1,4-二碘-2-甲基丁烷 | 66688-32-2

• 分子结构分类: 有机化合物 - 有机卤素化合物 - 有机碘化物
• 中文名称: 1,4-二碘-2-甲基丁烷
• 英文名称: 1,4-diiodo-2-methylbutane
• 英文别名: 2-methyl-1,4-diiodobutane
• CAS: 66688-32-2
• 化学式: C₅H₁₀I₂
• 分子量: 323.943
• InChiKey: IKMBCKCVNIOJIN-UHFFFAOYSA-N

物化性质

• 熔点：
  9°C (estimate)
• 沸点：
  269.7°C (estimate)
• 密度：
  2.1611 (rough estimate)

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  7
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

反应信息

• 作为反应物：
  描述：

  1,4-二碘-2-甲基丁烷 在 二异丁基氢化铝 、 lithium diisopropyl amide 作用下， 以 正己烷 、 二氯甲烷 为溶剂， 反应 7.25h， 生成 cis-1-(trimethylsilyl)-3-methylcyclopentanemethanol
  参考文献：
  名称：

  Cleavage of carbon-carbon bonds with high stereochemical control. 7. Chiral .alpha.-silyl benzoylcycloalkanes undergo base-catalyzed cleavage with retention of configuration when not sterically congested

  摘要：

  DOI：

  10.1021/jo00267a032
• 作为产物：
  描述：

  1,4-二溴-2-甲基丁烷 在 sodium iodide 作用下， 以 丙酮 为溶剂， 以99%的产率得到1,4-二碘-2-甲基丁烷
  参考文献：
  名称：

  Cleavage of carbon-carbon bonds with high stereochemical control. 7. Chiral .alpha.-silyl benzoylcycloalkanes undergo base-catalyzed cleavage with retention of configuration when not sterically congested

  摘要：

  DOI：

  10.1021/jo00267a032

文献信息

• 一种屏蔽酚化合物、其制造方法及其作为抗氧 剂的应用
  申请人：中国石油化工股份有限公司

  公开号：CN105315183B

  公开（公告）日：2019-02-01

  本发明涉及一种如下式(I)所示的屏蔽酚化合物、其制造方法及其作为抗氧剂的应用，式(I)中各基团的定义同说明书。使用本发明的屏蔽酚化合物作为抗氧剂，可以制造出高温抗氧化性能优异的润滑油组合物。
• A HINDERED PHENOL COMPOUND, PREPARATION THEREOF AND USE THEREOF AS AN ANTIOXIDANT
  申请人：China Petroleum & Chemical Corporation

  公开号：EP2952505B1

  公开（公告）日：2018-05-23
• A Convenient Method for the Synthesis of Diiodo Compounds. Facile Cleavage of Cyclic Ethers by Phenyl Dichlorophosphate and Sodium Indide
  作者：Hsing-Jang Liu、Lisa M. Shewchuk、Montse Llinas-Brunet

  DOI：10.3987/r-1986-11-3043

  日期：——
• Inhibition of liver alcohol dehydrogenase and ethanol metabolism by 3-substituted thiolane 1-oxides
  作者：Vijay K. Chadha、Kevin G. Leidal、Bryce V. Plapp

  DOI：10.1021/jm00379a009

  日期：1985.1

  3-Substituted thiolane 1-oxides (methyl, n-butyl, n-hexyl, and phenyl) were prepared and tested as inhibitors of horse, monkey, and rat liver alcohol dehydrogenases and of ethanol metabolism in rats. These compounds inhibit alcohol oxidation in an uncompetitive manner with respect to ethanol as a varied substrate. Lengthening the alkyl substituent increased the inhibitory potency because of tighter binding in the hydrophobic substrate binding pocket of the alcohol dehydrogenases. Thus, the 3-hexyl derivative was the most potent inhibitor of the purified rat liver alcohol dehydrogenase, with a Kii value of 0.13 microM. The 3-butyl derivative was the best inhibitor of ethanol metabolism in rats, with a Kii value of 11 mumol/kg. The acute toxicity in mice of the butyl derivative was 1.4 mmol/kg. Since high concentrations of alcohol do not prevent the inhibitory effects of these compounds, they may be particularly useful for preventing poisoning by methanol or ethylene glycol.
• Synthesis and biological evaluation of 9-(5′,5′-difluoro-5′-phosphonopentyl)guanine derivatives for PNP-inhibitors
  作者：Sadao Hikishima、Machiko Isobe、Satoru Koyanagi、Shinji Soeda、Hiroshi Shimeno、Shiroshi Shibuya、Tsutomu Yokomatsu

  DOI：10.1016/j.bmc.2005.10.017

  日期：2006.3

  9-(5',5'-Difluoro-5'-phosphonopentyl)guanine (DFPP-G) and its hypoxanthine analogue (DFPP-H) were modified by introducing a methyl group to all possible positions of the linker connecting a purine and difluoromethylenephosphonic acid moiety to evaluate the effects of the methyl group on inhibition against purine nucleoside phosphorylase. The methyl group on the linker affected the inhibition in a positional-dependent manner. Inhibitory potency of alpha-methyl and beta-methyl -substituted analogues of DFPP-H increased by about 600- to 1000-fold upon converting to cyclopropane nucleotide analogue (+/-)-4. (c) 2005 Elsevier Ltd. All rights reserved.