(Z)-2-癸烯酸 | 15790-91-7

• 物质功能分类: 生物化工 - 生化试剂 - 激动剂抑制剂
• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 中文名称: (Z)-2-癸烯酸
• 英文名称: cis-2-decenoic acid
• 英文别名: CDA；(Z)-2-decenoic acid；(Z)-dec-2-enoic acid
• CAS: 15790-91-7
• 化学式: C₁₀H₁₈O₂
• 分子量: 170.252
• InChiKey: WXBXVVIUZANZAU-HJWRWDBZSA-N

物化性质

• 沸点：
  278.6±9.0 °C(Predicted)
• 密度：
  0.936
• 溶解度：
  DMSO：250 mg/mL（1468.43 mM；需要超声）
• LogP：
  3.715 (est)
• 熔点：
  12.0 °C

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  12
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.7
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

安全信息

• WGK Germany：
  1

SDS

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Section 1. IDENTIFICATION OF THE SUBSTANCE/MIXTURE
Product identifiers
Product name : cis-2-Decenoic acid
CAS-No. : 15790-91-7

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Section 2. HAZARDS IDENTIFICATION
Classification of the substance or mixture
Classification according to Regulation (EC) No 1272/2008 [EU-GHS/CLP]
Eye irritation (Category 2)
Classification according to EU Directives 67/548/EEC or 1999/45/EC
Irritating to eyes.
Label elements
Labelling according Regulation (EC) No 1272/2008 [CLP]
Pictogram
Signal word Warning
Hazard statement(s)
Causes serious eye irritation.
Precautionary statement(s)
P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove
contact lenses, if present and easy to do. Continue rinsing.
Supplemental Hazard none
Statements
According to European Directive 67/548/EEC as amended.
Hazard symbol(s)
R-phrase(s)
R36 Irritating to eyes.
S-phrase(s)
S26 In case of contact with eyes, rinse immediately with plenty of water and
seek medical advice.
Other hazards - none

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Section 3. COMPOSITION/INFORMATION ON INGREDIENTS
Substances
Formula : C10H18O2
Molecular Weight : 170,25 g/mol
Component Concentration
cis-2-Decenoic acid
CAS-No. 15790-91-7 -

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Section 4. FIRST AID MEASURES
Description of first aid measures
General advice
Consult a physician. Show this safety data sheet to the doctor in attendance.
If inhaled
If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician.
In case of skin contact
Wash off with soap and plenty of water. Consult a physician.
In case of eye contact
Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.
If swallowed
Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.
Most important symptoms and effects, both acute and delayed
To the best of our knowledge, the chemical, physical, and toxicological properties have not been
thoroughly investigated.
Indication of any immediate medical attention and special treatment needed
no data available

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Section 5. FIREFIGHTING MEASURES
Extinguishing media
Suitable extinguishing media
Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
Special hazards arising from the substance or mixture
Carbon oxides
Advice for firefighters
Wear self contained breathing apparatus for fire fighting if necessary.
Further information
no data available

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Section 6. ACCIDENTAL RELEASE MEASURES
Personal precautions, protective equipment and emergency procedures
Use personal protective equipment. Avoid dust formation. Avoid breathing vapors, mist or gas. Ensure
adequate ventilation. Avoid breathing dust.
Environmental precautions
Do not let product enter drains.
Methods and materials for containment and cleaning up
Pick up and arrange disposal without creating dust. Sweep up and shovel. Keep in suitable, closed
containers for disposal.
Reference to other sections
For disposal see section 13.

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Section 7. HANDLING AND STORAGE
Precautions for safe handling
Avoid contact with skin and eyes. Avoid formation of dust and aerosols.
Provide appropriate exhaust ventilation at places where dust is formed.
Conditions for safe storage, including any incompatibilities
Store in cool place. Keep container tightly closed in a dry and well-ventilated place.
Recommended storage temperature: -20 °C
Air sensitive. Store under inert gas.
Specific end uses
no data available

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Section 8. EXPOSURE CONTROLS/PERSONAL PROTECTION
Control parameters
Components with workplace control parameters
Exposure controls
Appropriate engineering controls
Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and
at the end of workday.
Personal protective equipment
Eye/face protection
Safety glasses with side-shields conforming to EN166 Use equipment for eye protection tested
and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).
Skin protection
Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique
(without touching glove's outer surface) to avoid skin contact with this product. Dispose of
contaminated gloves after use in accordance with applicable laws and good laboratory practices.
Wash and dry hands.
The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and
the standard EN 374 derived from it.
Body Protection
impervious clothing, The type of protective equipment must be selected according to the
concentration and amount of the dangerous substance at the specific workplace.
Respiratory protection
For nuisance exposures use type P95 (US) or type P1 (EU EN 143) particle respirator.For higher
level protection use type OV/AG/P99 (US) or type ABEK-P2 (EU EN 143) respirator cartridges.
Use respirators and components tested and approved under appropriate government standards
such as NIOSH (US) or CEN (EU).

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Section 9. PHYSICAL AND CHEMICAL PROPERTIES
Information on basic physical and chemical properties
a) Appearance Form: solid
b) Odour no data available
c) Odour Threshold no data available
d) pH no data available
e) Melting point/freezing no data available
point
f) Initial boiling point and no data available
boiling range
g) Flash point no data available
h) Evaporation rate no data available
i) Flammability (solid, gas) no data available
j) Upper/lower no data available
flammability or
explosive limits
k) Vapour pressure no data available
l) Vapour density no data available
m) Relative density no data available
n) Water solubility no data available
o) Partition coefficient: n- no data available
octanol/water
p) Autoignition no data available
temperature
q) Decomposition no data available
temperature
r) Viscosity no data available
s) Explosive properties no data available
t) Oxidizing properties no data available
Other safety information
no data available

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Section 10. STABILITY AND REACTIVITY
Reactivity
no data available
Chemical stability
no data available
Possibility of hazardous reactions
no data available
Conditions to avoid
no data available
Incompatible materials
Strong oxidizing agents
Hazardous decomposition products
Other decomposition products - no data available

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Section 11. TOXICOLOGICAL INFORMATION
Information on toxicological effects
Acute toxicity
no data available
Skin corrosion/irritation
no data available
Serious eye damage/eye irritation
no data available
Respiratory or skin sensitization
no data available
Germ cell mutagenicity
no data available
Carcinogenicity
IARC: No component of this product present at levels greater than or equal to 0.1% is identified as
probable, possible or confirmed human carcinogen by IARC.
Reproductive toxicity
no data available
Specific target organ toxicity - single exposure
no data available
Specific target organ toxicity - repeated exposure
no data available
Aspiration hazard
no data available
Potential health effects
Inhalation May be harmful if inhaled. May cause respiratory tract irritation.
Ingestion May be harmful if swallowed.
Skin May be harmful if absorbed through skin. May cause skin irritation.
Eyes Causes serious eye irritation.
Signs and Symptoms of Exposure
To the best of our knowledge, the chemical, physical, and toxicological properties have not been
thoroughly investigated.
Additional Information
RTECS: Not available

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Section 12. ECOLOGICAL INFORMATION
Toxicity
no data available
Persistence and degradability
no data available
Bioaccumulative potential
no data available
Mobility in soil
no data available
Results of PBT and vPvB assessment
no data available
Other adverse effects
no data available

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Section 13. DISPOSAL CONSIDERATIONS
Waste treatment methods
Product
Offer surplus and non-recyclable solutions to a licensed disposal company. Dissolve or mix the material
with a combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber.
Contaminated packaging
Dispose of as unused product.

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Section 14. TRANSPORT INFORMATION
UN number
ADR/RID: - IMDG: - IATA: -
UN proper shipping name
ADR/RID: Not dangerous goods
IMDG: Not dangerous goods
IATA: Not dangerous goods
Transport hazard class(es)
ADR/RID: - IMDG: - IATA: -
Packaging group
ADR/RID: - IMDG: - IATA: -
Environmental hazards
ADR/RID: no IMDG Marine pollutant: no IATA: no
Special precautions for user
no data available

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Section 15. REGULATORY INFORMATION
This safety datasheet complies with the requirements of Regulation (EC) No. 1907/2006.
Safety, health and environmental regulations/legislation specific for the substance or mixture
no data available
Chemical Safety Assessment

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SECTION 16 - ADDITIONAL INFORMATION
N/A

制备方法与用途

生物活性

(Z)-2-癸烯酸 ((Z)-2-Decenoic acid) 是由铜绿假单胞菌产生的一种不饱和脂肪酸。它在由革兰氏阴性细菌（包括铜绿假单胞菌）和革兰氏阳性细菌形成的生物膜中诱导分散反应，并且能够抑制生物膜的发育。

体外研究

当在外源添加 (Z)-2-癸烯酸 ((Z)-2-Decenoic acid) 到浓度为 2.5 nM 的铜绿假单胞菌 PAO1 生物膜时，可以观察到生物膜微殖民地被诱导分散。

反应信息

• 作为反应物：
  描述：

  (Z)-2-癸烯酸 在 盐酸 作用下， 以 乙醚 、 水 为溶剂， 生成 (E)-undec-3-en-2-one
  参考文献：
  名称：

  钯介导的共轭E或Z烯酮和不对称二乙烯基酮的合成。一锅制备异麦草酮

  摘要：

  酰基卤或酸酐与链烯基铜试剂的钯（o）催化偶联可高收率提供α，β乙烯酮和α，β-α，β'二乙烯酮。通过炔烃的羰基化直接获得的烯基铜试剂的取代模式被完全保留。Z-烯酸的酸酐也保留其Z立体化学。β-卤代乙烯基酮在上述条件下反应，得到α，β-γ，δ二烯酮。报道了一种有效的一锅法合成Z或ε异麦角蛋白酮的方法。

  DOI：

  10.1016/s0040-4020(01)87356-7
• 作为产物：
  描述：

  1,3-dibromo-2-decanone 在 lithium hydroxide 作用下， 反应 5.0h， 生成 (Z)-2-癸烯酸
  参考文献：
  名称：

  [EN] METHOD AND COMPOSITION FOR WATER TREATMENT
  [FR] PROCÉDÉ ET COMPOSITION DE TRAITEMENT DE L'EAU

  摘要：

  该发明提供了一种水中微生物控制的方法，包括向水中添加一种或多种基于溴的生物杀灭剂和顺-2-癸烯酸或其盐。还描述了包含基于溴的生物杀灭剂和顺-2-癸烯酸或其盐的液体浓缩物组合物。

  公开号：

  WO2020240559A1

文献信息

• Identification of the Natural Product Rotihibin A as a TOR Kinase Signaling Inhibitor by Unbiased Transcriptional Profiling
  作者：Vivek Halder、Julian Oeljeklaus、Geronimo Heilmann、Jan H. Krahn、Yanlin Liu、Yan Xiong、Markus Schlicht、Jasmin Schillinger、Barbara Kracher、Michael Ehrmann、Erich Kombrink、Farnusch Kaschani、Markus Kaiser

  DOI：10.1002/chem.201802647

  日期：2018.8.27

  a rapid, label‐free, and compound economic evaluation of a natural product′s bioactivity profile in a complex multicellular organism. To this end, we established a chemical synthesis of Rotihibin A as well as that of structural analogues, followed by transcriptional profiling‐guided identification and validation of Rotihibin A as a TOR signaling inhibitor (TOR=target of rapamycin). These findings illustrate

  具有生物活性的天然产物是开发用于生物学研究的化学工具的重要起点。为了阐明其生物活性特征，通常使用具有简洁复杂性的生物系统（例如细胞培养系统），而仅在较复杂的多细胞系统中进行无偏研究的情况很少。在这里，我们用天然产物Rotihibin A和植物研究模型系统拟南芥（Arabidopsis thaliana）进行了演示。无偏见的转录谱分析可以对复杂的多细胞生物中的天然产物的生物活性进行快速，无标记的复合经济评估。为此，我们建立了Rotihibin A和结构类似物的化学合成方法，然后进行转录谱分析指导鉴定和验证Rotihibin A作为TOR信号抑制剂（TOR =雷帕霉素的靶标）。这些发现表明，转录谱分析和天然产物研究的组合方法可能代表一种简化了天然产物化学工具开发的技术简单方法，即使对于生物复杂的多细胞生物系统也是如此。
• [EN] ANTI-MICROBIAL COMPOSITIONS<br/>[FR] COMPOSITIONS ANTIMICROBIENNES
  申请人：5D HEALTH PROT GROUP LTD

  公开号：WO2022023724A1

  公开（公告）日：2022-02-03

  The present invention relates to compounds, compositions, methods of forming/preparing such compounds and compositions, and uses for sanitising and/or substantially removing biofilms and microorganisms living within or around biofilms. The present invention, in particular, relates to compounds of formula Mn(P) as described herein which can be used in wound treatments, wound dressings, medical devices, water treatments, food processing and dental care biofilms.

  本发明涉及化合物、组合物、制备这些化合物和组合物的方法，以及用于消毒和/或大量去除生物膜和生存在生物膜内或周围的微生物的用途。本发明特别涉及如本文所述的公式Mn（P）的化合物，可用于伤口治疗、伤口敷料、医疗器械、水处理、食品加工和牙科护理生物膜。
• PHARMACEUTICAL COMPOSITIONS
  申请人：RHYTHM METABOLIC, INC.

  公开号：US20160022764A1

  公开（公告）日：2016-01-28

  The present invention relates to an ionic complex comprising a cationic polypeptide and an anionic excipient selected from: a PEG-carboxylic acid; a fatty acid having 10 or more carbon atoms; an anionic phospholipid; and a combination thereof. The invention also relates to a pharmaceutical composition comprising the ionic complex of the invention and a pharmaceutically acceptable carrier. The cationic polypeptide of the ionic complex has pharmacological activity and the complex can provide a more desirable pharmacokinetic profile for the cationic polypeptide of the complex as compared to the cationic polypeptide alone following administration. As such, the invention also relates to the use of the ionic complex and pharmaceutical composition comprising same to treat a subject suffering from a disease or disorder that is responsive to the cationic polypeptide of the ionic complex.

  本发明涉及一种离子复合物，包括阳离子多肽和阴离子辅料，所述阴离子辅料选自：PEG-羧酸；具有10个或更多碳原子的脂肪酸；阴离子磷脂；以及其组合物。该发明还涉及一种药物组合物，包括本发明的离子复合物和药学上可接受的载体。离子复合物的阳离子多肽具有药理活性，并且与仅使用阳离子多肽相比，复合物可以提供更理想的药代动力学特性。因此，本发明还涉及使用离子复合物和包括其的药物组合物来治疗对离子复合物的阳离子多肽有反应的疾病或障碍的患者。
• Solvent based coating composition
  申请人：Nippon Paint Co., Ltd.

  公开号：EP0413352A2

  公开（公告）日：1991-02-20

  Disclosed is a solvent based coating composition comprising at least one kind of vinyl polymer and an organic solvent, wherein any one of said vinyl polymer has at least one kind selected from the group consisting of an active hydrogen-containing group and a substituted acylamide group, and said vinyl polymer contains the above described two kinds of group as a whole.

  本发明公开了一种溶剂型涂料组合物，该组合物包含至少一种乙烯基聚合物和一种有机溶剂，其中任一种所述乙烯基聚合物具有至少一种从活性含氢基团和取代的酰酰胺基团组成的组中选出的基团，且所述乙烯基聚合物整体包含上述两种基团。
• Aqueous dispersion coating composition
  申请人：Nippon Paint Co., Ltd.

  公开号：EP0413351A2

  公开（公告）日：1991-02-20

  Disclosed is an aqueous dispersion coating composition comprising at least one kind of resins, wherein any one of said resins has at least one kind selected from the group consisting of an active hydrogen-containing group, a substituted acylamide group and a water dispersible or water-soluble group, and said resin composition contains the above described kinds of group as a whole.

  本发明公开了一种水性分散涂料组合物，该组合物包含至少一种树脂，其中任一种树脂具有至少一种选自活性含氢基团、取代的酰酰胺基团和水分散或水溶性基团组成的组的基团，且所述树脂组合物整体包含上述基团。