1,1-二碘戊烷 | 66688-35-5

• 分子结构分类: 有机化合物 - 有机卤素化合物 - 有机碘化物
• 中文名称: 1,1-二碘戊烷
• 英文名称: 1,1-diiodopentane
• 英文别名: diiodopentane；Pentane diiodide
• CAS: 66688-35-5
• 化学式: C₅H₁₀I₂
• 分子量: 323.943
• InChiKey: QGZMPDWGZXYBQS-UHFFFAOYSA-N

物化性质

• 熔点：
  9°C (estimate)
• 沸点：
  269.7°C (estimate)
• 密度：
  2.1060

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  7
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

反应信息

• 作为反应物：
  描述：

  1,1-二甲基硅杂环丁烷 二甲基三亚甲基硅烷 、 1,1-二碘戊烷 在 正丁基锂 、 二异丙胺 作用下， 生成 2-butyl-2-iodo-1,1-dimethyl-1-silacyclopentane
  参考文献：
  名称：

  硅杂环丁烷与锂类胡萝卜素的反应立体选择性形成硅杂环戊烷

  摘要：

  向1，1-二甲基-1-硅环丁烷和二碘甲烷的溶液中加入二异丙基氨基锂，可以得到高产率的1，1-二甲基-2-碘-1-硅环戊烷。

  DOI：

  10.1016/s0040-4039(00)98027-4
• 作为产物：
  描述：

  Pentanal hydrazone 在 碘 作用下， 生成 1,1-二碘戊烷
  参考文献：
  名称：

  Synthesis and reaction chemistry of a new class of .mu.-alkylidene dicobalt complexes. Crystal and molecular structure of (.mu.-methylene)bis[.eta.5-(methylcyclopentadienyl)carbonylcobalt]

  摘要：

  DOI：

  10.1021/ja00341a028

文献信息

• Magnesium promoted cyclopropanation reactions of allylic alcohols
  作者：Carsten Bolm、Doris Pupowicz

  DOI：10.1016/s0040-4039(97)10009-0

  日期：1997.10

  Treatment of allylic alcohols 1 with various magnesium reagents in the presence of alkyl dihalides affords the corresponding cyclopropyl alcohols 2. Reactions occur under mild conditions, and excellent diastereoselectivities have been achieved.

  在烷基二卤化物的存在下用各种镁试剂处理烯丙醇1得到相应的环丙醇2。反应在温和的条件下发生，并且已经实现了出色的非对映选择性。
• Piperazine- and piperidine-derivatives as melanocortin receptor agonists
  申请人：——

  公开号：US20040082590A1

  公开（公告）日：2004-04-29

  The present invention relates to melanocortin receptor agonists of formula I, which is useful in the treatment of obesity, diabetes and male and/or female sexual dysfunction. 1

  本发明涉及公式I的黑素皮质素受体激动剂，可用于治疗肥胖症、糖尿病以及男性和/或女性性功能障碍。
• Synthesis and activity of an HIV-1 Protease inhibitor containing a contiguous (E)-olefin-hydroxyethylene peptide mimetic
  作者：Richard M. Keenan、Daniel F. Eppley、Thaddeus A. Tomaszek

  DOI：10.1016/0040-4039(94)02416-9

  日期：1995.2

  To investigate the contribution of a key amide bond to HIV Protease inhibition, we designed and synthesized a novel (E)-olefin hydroxyethylene analog. The stereoselective synthesis of this interesting homoallylic alcohol structural motif as well as its biological activity are discussed.

  为了调查关键酰胺键对HIV蛋白酶抑制的贡献，我们设计并合成了一种新型的（E）-烯烃羟乙烯类似物。讨论了这种有趣的均丙醇结构基序的立体选择性合成及其生物学活性。
• Carbocupration/Zinc Carbenoid Homologation and β-Elimination Reactions for a New Synthesis of Allenes − Application to the Enantioselective Synthesis of Chiral Allenes by Deracemization of sp3-Organometallic Derivatives
  作者：Jos P. Varghese、Irena Zouev、Lionel Aufauvre、Paul Knochel、Ilan Marek

  DOI：10.1002/1099-0690(200212)2002:24<4151::aid-ejoc4151>3.0.co;2-s

  日期：2002.12

  straightforward carbocupration/zinc homologation/β-elimination reaction sequence allows the one-pot synthesis of polysubstituted allenes from acetylenic sulfoxides in excellent isolated chemical yields. Secondary zinc carbenoids were used for the homologation reaction, and so a new synthesis of 1,1-diiodoalkanes is described. This methodology also allows the synthesis of chiral allenes through thermodynamic

  一种新的、直接的碳化/锌同系化/β-消除反应序列允许从炔亚砜以优异的分离化学产率一锅法合成多取代的丙二烯。二级锌卡宾用于同系化反应，因此描述了 1,1-二碘烷烃的新合成。该方法还允许通过二级有机金属衍生物的热力学平衡来合成手性丙二烯。(© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2002)
• 4-Arylcyclohexylamines
  申请人：The Upjohn Company

  公开号：US03979444A1

  公开（公告）日：1976-09-07

  The invention relates to novel 4-hydroxymethyl(acyloxymethyl and methyl)-4-arylcyclohexylamines embraced by the formula ##SPC1## Wherein Ar is an aromatic ring selected from the group consisting of phenyl and naphthyl, each of which has from zero through three substituents independently selected from the group consisting of fluorine, chlorine, bromine, lower alkyl of one through three carbon atoms, lower alkoxy of one through three carbon atoms, and lower alkylthio of one through three carbon atoms; Z is selected from the group consisting of hydrogen, hydroxy and lower acyloxy of one through four carbon atoms; .about. is a generic expression denoting cis and trans stereoconfiguration and mixtures thereof, with the proviso that when the stereoconfiguration of the linkage connecting the cyclohexane ring and CH.sub.2 Z is cis to the amino group, the linkage connecting the cyclohexane and Ar rings is trans, and vice versa; R.sup.1 is selected from the group consisting of hydrogen and lower alkyl of one through three carbon atoms; R.sup.2 is selected from the group consisting of hydrogen, lower alkyl of one through three carbon atoms, ##EQU1## WHEREIN N IS 2 THROUGH 5 AND Ar has the same meaning as above; R.sup.1 and R.sup.2 taken together with --N< is a saturated heterocyclic amino radical selected from the group consisting of unsubstituted and substituted pyrrolidino, piperidino, hexamethylenimino, morpholino and piperazino; and pharmacologically acceptable acid addition salts thereof. It also relates to intermediates and processes for the preparation of the aforesaid novel compounds (I) and novel derivatives thereof. The administration to humans and animals of the novel compounds (I) depresses their central nervous systems and lowers their blood pressures.

  该发明涉及一种新型4-羟甲基(酰氧甲基和甲基)-4-芳基环己胺，其化学式如下：其中Ar是从苯基和萘基中选择的芳香环，每个环上独立选择的取代基包括氟、氯、溴、1至3个碳原子的低烷基、1至3个碳原子的低烷氧基和1至3个碳原子的低烷基硫基；Z选择自氢、羟基和1至4个碳原子的低酰氧基；~表示顺式和反式立体构型及其混合物，但当连接环己烷环和CH2Z的立体构型为顺时，连接环己烷环和Ar环的连接是反式，反之亦然；R1选择自氢和1至3个碳原子的低烷基；R2选择自氢、1至3个碳原子的低烷基、其中N为2至5且Ar的含义与上述相同；R1和R2与-N<一起构成从未取代和取代的吡咯啉基、哌啶基、六亚甲基基、吗啉基和哌嗪基中选择的饱和杂环氨基基团；以及其药理学上可接受的酸盐。它还涉及中间体和用于制备上述新化合物(I)及其新衍生物的过程。将该新型化合物(I)用于人类和动物，可抑制其中枢神经系统并降低其血压。