甲基-Β-D-吡喃葡萄糖苷半水合物 | 7000-27-3

• 物质功能分类: 生物化工 - 糖类化合物 - 单糖
• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: 甲基-Β-D-吡喃葡萄糖苷半水合物
• 英文名称: methyl-beta-D-glucopyranoside hemihydrate
• 英文别名: (2R,3S,4S,5R,6R)-2-(hydroxymethyl)-6-methoxyoxane-3,4,5-triol;hydrate
• CAS: 7000-27-3
• 化学式: C14H30O13
• 分子量: 406.38
• InChiKey: CTOZFQQBPKUGJI-LOEDHUTHSA-N

物化性质

• 熔点：
  107-111 °C
• 溶解度：
  在水中的溶解度0.1 g/mL，澄清，无色

计算性质

• 辛醇/水分配系数(LogP)：
  -5.96
• 重原子数：
  27
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  200
• 氢给体数：
  9
• 氢受体数：
  13

安全信息

• TSCA：
  Yes
• 安全说明：
  S24/25
• WGK Germany：
  3
• 海关编码：
  29329900

文献信息

• Cryptophycin antibody conjugates for the treatment of cancer
  申请人：SANOFI

  公开号：US11007275B2

  公开（公告）日：2021-05-18

  The present disclosure relates to compounds of formula (V): wherein Ab represents an antibody. The disclosure also relates to cryptophycin payloads, as well as to cryptophycin conjugates, to compositions containing them and to their therapeutic use, especially as anticancer agents. The disclosure also relates to the process for preparing these conjugates.

  本公开涉及式（V）化合物： 其中 Ab 代表抗体。本公开还涉及隐球菌苷有效载荷、隐球菌苷共轭物、含有它们的组合物及其治疗用途，特别是作为抗癌剂。本公开还涉及制备这些共轭物的工艺。
• NOVEL PEPTIDIC LINKERS AND CRYPTOPHYCIN CONJUGATES, THEIR PREPARATION AND THEIR THERAPEUTIC USE
  申请人：SANOFI

  公开号：US20200054760A1

  公开（公告）日：2020-02-20

  The present disclosure relates to compounds of formula (I): RCG1-L-P  (I) wherein RCG1 represents a reactive chemical group being reactive towards a chemical group present on a polypeptide such as an antibody; P represents H, OH or an activated O; and L represents a specific linker. The disclosure also relates to cryptophycin payloads, as well as to cryptophycin conjugates, to compositions containing them and to their therapeutic use, especially as anticancer agents. The disclosure also relates to the process for preparing these conjugates.