7-methyl-7-carboxynorbornane | 69855-35-2

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: 7-methyl-7-carboxynorbornane
• 英文别名: 7-Methyl-bicyclo<1.2.2>heptan-carbonsaeure-(7)；7-Methylbicyclo<2.2.1>heptan-7-carbonsaeure；7-Methylbicyclo[2.2.1]heptan-7-carbonsaeure；7-Methylbicyclo[2.2.1]heptane-7-carboxylic acid
• CAS: 69855-35-2
• 化学式: C₉H₁₄O₂
• 分子量: 154.209
• InChiKey: QPICTPTYXYWKSP-UHFFFAOYSA-N

物化性质

• 沸点：
  257.6±8.0 °C(Predicted)
• 密度：
  1.134±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.89
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  7-methyl-7-carboxynorbornane 在 草酰氯 、 N,N-二甲基甲酰胺 作用下， 以 四氢呋喃 、 二氯甲烷 为溶剂， 生成 (4-Fluorophenyl)-(7-methyl-7-bicyclo[2.2.1]heptanyl)methanone
  参考文献：
  名称：

  通过结晶诱导的固定在手性构象中的非对称合成的非手性分子的预组织。

  摘要：

  DOI：

  10.1002/anie.200351609
• 作为产物：
  描述：

  7a-methyl-hexahydro-3,7-cyclo-cyclopenta[c]pyran-1-one 在 sodium 、 一水合肼 作用下， 以 二乙二醇 为溶剂， 反应 2.0h， 生成 7-methyl-7-carboxynorbornane
  参考文献：
  名称：

  Structures of the .gamma.-lactones from the acid-catalyzed cyclization of exo- and endo-2-methylnorbornene-2-carboxylic acid

  摘要：

  DOI：

  10.1021/jo01327a037

文献信息

• [EN] BICYCLIC INDOLYL DERIVATIVES AND METHODS OF THEIR USE AS SEROTONERGIC AGENTS<br/>[FR] DERIVES D'INDOLYLE BICYCLIQUES, ET PROCEDES RELATIFS A LEUR UTILISATION COMME AGENTS SEROTONERGIQUES
  申请人：WYETH CORP

  公开号：WO2004111035A1

  公开（公告）日：2004-12-23

  Bicyclic indolyl derivatives and compositions containing such compounds are disclosed. Methods of using the bicyclic indolyl derivatives and compositions containing such composition as serotonergic agents, such as in the treatment of depression and anxiety, are also disclosed. In addition, processes for the preparation of bicyclic indolyl derivatives are disclosed.

  本文披露了双环吲哚衍生物及含有这种化合物的组合物。还披露了使用双环吲哚衍生物和含有这种组合物作为5-羟色胺能药物的方法，例如用于治疗抑郁症和焦虑症。此外，还披露了制备双环吲哚衍生物的过程。
• Bicyclic indolyl derivatives and methods for their use as serotonergic agents
  申请人：Kelly G. Michael

  公开号：US20050124630A1

  公开（公告）日：2005-06-09

  Bicyclic indolyl derivatives and compositions containing such compounds are disclosed. Methods of using the bicyclic indolyl derivatives and compositions containing such composition as serotonergic agents, such as in the treatment of depression and anxiety, are also disclosed. In addition, processes for the preparation of bicyclic indolyl derivatives are disclosed.

  本发明公开了双环吲哚衍生物和含有这些化合物的组合物。还公开了使用双环吲哚衍生物和含有这种组合物作为血清素能药物的方法，例如用于治疗抑郁症和焦虑症。此外，还公开了制备双环吲哚衍生物的方法。
• 7H-dibenzo[b,g][1,5]dioxocin-5-one derivatives and use thereof
  申请人：Bischoff Hilmar

  公开号：US20060247303A1

  公开（公告）日：2006-11-02

  The present invention relates to substituted 7H-dibenzo[b,g][1,5]dioxocin-5-one-derivatives, to processes for their preparation and to their use in medicaments, in particular as inhibitors of the cholesterol ester transfer protein (CETP) for the treatment and/or prevention of cardiovascular disorders, in particular hypolipoproteinaemia, dyslipidaemias, hypertriglyceridaemias, hyperlipidaemias and arteriosclerosis.

  本发明涉及取代的7H-二苯并[b，g][1,5]二氧杂环戊烷-5-酮衍生物，其制备过程以及它们在药物中的应用，特别是作为胆固醇酯转移蛋白（CETP）的抑制剂，用于治疗和/或预防心血管疾病，特别是低脂蛋白血症，脂质代谢异常，高三酰甘油血症，高脂血症和动脉硬化。
• Bicyclic Indolyl Derivatives and Methods for Their Use as Serotonergic Agents
  申请人：Kelly Gerard Micahel

  公开号：US20070135445A1

  公开（公告）日：2007-06-14

  Bicyclic indolyl derivatives and compositions containing such compounds are disclosed. Methods of using the bicyclic indolyl derivatives and compositions containing such composition as serotonergic agents, such as in the treatment of depression and anxiety, are also disclosed. In addition, processes for the preparation of bicyclic indolyl derivatives are disclosed.

  本发明揭示了双环吲哚衍生物及含有这种化合物的组合物。本发明还揭示了使用双环吲哚衍生物和含有这种组合物作为5-羟色胺能药物的方法，例如在治疗抑郁和焦虑方面。此外，本发明还揭示了制备双环吲哚衍生物的方法。
• 7H-DIBENZO[B,G][1,5]DIOXOCIN-5-ON-DERIVATE UND IHRE VERWENDUNG
  申请人：Bayer HealthCare AG

  公开号：EP1560630A2

  公开（公告）日：2005-08-10