Synthesis, cytotoxic and antioxidant activities of new n-substituted 3-(benzimidazol-2-yl)-chromones containing 2,6-di-tert-butylphenol fragment
作者:Stanislav S. Shatokhin、Vladislav A. Tuskaev、Svetlana Ch. Gagieva、Alina A. Markova、Dmitry I. Pozdnyakov、Elizaveta K. Melnikova、Boris M. Bulychev、Eduard T. Oganesyan
DOI:10.1016/j.molstruc.2021.131683
日期:2022.2
3-formylchromones and 4-((2-aminophenyl)imino)-2,6-di-tert-butylcyclohexa-2,5-dienone gave a series of N-substituted benzimidazole derivatives, characterized by 1H and 13C NMR spectroscopy, mass spectrometry and elemental analysis. The molecular structures of compounds 1 and 4 were determined by single crystal X-ray diffraction studies. Compounds 1-8 exhibit cytotoxic activity against human colon cancer cells HCT116
Synthesis and crystal structure of 5-(3,5-di-tert-butyl-4-hydroxyphenyl)-1,2,3,5-tetrahydrophenazine
作者:L. Yu. Ukhin、K. Yu. Suponitskii、L. V. Belousova、T. N. Gribanova
DOI:10.1007/s11172-009-0119-y
日期:2009.5
5-(3,5-Di-tert-butyl-4-hydroxyphenyl)-1,2,3,5-tetrahydrophenazine was synthesized by the reaction of 2,6-di-tert-butyl-1,4-benzoquinone-4-(o-aminophenyl)imine with cyclohexanone. The structure of the reaction product was established by X-ray diffraction.
sensitive to the reaction conditions (type of solvent, ratio of reactants, and duration of the reaction) gives rise to various derivatives of a new condensed 10H-quinoxalino[3,2,1-kl]phenoxazin-10-one heteropentacyclic system. The reaction of 1 with N-phenyl-o-phenylenediamine results in the formation of three phenazine-like compounds and, unexpectedly, a derivative of a new spiro[1,3]dioxole-2,2′-fu