氯二甲箭毒 | 33335-58-9

• 物质功能分类: 原料药 - 麻醉剂 - 骨骼肌松弛药
• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: 氯二甲箭毒
• 英文名称: Dimethyltubocurarinium chloride
• 英文别名: (1S,16R)-9,10,21,25-tetramethoxy-15,15,30,30-tetramethyl-7,23-dioxa-15,30-diazoniaheptacyclo[22.6.2.23,6.18,12.118,22.027,31.016,34]hexatriaconta-3(36),4,6(35),8(34),9,11,18(33),19,21,24,26,31-dodecaene;dichloride
• CAS: 33335-58-9
• 化学式: C40H48Cl2N2O6
• 分子量: 723.7
• InChiKey: IRPSJVWFSWAZSZ-OIUSMDOTSA-L

计算性质

• 辛醇/水分配系数(LogP)：
  1.46
• 重原子数：
  50
• 可旋转键数：
  4
• 环数：
  8.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  55.4
• 氢给体数：
  0
• 氢受体数：
  8

文献信息

• Microparticles With Modified Release of At Least One Active Principle and Oral Pharmaceutical Form Comprising Same
  申请人：Dargelas Frederic

  公开号：US20090220611A1

  公开（公告）日：2009-09-03

  The invention concerns microparticulate systems with modified release of oral active principle(s). The invention aims at providing a novel pharmaceutical with time-dependent and pH-dependent release mechanism, enabling: a) the latent period preceding the release of the active principle in the stomach; b) the pH triggering the release of the active principle in the intestine; c) the release speed of the active principle. This is achieved through the use of coated microparticles made from particles of active principle each coated with two coating films A and B. A comprises: film-forming (co)polymer (A1) insoluble in fluids of the gastrointestinal tract; ethylcellulose (co)polymer (A2) soluble in fluids of the gastrointestinal tract; plasticizing polyvinylpyrrolidone (A3); castor oil/optionally a surfactant and/or magnesium stearate lubricant (A4). B comprises a hydrophilic polymer (B1) bearing ionized groups with neutral pH (EUDRAGIT® L100-55) and a hydrophobic compound (B2) (LUBRITAB®). The invention also concerns medicines based on said microparticles.

  该发明涉及具有口服活性原理改性释放的微粒系统。该发明旨在提供一种具有时间依赖性和pH依赖性释放机制的新型药物，实现：a）在胃中释放活性原理之前的潜伏期；b）在肠道中触发释放活性原理的pH值；c）活性原理的释放速度。这是通过使用由活性原理颗粒制成的被包覆的微粒来实现的，每个微粒都涂有两层涂膜A和B。A包括：在胃肠道液体中不溶解的成膜（共）聚合物（A1）；在胃肠道液体中可溶解的乙基纤维素（共）聚合物（A2）；增塑剂聚乙烯吡咯烷酮（A3）；蓖麻油/可选的表面活性剂和/或硬脂酸镁润滑剂（A4）。B包括具有中性pH的离子化基团的亲水性聚合物（B1）（EUDRAGIT® L100-55）和疏水化合物（B2）（LUBRITAB®）。该发明还涉及基于这些微粒的药物。
• Diagnostic/therapeutic agents
  申请人：Klaveness Jo

  公开号：US20050002865A1

  公开（公告）日：2005-01-06

  Targetable diagnostic and/or therapeutically active agents, e.g. ultrasound contrast agents, comprising a suspension in an aqueous carrier liquid of a reporter comprising gas-containing or gas-generating material, said agent being capable of forming at least two types of binding pairs with a target.

  可定位的诊断和/或治疗活性剂，例如超声对比剂，包括悬浮在水载体液中的报告物，该报告物包含含气体或生成气体的材料，该剂能够与目标形成至少两种结合对。
• Unsaturated polyester resin system for cured in-place piping
  申请人：Interplastic Corporation

  公开号：US10131766B2

  公开（公告）日：2018-11-20

  A process to use an unsaturated polyester resin system comprising preparing a curable cumene-quat curing system. The cumene-quat curing system can comprise an unsaturated polyester resin, a peroxide initiator, a quaternary ammonium salt component, a 2,4-pentanedione component, and an inhibitor component. The peroxide initiator can comprise a cumene hydroperoxide component. The process can further comprise applying the curable cumene-quat curing system in a cured-in-place pipe rehabilitation process.

  一种使用不饱和聚酯树脂体系的工艺，包括制备可固化的积烯-夸特固化体系。积烯-夸特固化体系可包括不饱和聚酯树脂、过氧化物引发剂、季铵盐成分、2,4-戊二酮成分和抑制剂成分。过氧化物引发剂可包括过氧化氢积炭成分。该工艺还包括在就地固化管道修复工艺中应用可固化的积烯-夸特固化体系。
• MICROPARTICULES ENROBÉES A LIBERATION MODIFIEE D'AU MOINS UN PRINCIPE ACTIF ET FORME GALENIQUE ORALE LES COMPRENANT
  申请人：Flamel Ireland Limited

  公开号：EP1931320B1

  公开（公告）日：2022-06-15
• POLYMERS CONTAINING HEAT LABILE COMPONENTS ADSORBED ON POLYMERIC CARRIERS AND METHODS FOR THEIR PREPARATION
  申请人：Fosco, Frank, M., Jr.

  公开号：EP2731428A2

  公开（公告）日：2014-05-21