2'-碘-2'-脱氧腺苷 | 68775-04-2

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘌呤核苷
• 中文名称: 2'-碘-2'-脱氧腺苷
• 英文名称: 2'-deoxy-2'-iodoadenosine
• 英文别名: 2'-I-dA；2'-iodo-2'-deoxy-adenosine；2'-Iod-2'-deoxy-adenosin；2'-Ioddesoxyadenosin；2'-Iodo-2'-deoxyadenosine；(2R,3R,4R,5R)-5-(6-aminopurin-9-yl)-2-(hydroxymethyl)-4-iodooxolan-3-ol
• CAS: 68775-04-2
• 化学式: C₁₀H₁₂IN₅O₃
• 分子量: 377.141
• InChiKey: VGKXEMCICHSUIU-QYYRPYCUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.1
• 重原子数：
  19
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  119
• 氢给体数：
  3
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  2'-碘-2'-脱氧腺苷 在 tri-n-butylammonium salt of imidodiphosphate 、 三甲氧基磷 、 三氯氧磷 作用下， 生成 2'-deoxy-2'-iodoadenosine 5'-(β,γ-imido)-triphosphate
  参考文献：
  名称：

  Synthesis of 2′-Iodo- and 2′-Bromo-ATP and GTP Analogues as Potential Phasing Tools for X-ray Crystallography

  摘要：

  DOI：

  10.1080/07328319908045600
• 作为产物：
  描述：

  阿糖腺苷 在 咪唑 、 4-二甲氨基吡啶 、 四丁基氟化铵 、 三乙胺 、 lithium iodide 作用下， 以 四氢呋喃 、 六甲基磷酰三胺 、 二氯甲烷 、 N,N-二甲基甲酰胺 为溶剂， 反应 26.16h， 生成 2'-碘-2'-脱氧腺苷
  参考文献：
  名称：

  Synthesis of 2′-Iodo- and 2′-Bromo-ATP and GTP Analogues as Potential Phasing Tools for X-ray Crystallography

  摘要：

  DOI：

  10.1080/07328319908045600

文献信息

• Sugar modified oligonucleotides
  申请人：ISIS Pharmaceuticals, Inc.

  公开号：US20030004325A1

  公开（公告）日：2003-01-02

  Compositions and methods are provided for the treatment and diagnosis of diseases amenable to modulation of the production of selected proteins. In accordance with preferred embodiments, oligonucleotides and oligonucleotide analogs are provided which are specifically hybridizable with a selected sequence of RNA or DNA wherein at least one of the 2′-deoxyfuranosyl moieties of the nucleoside unit is modified. Treatment of diseases caused by various viruses and other causative agents is provided.

  提供了用于治疗和诊断可通过调节特定蛋白质产生的疾病的组合物和方法。根据优选实施例，提供了可以与RNA或DNA的选定序列特异性杂交的寡核苷酸和寡核苷酸类似物，其中核苷酸单元的至少一个2'-脱氧呋喃糖苷基被修改。提供了治疗由各种病毒和其他致病因素引起的疾病的方法。
• 2' -modified oligonucleotides
  申请人：ISIS Pharmaceuticals, Inc.

  公开号：US20030187240A1

  公开（公告）日：2003-10-02

  Compositions and methods are provided for the treatment and diagnosis of diseases amenable to modulation of the production of selected proteins. In accordance with preferred embodiments, oligonucleotides and oligonucleotide analogs are provided which are specifically hybridizable with a selected sequence of RNA or DNA wherein at least one of the 2′-deoxyfuranosyl moieties of the nucleoside unit is modified. Treatment of diseases caused by various viruses and other causative agents is provided.

  提供了用于治疗和诊断可调节选择蛋白质生成的疾病的组合物和方法。根据优选实施例，提供了可以与RNA或DNA的选择序列特异性杂交的寡核苷酸和寡核苷酸类似物，其中核苷酸单元的至少一个2'-脱氧呋喃糖基团被修饰。提供了治疗由各种病毒和其他致病因子引起的疾病的方法。
• 2'-MODIFIED OLIGONUCLEOTIDES
  申请人：Cook Dan Phillip

  公开号：US20080032945A1

  公开（公告）日：2008-02-07

  Compositions and methods are provided for the treatment and diagnosis of diseases amenable to modulation of the production of selected proteins. In accordance with preferred embodiments, oligonucleotides and oligonucleotide analogs are provided which are specifically hybridizable with a selected sequence of RNA or DNA wherein at least one of the 2′-deoxyfuranosyl moieties of the nucleoside unit is modified. Treatment of diseases caused by various viruses and other causative agents is provided.

  本发明提供了用于治疗和诊断对调节所选蛋白质产生敏感的疾病的组合物和方法。根据优选实施例，提供了可以与RNA或DNA的所选序列特异性杂交的寡核苷酸和寡核苷酸类似物，其中核苷酸单元的至少一个2'-脱氧呋喃糖基团被修改。提供了治疗由各种病毒和其他致病因子引起的疾病的方法。
• 2'-Modified Oligonucleotides
  申请人：Cook Phillip Dan

  公开号：US20090198047A1

  公开（公告）日：2009-08-06

  Compositions and methods are provided for the treatment and diagnosis of diseases amenable to modulation of the production of selected proteins. In accordance with preferred embodiments, oligonucleotides and oligonucleotide analogs are provided which are specifically hybridizable with a selected sequence of RNA or DNA wherein at least one of the 2′-deoxyfuranosyl moieties of the nucleoside unit is modified. Treatment of diseases caused by various viruses and other causative agents is provided.

  本发明提供了用于治疗和诊断适于调节所选蛋白质产生的疾病的组合物和方法。根据优选实施例，提供了可以与RNA或DNA的选定序列特异性杂交的寡核苷酸和寡核苷酸类似物，其中核苷酸单元的至少一个2'-脱氧呋喃糖苷基团被修饰。提供了治疗由各种病毒和其他致病因子引起的疾病的方法。
• Compositions and methods for detecting and modulating rna activity and gene expression
  申请人：ISIS PHARMACEUTICALS, INC.

  公开号：EP1418179A2

  公开（公告）日：2004-05-12

  Compositions and methods for modulating the activity of RNA and DNA are disclosed. In accordance with preferred embodiments, antisense compositions are prepared comprising targeting and reactive portions. Reactive portions which act, alternatively, through phosphorodiester bond cleavage, through backbone sugar bond cleavage or through base modification are preferably employed. Groups which improve the pharmacodynamic and pharmacokinetic properties of the oligonucleotides are also useful in accordance with certain embodiments of this invention. Delivery of the reactive or non-reactive functionalities into the minor groove formed by the hybridization of the composition with the target RNA is also preferably accomplished. Therapeutics, diagnostics and research methods are also disclosed. Synthetic nucleosides and nucleoside fragments are also provided useful for elaboration of oligonucleotides and oligonucleotide analogs for such purposes.

  本文公开了调节 RNA 和 DNA 活性的组合物和方法。根据优选的实施方案，反义组合物由靶向部分和反应部分组成。反应部分最好通过磷酸二酯键裂解、骨架糖键裂解或碱基修饰起作用。根据本发明的某些实施方案，改善寡核苷酸药效学和药代动力学特性的基团也是有用的。最好还能将反应性或非反应性官能团输送到组合物与目标 RNA 杂交形成的次凹槽中。本发明还公开了治疗、诊断和研究方法。本发明还提供了合成核苷和核苷片段，可用于制备用于上述目的的寡核苷酸和寡核苷酸类似物。