1,2,4-三异丙基苯 | 948-32-3

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 中文名称: 1,2,4-三异丙基苯
• 英文名称: 1,2,4-triisopropylbenzene
• 英文别名: 1,2,4-Triisopropylbenzol；1,2,4-tri(propan-2-yl)benzene
• CAS: 948-32-3
• 化学式: C₁₅H₂₄
• 分子量: 204.356
• InChiKey: RWGMANKDYBWNNP-UHFFFAOYSA-N

物化性质

• 熔点：
  -0.02°C (estimate)
• 沸点：
  244°C
• 密度：
  0.8574
• 保留指数：
  1201

计算性质

• 辛醇/水分配系数(LogP)：
  5.3
• 重原子数：
  15
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

安全信息

• 海关编码：
  2902909090

反应信息

• 作为反应物：
  描述：

  1,2,4-三异丙基苯 在 三氯化铝 、 硝酸 作用下， 生成 间苯二甲酸
  参考文献：
  名称：

  Polyisopropylbenzenes. I. Preparation and Properties of Two Di-, Two Tri-, and One Tetra-isopropylbenzene¹

  摘要：

  DOI：

  10.1021/ja01243a005
• 作为产物：
  描述：

  三異丙苯 在 三氯化铝 作用下， 生成 1,2,4-三异丙基苯
  参考文献：
  名称：

  Nesterova; Pimerzin; Krasnykh, Russian Journal of Applied Chemistry, 1999, vol. 72, # 11, p. 1884 - 1890

  摘要：

  DOI：

文献信息

• 4-hydroxytetrahydropyran-2-ones and the corresponding
  申请人：Hoechst Aktiengesellschaft

  公开号：US05294724A1

  公开（公告）日：1994-03-15

  4-Hydroxytetrahydropyran-2-ones and the corresponding dihydroxycarboxylic acid derivatives, salts and esters, process for their preparation, their use as pharmaceuticals, and pharmaceutical preparations and precursors. Compounds of the formula I ##STR1## and the corresponding open-chain dihydroxycarboxylic acids of the formula II ##STR2## in which X, Y, R.sup.1, R.sup.2, R.sup.3, R.sup.4 and R.sup.5 have the meanings indicated, and also their pharmacologically tolerable salts with bases and their pharmacologically tolerable esters, processes for the preparation of these compounds, their use as pharmaceuticals and pharmaceutical preparations are described. In addition, compounds of the formula III ##STR3## in which R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, X and Y have the meanings indicated are described.

  4-羟基四氢吡喃-2-酮及其对应的二羟基羧酸衍生物、盐和酯，其制备方法，作为药物的用途，以及药物制剂和前体。公式I的化合物##STR1##以及公式II的对应的开链二羟基羧酸##STR2##其中X、Y、R.sup.1、R.sup.2、R.sup.3、R.sup.4和R.sup.5具有指示的含义，以及它们与碱形成的药理学可耐受的盐和药理学可耐受的酯，这些化合物的制备方法，它们作为药物的用途以及药物制剂均已描述。此外，公式III的化合物##STR3##其中R.sup.1、R.sup.2、R.sup.3、R.sup.4、R.sup.5、X和Y具有指示的含义。
• Arylation of Phenols. Convenient, Regiospecific Methods for Mono- or Bis-<i>p</i>-fluorophenylations, Suitable for Large Scale Syntheses
  作者：Heiner Jendralla、Li-Jian Chen

  DOI：10.1055/s-1990-27028

  日期：——

  Phenols have been arylated by a palladium(0)-catalyzed coupling reaction. Two methods were used: a Grignard reagent of a protected phenol component 2 was coupled with a haloarene, or an umpolung (reversed reactivity) where unprotected phenolic halides 6 were coupled with aryl Grignard reagents. Bis-arylation and regiospecific ortho-, meta- and para-arylations were achieved. Aryl-aryl couplings were insensitive to steric hindrance in the Grignard component, but were inhibited by sulfur-containing substituents in the phenolic component. A thiocyanate substituted biaryl was used to synthesize arylated phenols with various sulfur functionalities.

  苯酚通过钯（0）催化的偶联反应实现了芳基化。使用了两种方法：一种是将受保护的苯酚成分 2 的格氏试剂与卤代烃偶联，另一种是将未受保护的酚卤化物 6 与芳基格氏试剂偶联的umpolung（反向反应）。在此过程中，实现了双芳基化和特定区域的正芳基化、偏芳基化和对位芳基化。 芳基-芳基偶联对格氏试剂中的立体阻碍不敏感，但会受到酚类试剂中含硫取代基的抑制。硫氰酸盐取代的双芳基被用来合成具有各种硫官能团的芳基化苯酚。
• Process for synthesizing diisopropylbenzene
  申请人：Bennett Quentin Ronald

  公开号：US20050075522A1

  公开（公告）日：2005-04-07

  This invention relates to a process for synthesizing para-diisopropylbenzene utilizing only cumene and propylene as raw materials. This synthesis technique offers the advantage of eliminating benzene as a raw material used in the process. The elimination of benzene is beneficial because it simplifies the process and eliminates the need to purchase and store benzene for use in the synthesis. The elimination of benzene from the synthesis is of particular value since the use of benzene in industrial applications has been under attack on the basis of environmental, safety, and health concerns. The present invention discloses a process for producing para-diisopropylbenzene from cumene and propylene, said process comprising the steps of (1) introducing a feed stream into an alkylation zone wherein said feed stream is comprised of cumene and propylene, and wherein said alkylation zone contains an alkylation catalyst; (2) allowing the cumene and propylene in the feed stream to react together to produce a first mixture of para-diisopropylbenzene and meta-diisopropylbenzene; (3) fractionally distilling the mixture of para-diisopropylbenzene and meta-diisopropylbenzene in a fractional distillation step to separate the meta-diisopropylbenzene from the para-diisopropylbenzene; (4) isomerizing the meta-diisopropylbenzene in the presence of a transalkylation catalyst to produce a second mixture of para-diisopropylbenzene and meta-diisopropylbenzene; (5) recycling the second mixture of para-diisopropylbenzene and meta-diisopropylbenzene recovered from the transalkylation step to the fractional distillation step; and (6) recovering the para-diisopropylbenzene that was separated from the meta-diisopropylbenzene by the fractional distillation step.

  本发明涉及一种仅利用双异丙基苯和丙烯作为原料合成对二异丙基苯的方法。该合成技术的优点在于消除了苯作为该过程中的原料。消除苯的有益之处在于简化了该过程，并消除了购买和储存苯以用于合成的需要。从合成中消除苯对于工业应用来说特别有价值，因为基于环境、安全和健康问题，苯的使用一直受到攻击。本发明揭示了一种从双异丙基苯和丙烯中生产对二异丙基苯的方法，该方法包括以下步骤：(1)将馈流引入烷基化区，其中该馈流由双异丙基苯和丙烯组成，该烷基化区含有烷基化催化剂；(2)使馈流中的双异丙基苯和丙烯相互反应，产生对二异丙基苯和间二异丙基苯的第一混合物；(3)在分馏步骤中分馏对二异丙基苯和间二异丙基苯的混合物，以将间二异丙基苯与对二异丙基苯分离；(4)在转移烷基化催化剂的存在下异构化间二异丙基苯，产生对二异丙基苯和间二异丙基苯的第二混合物；(5)回收从转移烷基化步骤中回收的对二异丙基苯和间二异丙基苯的第二混合物到分馏步骤；以及(6)回收通过分馏步骤与间二异丙基苯分离的对二异丙基苯。
• Meyer,H.; Bernhauer, Monatshefte fur Chemie, 1929, vol. 53/54, p. 728
  作者：Meyer,H.、Bernhauer

  DOI：——

  日期：——
• Hydrogen Fluoride as a Condensing Agent. XI. The Reaction of Alcohols and Ethers with Benzene¹
  作者：J. H. Simons、S. Archer

  DOI：10.1021/ja01863a508

  日期：1940.6

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