正庚酸钠盐 | 10051-45-3

• 物质功能分类: 有机原料 - 羧酸类化合物及衍生物
• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 中文名称: 正庚酸钠盐
• 中文别名: 庚酸鈉；庚酸钠盐
• CAS: 10051-45-3
• 化学式: C7H14NaO2
• 分子量: 153.17
• InChiKey: IYPLHUBMNIVACI-UHFFFAOYSA-N

物化性质

• 熔点：
  350 °C
• 密度：
  1.204 g/cm3

计算性质

• 辛醇/水分配系数(LogP)：
  1.66
• 重原子数：
  10
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

安全信息

• 安全说明：
  S24/25
• 海关编码：
  2915900090
• 危险性防范说明：
  P261,P305+P351+P338
• 危险性描述：
  H302,H315,H319,H335

文献信息

• [EN] N-ALKYL PYRROLES AS HMG-COA REDUCTASE INHIBITORS<br/>[FR] PYRROLES DE N-ALKYL COMME INHIBITEURS DE L'HMG-COA-REDUCTASE
  申请人：WARNER LAMBERT CO

  公开号：WO2005056004A1

  公开（公告）日：2005-06-23

  HMGCo-A reductase inhibitor compounds useful as hypocholesterolemic and hypolipidemic compounds are provided. Also provided are pharmaceutical compositions of the compounds. Methods of making and methods of using the compounds are also provided. Formula (I).

  提供了作为降胆固醇和降脂化合物有用的HMGCo-A还原酶抑制剂化合物。还提供了这些化合物的药物组合物。还提供了制备这些化合物的方法和使用这些化合物的方法。公式（I）。
• [EN] AN IN-SITU PROCESS FOR THE PREPARATION OF HIGHLY PURE MONTELUKAST SODIUM<br/>[FR] PROCÉDÉ IN SITU POUR LA PRÉPARATION DE MONTÉLUKAST SODIQUE HAUTEMENT PUR
  申请人：MELODY HEALTHCARE PVT LTD

  公开号：WO2014118796A1

  公开（公告）日：2014-08-07

  The present invention disclosed herein is a cost effective, in-situ process for the preparation of montelukast or its pharmaceutically acceptable salts of formula (1) by reacting optically pure (S)-1-3-[2-(7-chloroquinolin-2-yl)ethylene]-phenyl}-3-[2-(1-hydroxy-1-methyl ethyl) phenyl]-propan-I-ol with methane sulfonyl chloride to afford mesylate derivative of formula (2) substantially free of impurities; followed by insitu condensing the same with disodium salt of mercapto-cyclopropyl acetic acid of formula (3) to afford montelukast free acid in good yield and purity, then converting the montelukast free acid into its substituted amine salt of formula (4). Further the montelukast substituted amine is converted into its pharmaceutically acceptable salt.

  本发明公开了一种成本效益高的原位制备montelukast或其药学上可接受的盐的方法，通过将光学纯的(S)-1-3-[2-(7-氯喹啉-2-基)乙烯]-苯基}-3-[2-(1-羟基-1-甲基乙基)苯基]-丙烷-1-醇与甲磺酰氯反应，得到几乎不含杂质的mesylate衍生物，其化学式为(2)；然后在原位与化学式为(3)的巯基环丙基乙酸二钠盐缩合，得到高收率和纯度的montelukast游离酸，然后将montelukast游离酸转化为其取代胺盐，化学式为(4)。进一步将montelukast取代胺转化为其药学上可接受的盐。
• POLYCARBONATE RESIN COMPOSITION
  申请人：Teijin Limited

  公开号：EP3135727A1

  公开（公告）日：2017-03-01

  A polycarbonate resin composition comprising a polycarbonate resin and 0.001 to 1 parts by weight of an N-R type (R represents an alkyl group) hindered amine-based optical stabilizer per 100 parts by weight of the polycarbonate resin, wherein the polycarbonate resin comprises 40 mol% or more of a recurring unit (A) represented by the following formula and satisfies the following formulas (i) to (v), and the resin composition has excellent heat resistance, a low water absorption coefficient and high transparency, and suppresses deterioration during long-term use: (i) a metal compound comprising a negative ion represented by the following formula (B) and a positive ion constituted by a metal is used as a polymerization catalyst in an amount of 1 × 10-9 to 1 × 10-5 molar equivalent relative to the total diol compounds used for polymerization; (ii) the specific viscosity measured with a methylene chloride solution at 20°C is 0.23 to 0.60; (iii) the glass transition temperature is 100°C to 160°C; (iv) the saturated water absorption coefficient is 2.5% or less; and (v) the relationship between the glass transition temperature (Tg°C) and the saturated water absorption coefficient (Wa%) satisfies the following formula (I): 2.5≤Tw value=Tg×0.04−Wa wherein R1 is an alkylene group, a cycloalkylene group, or an arylalkylene group which has 1 to 22 carbon atoms and may be linear or branched.

  一种聚碳酸酯树脂组合物，包括聚碳酸酯树脂和每 100 份聚碳酸酯树脂重量含 0.001 至 1 份 N-R 型(R 代表烷基)受阻胺基光学稳定剂，其中聚碳酸酯树脂包含 40 摩尔％或更多由下式表示的循环单元(A)，并满足以下公式(i)至(v)，且该树脂组合物具有优异的耐热性、低吸水系数和高透明度，并在长期使用过程中抑制劣化： (i) 使用由下式（B）表示的负离子和金属构成的正离子组成的金属化合物作为聚合催化剂，其用量相对于用于聚合的二元醇化合物总量为 1 × 10-9 至 1 × 10-5 摩尔当量； (ii) 在 20°C 時以二氯甲烷溶液測得的比黏度為 0.23 至 0.60； (iii) 玻璃化转变温度为 100°C 至 160°C (iv) 饱和吸水系数为 2.5%或更低；以及 (v) 玻璃化转变温度(Tg°C)与饱和吸水系数(Wa%)之间的关系满足下式(I)：2.5≤Tw 值=Tg×0.04-Wa 其中，R1 是烷基、环烷基或芳基烷基，具有 1 至 22 个碳原子，可以是直链或支链。
• BIO-ELECTRODE, METHOD FOR MANUFACTURING BIO-ELECTRODE, AND METHOD FOR MEASURING BIOLOGICAL SIGNAL
  申请人：Shin-Etsu Chemical Co., Ltd.

  公开号：EP3881766A1

  公开（公告）日：2021-09-22

  A bio-electrode includes an electro-conductive base material and a living body contact layer. The living body contact layer includes a water-free resin layer and a permeation layer on a surface side of the resin layer where a living body comes into contact. The permeation layer is permeated with water and a watersoluble salt selected from the group consisting of sodium salts, potassium salts, calcium salts, magnesium salts, and betaines. This aims to provide: a dry-type bio-electrode that enables quick signal collection after attachment to skin, the bio-electrode being excellent in electric conductivity and biocompatibility, light-weight, and manufacturable at low cost, and capable of preventing significant reduction in the electric conductivity even when wetted with water or dried; a method for manufacturing the bio-electrode; and a method for measuring a biological signal.

  生物电极包括导电基底材料和活体接触层。活体接触层包括无水树脂层和位于树脂层与活体接触表面一侧的渗透层。渗透层渗透有水和从钠盐、钾盐、钙盐、镁盐和甜菜碱组成的组中选出的水溶性盐。本发明旨在提供：一种干式生物电极，可在附着于皮肤后快速采集信号，该生物电极具有良好的导电性和生物相容性，重量轻，可低成本制造，即使被水浸湿或干燥，也能防止导电性显著降低；一种制造该生物电极的方法；以及一种测量生物信号的方法。
• BIO-ELECTRODE COMPOSITION, BIO-ELECTRODE, METHOD FOR MANUFACTURING BIO-ELECTRODE, POLYMER COMPOUND, AND COMPOSITE
  申请人：Shin-Etsu Chemical Co., Ltd.

  公开号：EP3984456A1

  公开（公告）日：2022-04-20

  A bio-electrode composition contains (A) a composite of an ionic polymer material and particles. The component (A) contains the particles bonding to the polymer containing a repeating unit having a structure selected from the group consisting of salts of ammonium, lithium, sodium, potassium, and silver formed with any of fluorosulfonic acid, fluorosulfonimide, and N-carbonyl-fluorosulfonamide. Thus, the present invention provides: a bio-electrode composition capable of forming a living body contact layer for a bio-electrode which is excellent in electric conductivity and biocompatibility, light-weight, and manufacturable at low cost, and which prevents significant reduction in the electric conductivity even when wetted with water or dried; a bio-electrode including a living body contact layer formed of the bio-electrode composition; and a method for manufacturing the bio-electrode.

  一种生物电极组合物包含（A）离子聚合物材料和颗粒的复合材料。组分（A）包含与聚合物粘合的颗粒，聚合物含有重复单元，该重复单元的结构选自由铵盐、锂盐、钠盐、钾盐和银盐组成的组，这些盐与氟磺酸、氟磺酰亚胺和 N-羰基-氟磺酰胺中的任意一种形成。因此，本发明提供了：一种能够为生物电极形成活体接触层的生物电极组合物，其导电性和生物相容性极佳，重量轻，可低成本制造，即使被水浸湿或干燥，也不会显著降低导电性；一种生物电极，包括由该生物电极组合物形成的活体接触层；以及一种制造该生物电极的方法。