-14

  The present disclosure demonstrates the molecular effects of glyceollins on human prostate cancer cell LNCaP to further elucidate its potential effects on prostate cancer prevention. The glyceollins inhibited LNCaP cell growth similar to that of the soy isoflavone genistein. The growth inhibitory effects of the glyceollins appeared to be due to an inhibition on G1/S progression and correlated with an up-regulation of cyclin-dependent kinase inhibitor A1 and B1 mRNA and protein levels. By contrast, genistein only up-regulates cyclin-dependent kinase inhibitor A1. In addition, glyceollin treatments led to down-regulated mRNA levels for androgen responsive genes. In contrast to genistein, this effect of glyceollins on androgen responsive genes appeared to be mediated through modulation of an estrogen- but not androgen-mediated pathway. Hence, the glyceollins exerted multiple effects on LNCaP cells that may be considered cancer preventive and the mechanisms of action appeared to be different from other soy-derived phytochemicals.
• US8987198B2
  申请人：——

  公开号：US8987198B2

  公开（公告）日：2015-03-24