(9Z)-N-(1-甲基乙基)-9-十八碳烯酰胺 | 10574-01-3

• 物质功能分类: 有机原料 - 氨基化合物 - 酰胺类化合物
• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 中文名称: (9Z)-N-(1-甲基乙基)-9-十八碳烯酰胺
• 英文名称: N-Isopropyloleamide
• 英文别名: (9Z)-N-isopropyl-9-octadecenamide；(Z)-N-isopropyl-octadec-9-enamide；N-isopropyl-oleyl amide；(Z)-N-Isopropyl-9-octadecenamide；(Z)-N-propan-2-yloctadec-9-enamide
• CAS: 10574-01-3
• 化学式: C₂₁H₄₁NO
• 分子量: 323.563
• InChiKey: FJMNGVBYKSEJNP-QXMHVHEDSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.8
• 重原子数：
  23
• 可旋转键数：
  16
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  29.1
• 氢给体数：
  1
• 氢受体数：
  1

安全信息

• 海关编码：
  2924199090

反应信息

• 作为产物：
  描述：

  油酸 、 异丙胺 在 乙醇 作用下， 反应 6.0h， 以80%的产率得到(9Z)-N-(1-甲基乙基)-9-十八碳烯酰胺
  参考文献：
  名称：

  A catalyst-free, waste-less ethanol-based solvothermal synthesis of amides

  摘要：

  一种绿色的、一锅法的乙醇基溶剂热酰胺化反应，不需要催化剂或偶联试剂。

  DOI：

  10.1039/c7gc02967e

文献信息

• New endocannabinoid-like compounds and their use
  申请人：RESEARCH & INNOVATION SOC. COOP. A R.L.

  公开号：EP1900365A2

  公开（公告）日：2008-03-19

  The present invention describes compounds deriving from chemical reactions between saturated or monounsaturated acyl derivatives and primary amines or primary alcohols that display specific cannabinoid-like pharmacological activity without exhibiting the central unwanted side effects typical of synthetic cannabinoids or endocannabinoids acting on central cannabinoid (CB1) receptors. These compounds, having this pharmacological activity, may be utilised to prevent or to treat pathological conditions and diseases in mammals, including human subjects, that may undergo a clinical improvement upon their administration.

  本发明描述了由饱和或单不饱和酰基衍生物与伯胺或伯醇之间的化学反应所产生 的化合物，这些化合物显示出类似大麻素的特殊药理活性，而不会表现出合成大麻 素或作用于中枢大麻素（CB1）受体的内源性大麻素所特有的中枢性不良副作用。这些具有这种药理活性的化合物可用于预防或治疗哺乳动物（包括人类）的病理状况和疾病，服用后可改善临床症状。
• Corrosion inhibitors
  申请人：RHODIA OPERATIONS

  公开号：US10017681B2

  公开（公告）日：2018-07-10

  The instant invention relates to the use of a compound selected from C2-C30 alkyl phosphonic acids, salts thereof, esters thereof, and mixtures thereof, to inhibit corrosion of a metal component by an aqueous fluid containing dissolved gases in an industrial hydrocarbon system.

  本发明涉及一种选自 C2-C30 烷基膦酸的化合物、其盐类、酯类及其混合物，用于抑制工业碳氢化合物系统中含有溶解气体的水性流体对金属部件的腐蚀。
• Surfactant composition
  申请人：RHODIA OPERATIONS

  公开号：US10174596B2

  公开（公告）日：2019-01-08

  The invention provides a synergistic surfactant composition comprising: (a) a first amphoteric surfactant, which is selected from C8-C22 sultaines, salts thereof, and mixtures thereof; and (b) a second amphoteric surfactant, which is selected from C8-C22 betaines and salts thereof, C8-C22 propionates and salts thereof, and mixtures thereof. This surfactant composition may be used to generate foam that is used for unloading a liquid from a hydrocarbon reservoir. It may be that the liquid unloading of foam generated using the surfactant composition is greater than that of foam generated from the first and second surfactants when they are foamed individually.

  本发明提供了一种增效表面活性剂组合物，它包括：(a) 第一种两性表面活性剂，它选自 C8-C22 脂肪烷烃、其盐和它们的混合物；(b) 第二种两性表面活性剂，它选自 C8-C22 甜菜碱及其盐、C8-C22 丙酸盐及其盐和它们的混合物。这种表面活性剂组合物可用来产生泡沫，用于从碳氢化合物储层中卸载液体。使用该表面活性剂组合物产生的泡沫的液体卸载能力可能大于第一种和第二种表面活性剂单独发泡产生的泡沫。
• USE OF ENDOCANNABINOID-LIKE COMPOUNDS FOR TREATING CNS DEGENERATIVE DISORDERS
  申请人：Research & Innovation S.p.A.

  公开号：EP1592418B1

  公开（公告）日：2017-09-06
• Evaluation of endogenous fatty acid amides and their synthetic analogues as potential anti-inflammatory leads
  作者：Hung The Dang、Gyeoung Jin Kang、Eun Sook Yoo、Jongki Hong、Jae Sue Choi、Hyung Sik Kim、Hae Young Chung、Jee H. Jung

  DOI：10.1016/j.bmc.2010.12.046

  日期：2011.2

  A series of endogenous fatty acid amides and their analogues (1-78) were prepared, and their inhibitory effects on pro-inflammatory mediators (NO, IL-1 beta, IL-6, and TNF-alpha) in LPS-activated RAW264.7 cells were evaluated. Their inhibitory activity on the pro-inflammatory chemokine MDC in IFN-gamma-activated HaCaT cells was also examined. The results showed that the activity is strongly dependent on the nature of the fatty acid part of the molecules. As expected, the amides derived from enone fatty acids showed significant activity and were more active than those derived from other types of fatty acids. A variation of the amine headgroup also altered bioactivity profile remarkably, possibly by modulating cell permeability. Regarding the amine part of the molecules, N-acyl dopamines exhibited the most potent activity (IC50 similar to 2 mu M). This is the first report of the inhibitory activity of endogenous fatty acid amides and their analogues on the production of nitric oxide, cytokines (IL-1 beta, IL-6, and TNF-alpha) and the chemokine MDC. This study suggests that the enone fatty acid-derived amides (such as N-acyl ethanolamines and N-acyl amino acids) and N-acyl dopamines may be potential anti-inflammatory leads. (C) 2010 Elsevier Ltd. All rights reserved.