1-tert-butyl 5-ethyl 4-p-methoxyphenyl-2-methyl-6-phenyl-1,6-dihydropyrimidine-1,5-dicarboxylate | 1337541-33-9

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 肉桂酸及其衍生物
• 英文名称: 1-tert-butyl 5-ethyl 4-p-methoxyphenyl-2-methyl-6-phenyl-1,6-dihydropyrimidine-1,5-dicarboxylate
• 英文别名: 3-O-tert-butyl 5-O-ethyl 6-(4-methoxyphenyl)-2-methyl-4-phenyl-4H-pyrimidine-3,5-dicarboxylate
• CAS: 1337541-33-9
• 化学式: C₂₆H₃₀N₂O₅
• 分子量: 450.535
• InChiKey: KOBQIQIVOZGGHS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  33
• 可旋转键数：
  8
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  77.4
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  1-tert-butyl 5-ethyl 4-p-methoxyphenyl-2-methyl-6-phenyl-1,6-dihydropyrimidine-1,5-dicarboxylate 在 三氟乙酸 作用下， 以 二氯甲烷 为溶剂， 反应 1.0h， 以86%的产率得到5-ethyl 2-methyl-4-(4-methoxy)phenyl-6-phenyl-1,6-dihydropyrimidine-1,5-dicarboxylate
  参考文献：
  名称：

  Synthesis and Substitution Reactions of 4(6)-Chlorodihydropyrimidines

  摘要：

  Chlorination of the corresponding ketones with phenylphosphonic dichloride (PhPOCl2) provided ethyl 6(4)-chloro-2-methyl-4(6)-phenyl-1,4(6)dihydropyrimidine-5-carboxylate in good yield. The cross-coupling reactions of organoboronic acids or triethylborane with 1-tert-butyl 5-ethyl 4-chloro-2-methyl-6-phenyl-1,6-dihydropyrimidine-1,5-dicarboxylate synthesized by regiospecific alkoxycarbonylation of the chlorinated dihydropyrimidine afforded 1,4(3,4)-dihydropyrimidines having a variety of functional groups at position-6(4) in good to excellent yields.

  DOI：

  10.3987/com-11-12244
• 作为产物：
  描述：

  亚苯甲基丙二酸二乙酯 在 苯膦酰二氯 、 bis-triphenylphosphine-palladium(II) chloride 、 sodium ethanolate 、 sodium hydride 、 caesium carbonate 作用下， 以 乙醇 、 N,N-二甲基乙酰胺 、 N,N-二甲基甲酰胺 、 mineral oil 为溶剂， 反应 10.0h， 生成 1-tert-butyl 5-ethyl 4-p-methoxyphenyl-2-methyl-6-phenyl-1,6-dihydropyrimidine-1,5-dicarboxylate
  参考文献：
  名称：

  Synthesis and Substitution Reactions of 4(6)-Chlorodihydropyrimidines

  摘要：

  Chlorination of the corresponding ketones with phenylphosphonic dichloride (PhPOCl2) provided ethyl 6(4)-chloro-2-methyl-4(6)-phenyl-1,4(6)dihydropyrimidine-5-carboxylate in good yield. The cross-coupling reactions of organoboronic acids or triethylborane with 1-tert-butyl 5-ethyl 4-chloro-2-methyl-6-phenyl-1,6-dihydropyrimidine-1,5-dicarboxylate synthesized by regiospecific alkoxycarbonylation of the chlorinated dihydropyrimidine afforded 1,4(3,4)-dihydropyrimidines having a variety of functional groups at position-6(4) in good to excellent yields.

  DOI：

  10.3987/com-11-12244

文献信息

• Synthesis and Substitution Reactions of 4(6)-Chlorodihydropyrimidines
  作者：Hidetsura Cho、Yoshizumi Yasui、Satoshi Kobayashi、Masahiko Yamaguchi、Eunsang Kwon、Mieko Arisawa

  DOI：10.3987/com-11-12244

  日期：——

  Chlorination of the corresponding ketones with phenylphosphonic dichloride (PhPOCl2) provided ethyl 6(4)-chloro-2-methyl-4(6)-phenyl-1,4(6)dihydropyrimidine-5-carboxylate in good yield. The cross-coupling reactions of organoboronic acids or triethylborane with 1-tert-butyl 5-ethyl 4-chloro-2-methyl-6-phenyl-1,6-dihydropyrimidine-1,5-dicarboxylate synthesized by regiospecific alkoxycarbonylation of the chlorinated dihydropyrimidine afforded 1,4(3,4)-dihydropyrimidines having a variety of functional groups at position-6(4) in good to excellent yields.