3-[2-hydroxy-4-methoxy-3-(3-methylbut-2-enyl)phenyl]-5-methoxy-6-(3-methylbut-2-enyl)-3,4-dihydro-2H-chromen-7-ol

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 异黄酮类化合物
• 英文名称: 3-[2-hydroxy-4-methoxy-3-(3-methylbut-2-enyl)phenyl]-5-methoxy-6-(3-methylbut-2-enyl)-3,4-dihydro-2H-chromen-7-ol
• 化学式: C₂₇H₃₄O₅
• 分子量: 438.6
• InChiKey: JIFZHRYUIHKKCM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.8
• 重原子数：
  32
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.41
• 拓扑面积：
  68.2
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• ISOFLAVANE DERIVATIVES AND IMMUNOPOTENTIATING COMPOSITIONS CONTAINING THE SAME
  申请人：SHIONOGI & CO., LTD.

  公开号：EP1057825A1

  公开（公告）日：2000-12-06

  An objective of the present invention is to provide a specific compound and composition for the prevention or therapy of diseases associated with immunodeficiency. Isoflavan derivatives which are a glycyrrhiza extract and chemical derivatives thereof, i.e., a compound represented by general formula (II): [where R1, R2, R3, and R4 may be identical with or different from one another and may each be hydrogen, an alkyl group which may be substituted, an alkenyl group which may be substituted, an alkynyl group which may be substituted, an acyl group which may be substituted, an aralkyl group which may be substituted, or a tri-substituted silyl group; G1, G2, and G3 may be identical with or different from one another and may each be a hydrogen, an acyl group which may be substituted, or an aliphatic hydrocarbon group which may be substituted; symbol (*) indicates the presence of an asymmetric carbon atom, meaning an R form, an S form, or a mixture thereof], or a salt thereof, or a hydrate thereof has immunoactivating actions, and is expected to provide effects as a biophylaxis function promoter by way of lymphocyte function promoting actions and bone marrow function promoting actions.

  本发明的目的是提供一种预防或治疗与免疫缺陷有关疾病的特定化合物和组合物。 异黄烷衍生物是一种甘草提取物及其化学衍生物，即通式（II）所代表的化合物： [其中 R1、R2、R3 和 R4 可以彼此相同或不同，并且可以分别为氢、可被取代的烷基、可被取代的烯基、可被取代的炔基、可被取代的酰基、可被取代的芳烷基或三取代硅烷基；G1、G2 和 G3 可以彼此相同或不同，可以分别为氢、可被取代的酰基或可被取代的脂族烃基；符号（*）表示存在不对称碳原子，意指 R 形式、S 形式或其混合物]，或其盐，或其水合物具有免疫激活作用，并有望通过淋巴细胞功能促进作用和骨髓功能促进作用提供生物预防功能促进剂的效果。