1-羟基-3-癸酮 | 67633-95-8

• 物质功能分类: 有机原料 - 酮类化合物
• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 中文名称: 1-羟基-3-癸酮
• 英文名称: 1-hydroxydecan-3-one
• CAS: 67633-95-8
• 化学式: C₁₀H₂₀O₂
• 分子量: 172.268
• InChiKey: XDFCZUMLNOYOCH-UHFFFAOYSA-N

物化性质

• 沸点：
  269.6±13.0 °C(Predicted)
• 密度：
  0.915±0.06 g/cm3(Predicted)
• LogP：
  2.318 (est)
• 保留指数：
  1341

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  12
• 可旋转键数：
  8
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.9
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  反式-2-癸烯醇 在 叔丁基过氧化氢 、 silver hexafluoroantimonate 、 二氯[2-(4,5-二氢-2-噁唑基)喹啉]钯(II) 作用下， 以 二氯甲烷 、 水 为溶剂， 以32%的产率得到1-羟基-3-癸酮
  参考文献：
  名称：

  Wacker-Type Oxidation of Internal Alkenes using Pd(Quinox) and TBHP

  摘要：

  The Pd-catalyzed TBHP-mediated Wacker-type oxidation of internal alkenes is reported. The reaction uses 2(4,5-dihydro-2-oxazolyl)quinoline (Quinox) as ligand and TBHP(aq) as oxidant to deliver single ketone constitutional isomer products in a predictable fashion from electronically biased olefins. This methodology is showcased through its application on an advanced intermediate in the total synthesis of the antimalarial drug artemisinin.

  DOI：

  10.1021/jo302638v

文献信息

• Fragrance Compositions Comprising Ionic Liquids
  申请人：The Procter & Gamble Company

  公开号：US20170121633A1

  公开（公告）日：2017-05-04

  The present invention relates to a fragrance composition comprising ionic liquids for delayed evaporation of the perfume raw materials. The invention also relates to methods of use of the fragrance compositions for perfuming suitable substrates, particularly skin and hair.

  本发明涉及一种香精组合物，包括离子液体，用于延迟香水原料的挥发。该发明还涉及使用香精组合物来香味适合的基质的方法，特别是皮肤和头发。
• DRUG FOR INHIBITING LECTIN-LIKE OXIDIZED LDL RECEPTOR AND DRUG FOR PREVENTING ARTERIOSCLEROSIS
  申请人：National Cerebral and Cardiovascular Center

  公开号：EP2447257A1

  公开（公告）日：2012-05-02

  A compound having an excellent activity to inhibit a lectin-like oxidized LDL receptor has been identified. There are provided a drug for inhibiting a lectin-like oxidized LDL receptor characterized by including a trimeric or higher polymeric procyanidin as an active ingredient, which is useful in treating and preventing diseases, in particular, arteriosclerotic diseases, for which a lectin-like oxidized LDL receptor acts as an aggravating factor; the aforementioned drug for inhibiting a lectin-like oxidized LDL receptor, characterized in that the procyanidin is derived from a plant material selected from the group consisting of apples, grape seeds, peanut seed coats and pine barks; and a drug for preventing arteriosclerosis including a trimeric or higher polymeric procyanidins as an active ingredient, and characterized by having an activity to inhibit a lectin-like oxidized LDL receptor.

  现已发现一种化合物具有抑制凝集素样氧化低密度脂蛋白受体的优异活性。 提供了一种用于抑制凝集素样氧化低密度脂蛋白受体的药物，其特征在于包括三聚或更高聚合原花青素作为活性成分，该药物可用于治疗和预防凝集素样氧化低密度脂蛋白受体作为加重因素的疾病，特别是动脉硬化性疾病； 上述用于抑制凝集素样氧化低密度脂蛋白受体的药物，其特征在于原花青素来自选自苹果、葡萄籽、花生种皮和松树皮组成的植物材料组；以及 一种预防动脉硬化的药物，包括作为活性成分的三聚或更高聚合原花青素，其特征在于具有抑制凝集素样氧化低密度脂蛋白受体的活性。
• FRAGRANCE COMPOSITIONS AND USES THEREOF
  申请人：The Procter & Gamble Company

  公开号：EP3103431A1

  公开（公告）日：2016-12-14

  The present invention relates to a composition having improved or enhanced fidelity and/or longevity of the fragrance profile, comprising fragrance materials in a diamond construction and at least one substantially non-odorous fragrance modulator. The invention also relates to methods of use of the compositions for perfuming suitable substrates, including hard surfaces and body parts, particularly skin and hair.

  本发明涉及一种具有改进或增强的香味保真度和/或持久性的组合物，该组合物由钻石结构的香味材料和至少一种基本无臭的香味调节剂组成。本发明还涉及组合物的使用方法，用于对合适的基底（包括硬表面和身体部位，特别是皮肤和头发）进行加香。
• ABSORBENT ARTICLE COMPRISING FRAGRANCE COMPOSITION
  申请人：The Procter & Gamble Company

  公开号：EP3103523A1

  公开（公告）日：2016-12-14

  The present invention relates to a an absorbent article comprising a fragrance composition having improved or enhanced fidelity and/or longevity of the fragrance profile, comprising fragrance materials in a diamond construction and at least one substantially non-odorous fragrance modulator.

  本发明涉及一种由香味组合物组成的吸收制品，该香味组合物具有改进或增强的香味保真度和/或持久性，包括钻石结构的香味材料和至少一种基本无臭的香味调节剂。
• HYDROPHOBICALLY MODIFIED UREA ETHERS AS STRUCTURANTS FOR HYDROPHOBIC SYSTEMS
  申请人：Procter & Gamble International Operations SA

  公开号：EP3219743A1

  公开（公告）日：2017-09-20

  Consumer product compositions comprising hydrophobically modified urea ethers.

  包含疏水改性脲醚的消费品组合物。