1-(biphenyl-4-yl)-2,2-difluoro-1-(4-methylphenyl)ethene | 1456808-64-2

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: 1-(biphenyl-4-yl)-2,2-difluoro-1-(4-methylphenyl)ethene
• 英文别名: 1-[2,2-Difluoro-1-(4-methylphenyl)ethenyl]-4-phenylbenzene；1-[2,2-difluoro-1-(4-methylphenyl)ethenyl]-4-phenylbenzene
• CAS: 1456808-64-2
• 化学式: C₂₁H₁₆F₂
• 分子量: 306.355
• InChiKey: GBKDZIHQNOOJGV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.4
• 重原子数：
  23
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  4-联苯硼酸 在 tris(dibenzylideneacetone)dipalladium(0) chloroform complex 、 三苯基膦 、 cesium fluoride 、 双二苯基膦甲烷 作用下， 以 1,4-二氧六环 、 水 为溶剂， 反应 15.0h， 生成 1-(biphenyl-4-yl)-2,2-difluoro-1-(4-methylphenyl)ethene
  参考文献：
  名称：

  Facile synthesis of unsymmetrical 1,1-diaryl-2,2-difluoroethenes via stepwise coupling of 1,1-dibromo-2,2-difluoroethenes

  摘要：

  Unsymmetrical 1,1-diaryl-2,2-difluoroethenes were synthesized from 1,1-dibromo-2,2-difluoroethene, which is commercially available, via the Suzuki-Miyaura coupling in a stepwise fashion. Suitable ligands for each coupling process were used to achieve selective synthesis of these diaryldifluoroethenes. (C) 2013 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.jfluchem.2013.06.010

文献信息

• Facile synthesis of unsymmetrical 1,1-diaryl-2,2-difluoroethenes via stepwise coupling of 1,1-dibromo-2,2-difluoroethenes
  作者：Takeshi Fujita、Naoto Suzuki、Tomohiro Ichitsuka、Junji Ichikawa

  DOI：10.1016/j.jfluchem.2013.06.010

  日期：2013.11

  Unsymmetrical 1,1-diaryl-2,2-difluoroethenes were synthesized from 1,1-dibromo-2,2-difluoroethene, which is commercially available, via the Suzuki-Miyaura coupling in a stepwise fashion. Suitable ligands for each coupling process were used to achieve selective synthesis of these diaryldifluoroethenes. (C) 2013 Elsevier B.V. All rights reserved.