2,5-二氟-N-{2-氟-3-[2-(四氢吡喃-2-基)-2H-吡唑-3-基]苯基}-N-甲氧基甲基苯磺酰胺 | 1357587-47-3

分子结构分类

有机化合物 - 有机杂环化合物 - 唑类

中文名称

2,5-二氟-N-{2-氟-3-[2-(四氢吡喃-2-基)-2H-吡唑-3-基]苯基}-N-甲氧基甲基苯磺酰胺

中文别名

——

英文名称

2,5-difluoro-N-{2-fluoro-3-[2-(tetrahydropyran-2-yl)-2H-pyrazol-3-yl]phenyl}-N-methoxymethylbenzenesulfonamide

英文别名

2,5-difluoro-N-{2-fluoro-3-[2-(tetrahydro-pyran-2-yl)-2H-pyrazol-3-yl]-phenyl}-N-methoxymethyl-benzene-sulfonamide；2,5-difluoro-N-[2-fluoro-3-[2-(oxan-2-yl)pyrazol-3-yl]phenyl]-N-(methoxymethyl)benzenesulfonamide

2,5-二氟-N-{2-氟-3-[2-(四氢吡喃-2-基)-2H-吡唑-3-基]苯基}-N-甲氧基甲基苯磺酰胺化学式

CAS

1357587-47-3

化学式

C₂₂H₂₂F₃N₃O₄S

mdl

——

分子量

481.496

InChiKey

WKJYFJACKBQNRP-UHFFFAOYSA-N

BEILSTEIN

——

EINECS

——

物化性质

沸点：

615.0±65.0 °C(Predicted)
密度：

1.41±0.1 g/cm3(Predicted)

计算性质

辛醇/水分配系数(LogP)：

3.6
重原子数：

33
可旋转键数：

7
环数：

4.0
sp3杂化的碳原子比例：

0.32
拓扑面积：

82
氢给体数：

0
氢受体数：

9

上下游信息

上游原料

中文名称	英文名称	CAS号	化学式	分子量
——	N-(3-bromo-2-fluorophenyl)-2,5-difluoro-N-(methoxymethyl)benzenesulfonamide	1357587-46-2	C₁₄H₁₁BrF₃NO₃S	410.211

下游产品

中文名称	英文名称	CAS号	化学式	分子量
——	2,5-difluoro-N-[2-fluoro-3-(2H-pyrazol-3-yl)-phenyl]-N-methoxymethylbenzenesulfonamide	1357587-48-4	C₁₇H₁₄F₃N₃O₃S	397.378
——	2,5-difluoro-N-[2-fluoro-3-(1-piperidin-4-yl-4-pyridin-4-yl-1H-pyrazol-3-yl)phenyl]-N-methoxymethylbenzenesulfonamide	1357587-69-9	C₂₇H₂₆F₃N₅O₃S	557.596
——	N-[3-(4-bromo-1-isopropyl-3H-pyrazol-3-yl)-2-fluorophenyl]-2,5-difluoro-N-methoxymethylbenzenesulfonamide	1357587-50-8	C₂₀H₁₉BrF₃N₃O₃S	518.354
——	2,5-difluoro-N-{2-fluoro-3-[1-(1-methylpiperidin-4-yl)-4-pyridin-4-yl-1H-pyrazol-3-yl]phenyl}-N-methoxymethylbenzenesulfonamide	1357587-70-2	C₂₈H₂₈F₃N₅O₃S	571.623
——	N-{3-[1-(1-acetylpiperidin-4-yl)-4-pyridin-4-yl-1H-pyrazol-3-yl]-2-fluorophenyl}-2,5-difluoro-N-methoxymethylbenzenesulfonamide	1357587-71-3	C₂₉H₂₈F₃N₅O₄S	599.634
——	2,5-difluoro-N-[2-fluoro-3-(1-isopropyl-4-pyridin-4-yl-1H-pyrazol-3-yl)phenyl]-N-methoxymethylbenzenesulfonamide	1357587-59-7	C₂₅H₂₃F₃N₄O₃S	516.544
——	N-(3-{4-bromo-1-[2-(tetrahydropyran-2-yloxy)ethyl]-1H-pyrazol-3-yl}-2-fluorophenyl)-2,5-difluoro-N-methoxymethylbenzenesulfonamide	1357588-03-4	C₂₄H₂₅BrF₃N₃O₅S	604.445
——	2,5-difluoro-N-{2-fluoro-3-[1-(2-hydroxyethyl)-4-pyridin-4-yl-1H-pyrazol-3-yl]phenyl}-N-methoxymethylbenzenesulfonamide	1357588-05-6	C₂₄H₂₁F₃N₄O₄S	518.516
——	2,5-difluoro-N-(2-fluoro-3-{4-pyridin-4-yl-1-[2-(tetrahydropyran-2-yloxy)ethyl]-1H-pyrazol-3-yl}phenyl)-N-methoxymethylbenzenesulfonamide	1357588-04-5	C₂₉H₂₉F₃N₄O₅S	602.634
——	N-{3-[4-(2-tert-butylaminopyridin-4-yl)-1-piperidin-4-yl-1H-pyrazol-3-yl]-2-fluorophenyl}-2,5-difluoro-N-methoxymethylbenzenesulfonamide	1357587-98-4	C₃₁H₃₅F₃N₆O₃S	628.719
——	N-{3-[4-(2-cyanopyridin-4-yl)-1-(tetrahydropyran-4-yl)-1H-pyrazol-3-yl]-2-fluorophenyl}-2,5-difluoro-N-methoxymethylbenzenesulfonamide	1357588-18-1	C₂₈H₂₄F₃N₅O₄S	583.591
——	N-{3-[4-(2-tert-butylaminopyridin-4-yl)-1-(1-methylpiperidin-4-yl)-1H-pyrazol-3-yl]-2-fluorophenyl}-2,5-difluoro-N-methoxymethylbenzenesulfonamide	1357587-99-5	C₃₂H₃₇F₃N₆O₃S	642.745
——	N-{3-[1-(1-acetylpiperidin-4-yl)-4-(2-tert-butylaminopyridin-4-yl)-1H-pyrazol-3-yl]-2-fluorophenyl}-2,5-difluoro-N-methoxymethylbenzenesulfonamide	1357588-00-1	C₃₃H₃₇F₃N₆O₄S	670.756
——	4-(3-{3-[(2,5-difluorobenzenesulfonyl)methoxymethylamino]-2-fluorophenyl}-4-pyridin-4-ylpyrazol-1-yl)piperidine-1-carboxylic acid tert-butyl ester	1357587-67-7	C₃₂H₃₄F₃N₅O₅S	657.714
——	4-(4-bromo-3-{3-[(2,5-difluorobenzenesulfonyl)methoxymethylamino]-2-fluorophenyl}pyrazol-1-yl)piperidine-1-carboxylic acid tert-butyl ester	1357587-65-5	C₂₇H₃₀BrF₃N₄O₅S	659.524
——	4-[3-{3-[(2,5-difluorobenzenesulfonyl)methoxymethylamino]-2-fluorophenyl}-4-(1-oxypyridin-4-yl)pyrazol-1-yl]piperidine-1-carboxylic acid tert-butyl ester	1357587-96-2	C₃₂H₃₄F₃N₅O₆S	673.713
——	N-{3-[4-(2-cyanopyridin-4-yl)-1-(1-methylpiperidin-4-yl)-1H-pyrazol-3-yl]-2-fluorophenyl}-2,5-difluoro-N-methoxymethylbenzenesulfonamide	1357588-21-6	C₂₉H₂₇F₃N₆O₃S	596.633
——	N-[3-(4-bromo-1H-pyrazol-3-yl)-2-fluorophenyl]-2,5-difluoro-N-methoxymethylbenzenesulfonamide	1357587-49-5	C₁₇H₁₃BrF₃N₃O₃S	476.274
——	N-{3-[4-(2-aminopyrimidin-4-yl)-1-isopropyl-1H-pyrazol-3-yl]-2-fluorophenyl}-2,5-difluoro-N-methoxymethylbenzenesulfonamide	1357587-74-6	C₂₄H₂₃F₃N₆O₃S	532.546
——	4-(4-(2-tert-butylaminopyridin-4-yl)-3-{3-[(2,5-difluorobenzenesulfonyl)methoxymethylamino]-2-fluorophenyl}pyrazol-1-yl)piperidine-1-carboxylic acid tert-butyl ester	1357587-97-3	C₃₆H₄₃F₃N₆O₅S	728.836
——	4-(4-(2-cyanopyridin-4-yl)-3-{3-[(2,5-difluorobenzenesulfonyl)methoxymethylamino]-2-fluorophenyl}pyrazol-1-yl)piperidine-1-carboxylic acid tert-butyl ester	1357588-20-5	C₃₃H₃₃F₃N₆O₅S	682.723
——	2,5-difluoro-N-{2-fluoro-3-[1-(tetrahydropyran-4-yl)-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl )-1H-pyrazol-3-yl]phenyl}-N-methoxymethylbenzenesulfonamide	1357588-17-0	C₂₈H₃₃BF₃N₃O₆S	607.459
——	4-[3-{3-[(2,5-difluorobenzenesulfonyl)methoxymethylamino]-2-fluorophenyl}-4-(1H-pyrrolo[2,3-b]pyridin-4-yl)pyrazol-1-yl]piperidine-1-carboxylic acid tert-butyl ester	1357588-08-9	C₃₄H₃₅F₃N₆O₅S	696.75
——	2,5-difluoro-N-{2-fluoro-3-[1-isopropyl-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-1H-pyrazol-3-yl]phenyl}-N-methoxymethylbenzenesulfonamide	1357587-72-4	C₂₆H₃₁BF₃N₃O₅S	565.421
——	4-[3-{3-[(2,5-difluorobenzenesulfonyl)methoxymethylamino]-2-fluorophenyl}-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)pyrazol-1-yl]piperidine-1-carboxylic acid tert-butyl ester	1357588-07-8	C₃₃H₄₂BF₃N₄O₇S	706.591
——	methyl 4-[3-(3-{[(2,5-difluorophenyl)sulfonyl]amino}-2-fluorophenyl)-1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-yl]pyridine-2-carboxylate	1357587-39-3	C₂₇H₂₃F₃N₄O₅S	572.565
——	N-{3-[1-(1-acetylpiperidin-4-yl)-4-pyridin-4-yl-1H-pyrazol-3-yl]-2-fluorophenyl}-2,5-difluorobenzenesulfonamide	1357586-54-9	C₂₇H₂₄F₃N₅O₃S	555.58
——	4-[3-(3-{[(2,5-difluorophenyl)sulfonyl]amino}-2-fluorophenyl)-1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-yl]-N-methylpyridine-2-carboxamide	1357587-41-7	C₂₇H₂₄F₃N₅O₄S	571.58
——	4-[3-(3-{[(2,5-difluorophenyl)sulfonyl]amino}-2-fluorophenyl)-1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-yl]pyridine-2-carboxamide	1357587-38-2	C₂₆H₂₂F₃N₅O₄S	557.553
——	N-{3-[1-(1-acetylpiperidin-4-yl)-4-(2-aminopyridin-4-yl)-1H-pyrazol-3-yl]-2-fluorophenyl}-2,5-difluorobenzenesulfonamide	1357587-19-9	C₂₇H₂₅F₃N₆O₃S	570.595