4-amino-3-(6-methyl-1H-benzimidazol-2-yl)quinolin-2(1H)-one | 668423-42-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 4-amino-3-(6-methyl-1H-benzimidazol-2-yl)quinolin-2(1H)-one
• 英文别名: 4-Amino-3-(6-methylbenzimidazol-2-yl)hydroquinolin-2-one；4-amino-3-(6-methyl-1H-benzimidazol-2-yl)-1H-quinolin-2-one
• CAS: 668423-42-5
• 化学式: C₁₇H₁₄N₄O
• 分子量: 290.324
• InChiKey: BAWMPMUMXKTITQ-UHFFFAOYSA-N

物化性质

• 密度：
  1.370±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  22
• 可旋转键数：
  1
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  83.8
• 氢给体数：
  3
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  (5-甲基-1H-苯并咪唑-2-基)乙酸乙酯 、 2-氨基苯甲腈 在 lithium hexamethyldisilazane 作用下， 以 四氢呋喃 为溶剂， 反应 5.0h， 以50%的产率得到4-amino-3-(6-methyl-1H-benzimidazol-2-yl)quinolin-2(1H)-one
  参考文献：
  名称：

  Design, Structure−Activity Relationships and in Vivo Characterization of 4-Amino-3-benzimidazol-2-ylhydroquinolin-2-ones: A Novel Class of Receptor Tyrosine Kinase Inhibitors

  摘要：

  The inhibition of key receptor tyrosine kinases (RTKs) that are implicated in tumor vasculature formation and maintenance, as well as tumor progression and metastasis, has been a major focus in oncology research over the last several years. Many potent small molecule inhibitors of vascular endothelial growth factor receptor (VEGFR) and platelet-derived growth factor receptor (PDGFR) kinases have been evaluated. More recently, compounds that act through the complex inhibition of multiple kinase targets have been reported and may exhibit improved clinical efficacy. We report herein a series of potent, orally efficacious 4-amino3-benzimidazol-2-ylhydroquinolin-2-one analogues as inhibitors of VEGF, PDGF, and fibroblast growth factor (FGF) receptor tyrosine kinases. Compounds in this class, such as 5 (TK1258), are reversible ATP-competitive inhibitors of VEGFR-2, FGFR-1, and PDGFR beta with IC50 values <0.1 mu M. On the basis of its favorable in vitro and in vivo properties, compound 5 was selected for clinical evaluation and is currently in phase I clinical trials.

  DOI：

  10.1021/jm800790t

文献信息

• Modulation of inflammatory and metastatic processes
  申请人：Heise Carla

  公开号：US20050239825A1

  公开（公告）日：2005-10-27

  Methods of using compounds having Structure I or the salts or tautomers of the compounds in the treatment of disorders relating to cell adhesion and metastatic processes are presented herein.

  本文介绍了使用具有结构I的化合物或该化合物的盐或互变异构体来治疗与细胞黏附和转移过程相关的疾病的方法。
• Pharmaceutically acceptable salts of quinolinone compounds having improved pharmaceutical properties
  申请人：Cai Shaopei

  公开号：US20050209247A1

  公开（公告）日：2005-09-22

  A lacate salt of a compound of Formula I or a tautomer of the compound, wherein Formula I has the following structure and R 1 -R 9 and R 12 -R 14 are as defined herein

  一种化合物I的乳酸盐或其互变异构体，其中化合物I具有以下结构，R1-R9和R12-R14如此处所定义。
• PHARMACEUTICALLY ACCEPTABLE SALTS OF QUINOLINONE COMPOUNDS HAVING IMPROVED PHARMACEUTICAL PROPERTIES
  申请人：Cai Shaopei

  公开号：US20130018058A1

  公开（公告）日：2013-01-17

  A lacate salt of a compound of Formula I or a tautomer of the compound, wherein Formula I has the following structure and R 1 -R 9 and R 12 -R 14 are as defined herein

  一种化合物I的乳酸盐或其互变异构体，其中化合物I具有以下结构，R1-R9和R12-R14如此定义。
• Pharmaceutically Acceptable Salts of Quinolinone Compounds Having Improved Pharmaceutical Properties
  申请人：Cai Shaopei

  公开号：US20130338171A1

  公开（公告）日：2013-12-19

  A lacate salt of a compound of Formula I or a tautomer of the compound, wherein Formula I has the following structure and R 1 -R 9 and R 12 -R 14 are as defined herein

  一种Formula I化合物的乳酸盐或其互变异构体，其中Formula I具有以下结构，R1-R9和R12-R14如此定义。
• Benzimidazole quinolinones and uses thereof
  申请人：Novartis Vaccines and Diagnostics, Inc.

  公开号：EP2573079A2

  公开（公告）日：2013-03-27

  Methods of inhibiting various enzymes and treating various conditions are provided that include administering to a subject a compound of Structure I or IB, a pharmaceutically acceptable salt thereof, a tautomer thereof, or a pharmaceutically acceptable salt of the tautomer. Compounds having the Structure I and IB have the following structures and have the variables described herein. Such compounds may be used to prepare medicaments for use in inhibiting various enzymes and for use in treating conditions mediated by such enzymes.

  提供了抑制各种酶和治疗各种病症的方法，包括向受试者施用结构 I 或 IB 的化合物、其药学上可接受的盐、其同系物或同系物的药学上可接受的盐。具有结构 I 和 IB 的化合物具有以下结构，并具有本文所述的变量。此类化合物可用于制备抑制各种酶和治疗由此类酶介导的疾病的药物。