The present invention provides a large conductance calcium-activated K channel opener comprising a compound of the formula (I):
wherein R
1
and R
3
are each sulfonamide, carbamoyl, acyl, amino, and the like, m and n are each 0 to 2, R
2
and R
4
are each cyano, nitro, hydroxyl, an alkoxy, a halogen, or an alkyl, Ring A is benzene or a heterocyclic ring, Ring B is benzene, a heterocyclic ring, a cycloalkane etc, and Ring Q is pyrazole or isoxazole, or a pharmaceutically acceptable salt thereof as an active ingredient.
本发明提供了一种大导电性
钙激活K通道开放剂,其包括以下式子(I)的化合物:其中R1和R3各自为磺
酰胺基,
氨基甲酰基,酰基,
氨基等,m和n各自为0到2,R2和R4各自为
氰基,硝基,羟基,烷
氧基,卤素或烷基,环A为
苯环或杂环,环B为
苯环,杂环,
环己烷等,环Q为
吡唑环或
异噁唑环,或其药学上可接受的盐作为活性成分。