毒理性
哺乳期使用总结：由于母乳中曲普坦（sumatriptan）含量较低，婴儿摄入的量很小。此外，它的口服生物利用度较差，进一步减少了婴儿对药物的暴露。一些作者建议，在单次皮下注射后8小时内暂停哺乳，几乎可以完全消除婴儿对药物的暴露。制造商建议在服用剂量后12小时内暂停哺乳。在极端情况下，例如早产儿的母亲，暂停哺乳可能有所帮助，但曲普坦不会对大多数哺乳婴儿产生任何不良影响。有一份未经证实的轶事报告称，单次注射曲普坦后哺乳停止。
对哺乳婴儿的影响：一位作者报告了与制造商的通信，制造商表示，在哺乳期间使用曲普坦（剂量和给药途径未指明）的3名妇女中，没有人报告对婴儿产生不良影响。
对泌乳和母乳的影响：一位作者报告了与制造商的通信，制造商表示，一名妇女在哺乳期间使用单次注射曲普坦（剂量未指明）后，出现了泌乳停止的情况。
◉ Summary of Use during Lactation:Because of the low levels of sumatriptan in breastmilk, amounts ingested by the infant are small. It also has poor oral bioavailability, further decreasing infant exposure to the drug. Some authors have suggested that withholding breastfeeding for 8 hours after a single subcutaneous injection would virtually eliminate infant exposure to the drug. The manufacturer recommends withholding breastfeeding for 12 hours after a dose. Withholding breastfeeding might be helpful in extreme cases, such as in the mother of a preterm infant, but sumatriptan would not be expected to cause any adverse effects in most breastfed infants. One anecdotal report of lactation ceasing after a single injection of sumatriptan has not been verified.
◉ Effects in Breastfed Infants:One author reported correspondence with the drug's manufacturer stating that of 3 women known to the manufacturer who used sumatriptan (dose and route unspecified) during breastfeeding none reported adverse effects on the infants.
◉ Effects on Lactation and Breastmilk:One author reported correspondence with the drug's manufacturer stating that 1 woman who used a single injection of sumatriptan (dose unspecified) during breastfeeding had a cessation of lactation.
来源:Drugs and Lactation Database (LactMed)
