Occupational hepatotoxin - Secondary hepatotoxins: the potential for toxic effect in the occupational setting is based on cases of poisoning by human ingestion or animal experimentation.
来源:Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
TRIMETHYL 1,2,4-BENZENETRICARBOXYLATE WAS NOT MUTAGENIC IN SALMONELLA TYPHIMURIUM STRAINS TA100 OR TA98 IN THE PRESENCE OR ABSENCE OF S-9 LIVER ENZYMES.
Trimethyl 1,2,4-benzenetricarboxylate (CAS# 2459-10-1) was evaluated for acute oral toxicity. The test substance was administered by intragastric intubation to young adult ChR-CD male rats. Dosage levels and mortality data are as follows: 10,000 (0/10); 11,000 (4/10); 12,000 (4/10); and 14,000 mg/kg of body weight (8/10), with all deaths occurring 4-days after dosing. Clinical signs at 10,000 mg/kg and above included salivation, weakness, stained and wet perineal area, stained face, pallor, chromodacryorrhea, and moderate weight loss. The LD50 was determined to be 12,232 mg/kg b.w.
[EN] CONTINUOUS DEHYDROGENATION OF 1,4-CARBOXYLATE SUBSTITUTED CYCLOHEXENES [FR] DÉSHYDROGÉNATION EN CONTINU DE CYCLOHEXÈNES SUBSTITUÉS PAR 1,4-CARBOXYLATE
Synthesis, characterization and catalytic application of some novel PNP-Ni(II) complexes: Regio-selective [2+2+2] cycloaddition reaction of alkyne
作者：Masilamani Tamizmani、Chinnappan Sivasankar
DOI：10.1016/j.jorganchem.2017.02.039
日期：2017.9
We have also performed alkyne [2+2+2] cycloaddition reaction using Ni(II) complexes and observed high regioselectivity of the products. The observed selectivity is well correlating with the electronic feature of alkynes. The [2+2+2] cycloaddition of electron rich alkynes produced 1,3,5-substituted benzene derivatives as a major product whereas the electron deficient alkynes produced 1,2,4-substituted
Dearomatization−Bis-alkylation of Aromatic and Heteroaromatic Diesters Promoted by Me<sub>3</sub>SnLi via a Stanna−Brook Rearrangement
作者：Pablo Monje、Paula Graña、M. Rita Paleo、F. Javier Sardina
DOI：10.1021/ol053130r
日期：2006.3.2
Reaction of Me3SnLi with aromatic and heteroaromatic diesters proceeds through a fast stanna-Brook rearrangement that generates an stable bis-enolate which can be regioselectively alkylated and cyclized, in one step, to bicyclic compounds containing 6,5-, 6,6-, and 6,7-fused ring systems.
Identification and Quantification of Aerosol Polar Oxygenated Compounds Bearing Carboxylic or Hydroxyl Groups. 1. Method Development
作者：M. Jaoui、T. E. Kleindienst、M. Lewandowski、E. O. Edney
DOI：10.1021/ac049919h
日期：2004.8.1
In this study, a new analytical technique was developed for the identification and quantification of multifunctional compounds containing simultaneously at least one hydroxyl or one carboxylic group, or both. This technique is based on derivatizing first the carboxylic group(s) of the multifunctional compound using an alcohol (e.g., methanol, 1-butanol) in the presence of a relatively strong Lewis acid (BF3) as a catalyst. This esterification reaction quickly and quantitatively converts carboxylic acids to their ester forms. The second step is based on silylation of the ester compounds using bis(trimethylsilyl) trifluoroacetamide (BSTFA) as the derivatizing agent. For compounds bearing ketone groups in addition to carboxylic and hydroxyl groups, a third step was used based on PFBHA derivatization of the carbonyls. Different parameters including temperature, reaction time, and effect due to artifacts were optimized. A GC/MS in EI and in methane-CI mode was used for the analysis of these compounds. The new approach was tested on a number of multifunctional compounds. The interpretation of their EI (70 eV) and CI mass spectra shows that critical information is gained leading to unambiguous identification of unknown compounds. For example, when derivatized only with BF3−methanol, their mass spectra comprise primary ions at m/z M•+ + 1, M•+ + 29, and M•+ − 31 for compounds bearing only carboxylic groups and M•+ + 1, M•+ + 29, M•+ − 31, and M+. − 17 for those bearing hydroxyl and carboxylic groups. However, when a second derivatization (BSTFA) was used, compounds bearing hydroxyl and carboxylic groups simultaneously show, in addition to the ions observed before, ions at m/z M•+ + 73, M•+ − 15, M•+ − 59, M•+ − 75, M•+ − 89, and 73. To the best of our knowledge, this technique describes systematically for the first time a method for identifying multifunctional oxygenated compounds containing simultaneously one or more hydroxyl and carboxylic acid groups.
Pd and Ni complexes of a novel vinylidene β-diketimine ligand: Their application as catalysts in Heck coupling and alkyne trimerization
作者：Raghavendra Beesam、Dastagiri Reddy Nareddula
DOI：10.1002/aoc.3696
日期：2017.9
A β‐diketimine ligand with vinylidene substitution at γ‐carbon, CH2C(CH3CNAr)2 (Ar = 2,6‐diisopropylphenyl) (L2), was synthesized by treating β‐diketimine H2C(CH3CNAr)2 with n‐BuLi followed by paraformaldehyde. L2 formed the homobimetallic ether‐bridged β‐diketiminatecomplex [O(CH2‐β‐diketiminate)Pd(OAc)}2] (1) with (PdOAc)2. It also gave complexes [L2PdCl2] (2) and [L2NiBr2] (3) when treated with
