2-(5,6-二氢-4H-吡咯并[3,2,1-IJ]喹啉-1-基)-2-氧代乙酸甲酯 | 345264-02-0
中文名称
2-(5,6-二氢-4H-吡咯并[3,2,1-IJ]喹啉-1-基)-2-氧代乙酸甲酯
中文别名
——
英文名称
methyl 5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl-oxoacetate
英文别名
(5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)oxoacetic acid methyl ester；2-(5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)oxoacetic acid methyl ester；methyl 2-(5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-2-oxoacetate；methyl 2-(1-azatricyclo[6.3.1.04,12]dodeca-2,4,6,8(12)-tetraen-3-yl)-2-oxoacetate
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)
CAS
345264-02-0
化学式
C14H13NO3
mdl
——
分子量
243.262
InChiKey
ALUMSXHHLXAQTD-UHFFFAOYSA-N
BEILSTEIN
——
EINECS
——
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物化性质
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计算性质
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ADMET
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安全信息
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SDS
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制备方法与用途
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上下游信息
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文献信息
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表征谱图
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同类化合物
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相关功能分类
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相关结构分类
计算性质
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辛醇/水分配系数(LogP)：2.1
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重原子数：18
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可旋转键数：3
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环数：3.0
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sp3杂化的碳原子比例：0.29
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拓扑面积：48.3
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氢给体数：0
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氢受体数：3
安全信息
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储存条件：室温
上下游信息
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上游原料
中文名称 英文名称 CAS号 化学式 分子量 5,6-二氢-4H-吡咯并[3,2,1-ij]喹啉-1-羧酸 5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinoline-1-carboxylic acid 124730-56-9 C12H11NO2 201.225 5,6-二氢-4H-吡咯并[3,2,1-ij]喹啉-1-羧酸乙酯 5,6-dihydro-4H-pyrrolo [3,2,1-ij]quinoline-1-carboxylic acid ethyl ester 124730-53-6 C14H15NO2 229.279 5,6-二氢-4H-吡咯并[3,2,1-ij]喹啉 5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinoline 5840-01-7 C11H11N 157.215 -
下游产品
中文名称 英文名称 CAS号 化学式 分子量 —— 5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl(oxo)acetic acid 1122597-96-9 C13H11NO3 229.235 —— (5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)oxoacetamide 345264-44-0 C13H12N2O2 228.25 —— (2,3-dihydro-1H-pyrrolo[3,2,1-ij]quinolin-6-yl)acetamide 345264-43-9 C13H14N2O 214.267 —— (3S,4S)-3-(1H-indol-3-yl)-4-(6-oxo-5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)pyrrolidine-2,5-dione 1383937-56-1 C23H17N3O3 383.406 —— (3R,4R)-3-(1H-indol-3-yl)-4-(6-oxo-5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)pyrrolidine-2,5-dione 1383937-55-0 C23H17N3O3 383.406 (3R,4R)-3-(5,6-二氢-4H-吡咯并[3,2,1-IJ]喹啉-1-基)-4-(1H-吲哚-3-基)吡咯烷-2,5-二酮 Tivantinib 905854-02-6 C23H19N3O2 369.423 (3S,4S)-3-(5,6-二氢-4H-吡咯并[3,2,1-ij]喹啉)-4-(1H-吲哚)-2,5-吡咯烷二酮 (±)-trans-3-(5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-4-(1H-indol-3-yl)pyrrolidine-2,5-dione 905854-03-7 C23H19N3O2 369.423 —— 3(S),4(R)-3-(5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-4-(1H-indol-3-yl)pyrrolidine-2,5-dione —— C23H19N3O2 369.423 —— (3R,4R)-3-(5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-4-(6-hydroxy-1H-indol-3-yl)pyrrolidine-2,5-dione 1383937-44-7 C23H19N3O3 385.422 —— (rac)-trans-3-(5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-4-(6-hydroxy-1H-indol-3-yl)pyrrolidine-2,5-dione 1383937-43-6 C23H19N3O3 385.422 3-(5,6-二氢-4H-吡咯并[3,2,1-IJ]喹啉-1-基)-4-(1H-吲哚-3-基)-1H 3-(5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dion 345261-20-3 C23H17N3O2 367.407 —— 3-[4-(5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-2,5-dioxo-2,5-dihydro-1H-pyrrol-3-yl]-1H-indole-6-carboxylic acid methyl ester 345263-89-0 C25H19N3O4 425.444 —— 3-[4-(5,6-Dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-2,5-dioxo-2,5-dihydro-1H-pyrrol-3-yl]-1H-indole-5-carboxylic acid methyl ester 345265-22-7 C25H19N3O4 425.444 —— (±)-trans-3-(5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-1-hydroxymethyl-4-(1H-indol-3-yl)pyrrolidine-2,5-dione —— C24H21N3O3 399.449 —— (3R,4R)-3-[(R)-6-hydroxy-5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl]-4-(1H-indol-3-yl)pyrrolidine-2,5-dione 1383937-52-7 C23H19N3O3 385.422 —— (3S,4S)-3-((R)-6-hydroxy-5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-4-(1H-indol-3-yl)pyrrolidine-2,5-dione 1383937-53-8 C23H19N3O3 385.422 —— (3S,4S)-3-((S)-6-hydroxy-5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-4-(1H-indol-3-yl)pyrrolidine-2,5-dione 1383937-54-9 C23H19N3O3 385.422 —— 3-(5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-4-(6-bromo-1H-indol-3-yl)pyrrole-2,5-dione 345263-85-6 C23H16BrN3O2 446.303 —— 3-(5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-4-(5-bromo-1H-indol-3-yl)pyrrole-2,5-dione 345265-19-2 C23H16BrN3O2 446.303 —— 3-(5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-4-(6-chloro-1H-indol-3-yl)pyrrole-2,5-dione 345261-25-8 C23H16ClN3O2 401.852 —— 3-(5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-4-(6-fluoro-1H-indol-3-yl)pyrrole-2,5-dione 345263-87-8 C23H16FN3O2 385.397 —— 3-(5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-4-(6-trifluoromethyl-1H-indol-3-yl)pyrrole-2,5-dione 345262-73-9 C24H16F3N3O2 435.405 —— (±)-trans-2-dimethylaminoacetic acid-3-(5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-4-(1H-indol-3-yl)-2,5-dioxopyrrolidin-1-ylmethyl ester —— C28H28N4O4 484.555 —— 3-(5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-4-(6-(pyridin-3-yl)-1H-indol-3-yl)pyrrole-2,5-dione 345261-57-6 C28H20N4O2 444.492 —— 3-(5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-4-(6-(pyridin-4-yl)-1H-indol-3-yl)pyrrole-2,5-dione 345261-58-7 C28H20N4O2 444.492 —— 3-(5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-4-(3-methoxyphenyl)pyrrole-2,5-dione 905854-06-0 C22H18N2O3 358.397 —— 3-(5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-4-(5,6-difluoro-1H-indol-3-yl)pyrrole-2,5-dione 345261-40-7 C23H15F2N3O2 403.388 —— 3-(5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-4-(4-fluoro-1H-indol-3-yl)pyrrole-2,5-dione 345261-22-5 C23H16FN3O2 385.397 —— 3-(5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-4-(1H-indol-3-yl)-5-thioxo-1,5-dihydro-pyrrol-2-one 1094610-03-3 C23H17N3OS 383.473 —— 3-(5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-4-(2-chloro-4-fluorophenyl)pyrrole-2,5-dione 905854-16-2 C21H14ClFN2O2 380.806 —— phosphoric acid dibenzyl ester trans-3-(5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-4-(1H-indol-3-yl)-2,5-dioxo-pyrrolidin-1-ylmethyl ester —— C38H34N3O6P 659.678 - 1
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反应信息
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作为反应物：描述：2-(5,6-二氢-4H-吡咯并[3,2,1-IJ]喹啉-1-基)-2-氧代乙酸甲酯 在 20 % Pd(OH)2/C 盐酸 、 potassium tert-butylate 、 氢气 作用下， 以 四氢呋喃 、 3-甲基四氢呋喃 、 醋酸异丙酯 、 水 、 乙腈 为溶剂， 20.0~55.0 ℃ 、551.59 kPa 条件下， 反应 3.5h， 生成 (3R,4R)-3-(5,6-二氢-4H-吡咯并[3,2,1-IJ]喹啉-1-基)-4-(1H-吲哚-3-基)吡咯烷-2,5-二酮参考文献：名称：Purified Pyrroloquinolinyl-Pyrrolidine-2,5-Dione Compositions And Methods For Preparing And Using Same摘要：本发明涉及(-)-trans-3-(5,6-二氢-4H-吡咯[3,2,1-ij]喹啉-1-基)-4-(1H-吲哚-3-基)吡咯烷-2,5-二酮的形式1和形式2晶型。本发明还涉及手性纯度大于99%的(-)-trans-3-(5,6-二氢-4H-吡咯[3,2,1-ij]喹啉-1-基)-4-(1H-吲哚-3-基)吡咯烷-2,5-二酮化合物，以及制备这些化合物的方法。本发明还涉及包含这些(-)-trans-3-(5,6-二氢-4H-吡咯[3,2,1-ij]喹啉-1-基)-4-(1H-吲哚-3-基)吡咯烷-2,5-二酮化合物的药物组合物。本发明提供了通过向需要的受体施用含有手性纯度大于99%的(-)-trans-3-(5,6-二氢-4H-吡咯[3,2,1-ij]喹啉-1-基)-4-(1H-吲哚-3-基)吡咯烷-2,5-二酮或(-)-trans-3-(5,6-二氢-4H-吡咯[3,2,1-ij]喹啉-1-基)-4-(1H-吲哚-3-基)吡咯烷-2,5-二酮的形式1和形式2晶型的组合物的治疗细胞增殖紊乱，如癌症的方法。公开号：US20110160242A1
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作为产物：描述：5,6-二氢-4H-吡咯并[3,2,1-ij]喹啉-1-羧酸 在 copper chromite 作用下， 以