2-联苯-4-氟乙酸 | 87293-37-6

• 物质功能分类: 有机原料 - 羧酸类化合物及衍生物
• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 2-联苯-4-氟乙酸
• 中文别名: 4'-氟-2-联苯乙酸
• 英文名称: 2-(4'-fluorobiphenyl-2-yl)acetic acid
• 英文别名: 2-[2-(4-fluorophenyl)phenyl]acetic Acid
• CAS: 87293-37-6
• 化学式: C₁₄H₁₁FO₂
• 分子量: 230.239
• InChiKey: OEXCPMVXXPJZES-UHFFFAOYSA-N

物化性质

• 沸点：
  399.1±30.0 °C(Predicted)
• 密度：
  1.235±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-联苯-4-氟乙酸 在 dipotassium peroxodisulfate 作用下， 以 水 为溶剂， 以70 %的产率得到2-氟-9-芴酮
  参考文献：
  名称：

  pH-Controlled Intramolecular Decarboxylative Cyclization of Biarylacetic Acids: Implication on Umpolung Reactivity of Aroyl Radicals

  摘要：

  DOI：

  10.1021/acs.joc.2c00295
• 作为产物：
  描述：

  2-(2-溴苯基)乙酸甲酯 在 四(三苯基膦)钯 、 sodium carbonate 、 potassium hydroxide 作用下， 以 四氢呋喃 、 甲醇 、 水 为溶剂， 生成 2-联苯-4-氟乙酸
  参考文献：
  名称：

  pH-Controlled Intramolecular Decarboxylative Cyclization of Biarylacetic Acids: Implication on Umpolung Reactivity of Aroyl Radicals

  摘要：

  DOI：

  10.1021/acs.joc.2c00295

文献信息

• RENIN INHIBITORS
  申请人：Jones Benjamin

  公开号：US20100210635A1

  公开（公告）日：2010-08-19

  Compounds, pharmaceutical compositions, kits and methods are provided for use with Renin that comprise a compound selected from the group consisting of: wherein the variables are as defined herein.

  提供了用于与Renin一起使用的化合物、药物组合物、试剂盒和方法，其中包括从以下组中选择的化合物：其中变量如本文所定义。
• BIPHENYLACETAMIDE DERIVATIVE
  申请人：Iwama Seiji

  公开号：US20110224304A1

  公开（公告）日：2011-09-15

  The present invention provides a compound of formula (I) or a salt thereof, wherein R 1 , R 2 and R 3 are independently selected from the group consisting of hydrogen atom, fluorine atom, chlorine atom, bromine atom, C 1-6 alkyl, C 1-6 alkoxy substituted with fluorine atom, and others; R 4 and R 5 are independently selected from the group consisting of hydrogen atom, fluorine atom, chlorine atom, C 1-6 alkyl, C 1-6 alkoxy substituted with fluorine atom, and others; R 6 and R 7 are independently selected from the group consisting of hydrogen atom, fluorine atom, methyl, ethyl, hydroxy group, and others; and R 8 and R 9 are independently selected from the group consisting of hydrogen atom, C 1-6 alkyl, and others, which is useful as an agent for treating or preventing various types of epilepsy including partial seizures and/or generalized seizures.

  本发明提供了化合物的化学式（I）或其盐，其中R1、R2和R3分别独立地选自氢原子、氟原子、氯原子、溴原子、C1-6烷基、用氟原子取代的C1-6烷氧基等；R4和R5分别独立地选自氢原子、氟原子、氯原子、C1-6烷基、用氟原子取代的C1-6烷氧基等；R6和R7分别独立地选自氢原子、氟原子、甲基、乙基、羟基等；R8和R9分别独立地选自氢原子、C1-6烷基等，该化合物可用作治疗或预防各种类型的癫痫，包括部分发作和/或全面发作。
• [EN] 4,5-SUBSTITUTED IMIDAZOLYL COMPOUNDS FOR THE TREATMENT OF INFLAMMATION<br/>[FR] COMPOSES D'IMIDAZOLYLE SUBSTITUES EN POSITIONS 4 ET 5, CONVENANT AU TRAITEMENT DE L'INFLAMMATION
  申请人：G.D. SEARLE & CO.

  公开号：WO1996003387A1

  公开（公告）日：1996-02-08

  (EN) A class of compounds is described for treating inflammation and inflammation-related disorders. Compounds of particular interest are defined by formula (I), wherein R1 is selected from lower alkyl, lower haloalkyl, lower hydroxyalkyl, lower alkoxyalkyl, lower alkenyloxyalkyl, mercapto, lower alkylcarbonyl, lower haloalkylcarbonyl, phenylcarbonyl, lower aralkylcarbonyl, lower aralkenyl, lower aryloxyalkyl, lower aralkyloxyalkyl, lower arylsulfonyl, lower aralkylsulfonyl, lower arylthioalkyl, lower heteroarylalkylthioalkyl, and heteroaryl selected from 2-thienyl, 2-furyl, 3-furyl, 2-pyridyl, 4-pyridyl and 2-benzofuryl; wherein R2 and R3 are independently selected from heteroaryl, cycloalkyl and aryl, wherein the heteroaryl, cycloalkyl and aryl radicals are substituted at a substitutable position with one or more radicals selected from hydrido, halo, lower alkylthio, lower alkylsulfinyl, lower alkylsulfonyl, aminosulfonyl, lower alkyl, cyano, carboxyl, lower alkoxycarbonyl, lower haloalkyl, hydroxyl, lower alkoxy, lower hydroxyalkyl, lower alkoxyalkyl, lower haloalkoxy, amino, lower alkylamino, phenylamino and nitro; and wherein R4 is selected from hydrido, lower alkyl and acyl; or a pharmaceutically acceptable salt thereof.(FR) La présente invention concerne une classe de composés convenant au traitement de l'inflammation et des troubles liés à l'inflammation. Les composés concernés en l'occurrence sont décrits par la formule générale (I). Dans cette formule générale (I), 'R1' est choisi parmi alkyle inférieur, haloalkyle inférieur, hydroxyalkyle inférieur, alcoxyalkyle inférieur, alcényloxyalkyle inférieur, mercapto, alkylcarbonyle inférieur, haloalkylcarbonyle inférieur, phénylcarbonyle, aralkylcarbonyle inférieur, aralcényle inférieur, aryloxyalkyle inférieur, aralkyloxyalkyle inférieur, arylsulfonyle inférieur, aralkylsulfonyle inférieur, arylthioalkyle inférieur, hétéroarylalkylthioalkyle inférieur, et hétéroaryle choisi parmi 2-thiényle, 2-furyle, 3-furyle, 2-pyridyle, 4-pyridyle et 2-benzofuryle. Dans la formule générale (I), 'R2' et 'R3' sont choisis séparément parmi hétéroaryle, cycloalkyle et aryle, les radicaux hétéroaryle, cycloalkyle et aryle étant substitués à des positions admettant la substitution par un ou plusieurs radicaux choisis parmi hydrido, halo, alkylthio inférieur, alkylsulfinyle inférieur, alkylsulfonyle inférieur, aminosulfonyle, alkyle inférieur, cyano, carboxyle, alcoxycarbonyle inférieur, haloalkyle inférieur, hydroxyle, alcoxy inférieur, hydroxyalkyle inférieur, alcoxyalkyle inférieur, haloalcoxy inférieur, amino, alkylamino inférieur, phénylamino et nitro. Dans la formule générale (I), 'R4' est choisi parmi hydrido, alkyle inférieur et acyle. L'invention concerne également des sels de ces composés de formule générale qui sont pharmaceutiquement acceptables.

  描述了一类用于治疗炎症和炎症相关疾病的化合物。特别感兴趣的化合物由式（I）定义，其中R1从较低的烷基，较低的卤代烷基，较低的羟基烷基，较低的氧烷基，较低的烯氧基烷基，巯基，较低的烷基羰基，较低的卤代烷基羰基，苯基羰基，较低的芳基烷基羰基，较低的芳基烯基，较低的芳氧基烷基，较低的芳基氧烷基，较低的芳基磺酰基，较低的芳基烷基磺酰基，较低的芳基硫代烷基，较低的杂环芳基烷基硫代烷基和杂环芳基，所述杂环芳基选择自2-噻吩基，2-呋喃基，3-呋喃基，2-吡啶基，4-吡啶基和2-苯并呋喃基；其中R2和R3分别选择自杂环芳基，环烷基和芳基，其中杂环芳基，环烷基和芳基基团在可取代位置上用一个或多个基团进行取代，所述基团选择自氢基，卤素基，较低的烷基硫基，较低的烷基亚砜基，较低的烷基磺酰基，氨基磺酰基，较低的烷基，氰基，羧基，较低的烷氧基羰基，较低的卤代烷基，羟基，较低的氧烷基，较低的羟基烷基，较低的氧烷基烷基，较低的卤代氧烷基，氨基，较低的烷基氨基，苯基氨基和硝基；其中R4选择自氢基，较低的烷基和酰基；或其药学上可接受的盐。
• 4,5-subtstituted imdazolyl compounds for the treatment of inflammation
  申请人：G.D. Searle & Co.

  公开号：US20030050330A1

  公开（公告）日：2003-03-13

  A class of compounds is described for treating inflammation and inflammation-related disorders. Compounds of particular interest are defined by Formula I 1 wherein R 1 is selected from lower alkyl, lower haloalkyl, lower hydroxyalkyl, lower alkoxyalkyl, lower alkenyloxyalkyl, mercapto, lower alkylcarbonyl, lower haloalkylcarbonyl, phenylcarbonyl, lower aralkylcarbonyl, lower aralkenyl, lower aryloxyalkyl, lower aralkyloxyalkyl, lower arylsulfonyl, lower aralkylsulfonyl, lower arylthioalkyl, lower heteroarylalkylthioalkyl, and heteroaryl selected from 2 -thienyl, 2 -furyl, 3 -furyl, 2 -pyridyl, 4 -pyridyl and 2 -benzofuryl; wherein R 2 and R 3 are independently selected from heteroaryl, cycloalkyl and aryl, wherein the heteroaryl, cycloalkyl and aryl radicals are substituted at a substitutable position with one or more radicals selected from hydrido, halo, lower alkylthio, lower alkylsulfinyl, lower alkylsulfonyl, aminosulfonyl, lower alkyl, cyano, carboxyl, lower alkoxycarbonyl, lower haloalkyl, hydroxyl, lower alkoxy, lower hydroxyalkyl, lower alkoxyalkyl, lower haloalkoxy, amino, lower alkylamino, phenylamino and nitro; and wherein R 4 is selected from hydrido, lower alkyl and acyl; or a pharmaceutically-acceptable salt thereof.

  描述了一类化合物，用于治疗炎症和与炎症相关的疾病。特别感兴趣的化合物由公式I1定义，其中R1选自较低的烷基，较低的卤代烷基，较低的羟基烷基，较低的烷氧基烷基，较低的烯氧基烷基，巯基，较低的烷基羰基，较低的卤代烷基羰基，苯基羰基，较低的芳基烷基羰基，较低的芳基烯基，较低的芳氧基烷基，较低的芳基氧烷基，较低的芳基磺酰基，较低的芳基烷基磺酰基，较低的芳基硫代烷基，较低的杂芳基烷基硫代烷基，和杂芳基，所述杂芳基选自2-噻吩基，2-呋喃基，3-呋喃基，2-吡啶基，4-吡啶基和2-苯并呋喃基；其中R2和R3分别选自杂芳基，环烷基和芳基，所述杂芳基，环烷基和芳基基团在可取代的位置上用一个或多个基团选自氢，卤素，较低的烷基硫，较低的烷基亚砜，较低的烷基磺酰基，氨基磺酰基，较低的烷基，氰基，羧基，较低的烷氧基羰基，较低的卤代烷基，羟基，较低的烷氧基，较低的羟基烷基，较低的烷氧基烷基，较低的卤代芳基氧基，氨基，较低的烷基氨基，苯基氨基和硝基；其中R4选自氢，较低的烷基和酰基；或其药学上可接受的盐。
• PHARMACEUTICAL COMPOSITION AND METHOD
  申请人：Slade Rachel M.

  公开号：US20090155903A1

  公开（公告）日：2009-06-18

  The invention provides compounds, pharmaceutical compositions and methods for the therapeutic treatment and prevention of neurodegenerative disorder and other Aβ 42 -related diseases and disorders.

  该发明提供了化合物、制药组合物和方法，用于治疗和预防神经退行性疾病和其他与Aβ42相关的疾病和障碍。