申请人:Roussel Uclaf
公开号:US05064861A1
公开(公告)日:1991-11-12
A compound selected from the group consisting of a compound of the formula ##STR1## wherein R.sub.1 is selected from the group consisting of Ar-O- and aryl, polyaryl and condensed polyaryl unsubstituted or substituted and heterocycle unsubstituted or substituted, Ar is aryl of 6 to 14 carbon atoms unsubstituted or substituted, heteroaryl unsubstituted or substituted and heterocyclic unsubstituted or substituted, W is selected from the group comsisting of --(CH.sub.2).sub.n.sbsb.1 --or --(CH.sub.2).sub.n.sbsb.2 --NY--(CH.sub.2).sub.n.sbsb.3, n.sub.1, n.sub.2 and n.sub.3 are individually integers from 2 to 6, Y is selected from the group consisting of hydrogen, alkyl of 1 to 12 carbon atoms, aryl of 6 to 12 carbon atoms and aralkyl of 7 to 14 carbon atoms unsubstituted or substituted, --COOAlk and --COR.sub.2, Alk is alkyl of 1 to 12 carbon atoms, R.sub.2 is selected from the group consisting of alkyl of 1 to 12 carbon atoms, alkenyl and alkynyl of 2 to 12 carbon atoms, aryl of 6 to 14 carbon atoms, aralkyl of 7 to 18 carbon atoms unsubstituted or substituted and heterocyclic unsubstituted or substituted, Z is selected from the group consisting of hydrogen, ##STR2## R.sub.2 is alkyl of 1 to 12 carbon atoms or aralkyl of 7 to 18 carbon atoms, Alk' is alkyl of 1 to 12 carbon atoms, ArAlk is aralkyl of 7 to 18 carbon atoms, R.sub.2 ' is R.sub.2, R.sub.3 and R.sub.3 ' are selected from the group consisting of aryl substituted or unsubstituted, heteroaryl substituted or unsubstituted, heterocyclic unsubstituted or substituted and R.sub.1 with the proviso that Z is not hydrogen when W is --(CH.sub.2).sub.3 --and R.sub.1 is 2,4-dichlorophenoxy and their non-toxic, pharmaceutically acceptable acid addition salts having fungicidal activity.
从以下化合物组中选择的一种化合物,其具有以下通式:
##STR1##
其中,R1 选自以下组:Ar-O-、芳基、多芳基、稠合多芳基,这些基团未被取代或被取代,以及未被取代或被取代的杂环;Ar 是未被取代或被取代的具有6至14个碳原子的芳基、未被取代或被取代的杂芳基、未被取代或被取代的杂环;W 选自以下组:--(CH2)n1-- 或 --(CH2)n2--NY--(CH2)n3--,其中 n1、n2 和 n3 各自为2至6的整数;Y 选自以下组:氢、具有1至12个碳原子的烷基、具有6至12个碳原子的芳基、具有7至14个碳原子的芳烷基,这些基团未被取代或被取代,以及 --COOAlk 和 --COR2,其中 Alk 是具有1至12个碳原子的烷基,R2 选自以下组:具有1至12个碳原子的烷基、具有2至12个碳原子的烯基和炔基、具有6至14个碳原子的芳基、具有7至18个碳原子的芳烷基,这些基团未被取代或被取代,以及未被取代或被取代的杂环;Z 选自以下组:氢、##STR2## 其中 R2 是具有1至12个碳原子的烷基或具有7至18个碳原子的芳烷基,Alk' 是具有1至12个碳原子的烷基,ArAlk 是具有7至18个碳原子的芳烷基,R2' 是 R2,R3 和 R3' 选自以下组:被取代或未被取代的芳基、被取代或未被取代的杂芳基、未被取代或被取代的杂环,以及 R1,但条件是当 W 是 --(CH2)3-- 且 R1 是 2,4-二氯苯氧基时,Z 不是氢;以及它们的非毒性、药学上可接受的酸加成盐,具有杀菌活性。