13-ethyltetrahydroberberine

• 分子结构分类: 有机化合物 - 生物碱及其衍生物 - 原小檗碱生物碱及其衍生物
• 英文名称: 13-ethyltetrahydroberberine
• 英文别名: (1R,21S)-21-ethyl-16,17-dimethoxy-5,7-dioxa-13-azapentacyclo[11.8.0.02,10.04,8.015,20]henicosa-2,4(8),9,15(20),16,18-hexaene
• 化学式: C₂₂H₂₅NO₄
• 分子量: 367.445
• InChiKey: OMQVKHLKFUWFAR-LHSJRXKWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  27
• 可旋转键数：
  3
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  40.2
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  2,3-methylenedioxy-9,10-dimethoxy-13-ethylprotoberberine chloride 在 sodium tetrahydroborate 作用下， 以 乙醇 为溶剂， 以85%的产率得到13-ethyltetrahydroberberine
  参考文献：
  名称：

  一种新型高效合成13-甲基小pro碱生物碱

  摘要：

  通过相应的原小-8碱（1）通过13-亚甲基-8、14-环小bin碱的光化学环化反应，有效地合成了13-甲基小ber碱（6a），脱氢科达林（6b）和corysamine（6c及其四氢衍生物（9a - c）。（3）。

  DOI：

  10.1039/c39850001257

文献信息

• A novel and efficient synthesis of 13-methylprotoberberine alkaloids
  作者：Miyoji Hanaoka、Shuji Yoshida、Chisato Mukai

  DOI：10.1039/c39850001257

  日期：——

  13-Methylberberine (6a), dehydrocorydaline (6b), and corysamine (6c, and their tetrahydro derivatives (9a–c) were efficiently synthesised from the corresponding protoberberines (1) through photochemical electrocyclic reaction of 13-methylene-8, 14-cycloberbines (3).

  通过相应的原小-8碱（1）通过13-亚甲基-8、14-环小bin碱的光化学环化反应，有效地合成了13-甲基小ber碱（6a），脱氢科达林（6b）和corysamine（6c及其四氢衍生物（9a - c）。（3）。
• Synthesis and structure–activity relationships of novel, substituted 5,6-dihydrodibenzo[a,g]quinolizinium P2X7 antagonists
  作者：Ga Eun Lee、Ho-Sung Lee、So Deok Lee、Jung-Ho Kim、Won-Ki Kim、Yong-Chul Kim

  DOI：10.1016/j.bmcl.2008.11.088

  日期：2009.2

  Iminium quaternary protoberberine alkaloids (QPA) have been found to be novel P2X(7) antagonists. To assess their structure-activity relationships, these compounds were modified at their R-1 and R-2 groups and assayed for their ability to inhibit the 2'(3')-O-(4-benzoylbenzoyl)-ATP (BzATP)-induced uptake of fluorescent ethidium by HEK-293 cells stably expressing the human P2X(7) receptor, and their ability to inhibit BzATP-induced IL-1 beta release by differentiated THP-1 cells. Compounds 15a and 15d, with alkyl groups at the R-1 position, and especially compound 19h, with the 2-NO2-4,5-dimethoxy-benzyl group at the R-2 position, had potent inhibitory efficacy as P2X(7) antagonists. (C) 2008 Elsevier Ltd. All rights reserved.
• Antibacterial activity and structure-activity relationships of berberine analogs
  作者：K Iwasa、M Kamigauchi、M Ueki、M Taniguchi

  DOI：10.1016/0223-5234(96)85167-1

  日期：1996.1

  Analogs of berberine 1 and related compounds were prepared to evaluate structure-activity relationships. Among the 13-alkyl-substituted and the 13-unsubstituted protoberberinium salts, the 13-ethyl-9-ethoxyl homolog 30, the 13-ethyl analog 29, and the 13-methyl derivative 3 showed an increase in antibacterial activity against Staphylococcus aureus by eight-, four- and twofold respectively over the parent base berberine 1; this is suggestive that steric effects play a significant role in the antibacterial. activity. Reduction of the protoberberinium salts yielding the tetrahydro derivatives greatly reduced the antibacterial activity. Replacement of methoxyl groups at the C-2 and the C-3 of ring A by a methylenedioxy group resulted in increased antibacterial activity. These data strongly suggest that the quaternary nitrogen atom such as in protoberberinium salts, an alkylsubstituent at C-13, and a methylenedioxy function at C-2 and C-3 are required for enhanced activity. Tetrahydroprotoberberine alpha-N-metho salts showed higher activity than tetrahydroprotoberberine hydrochlorides, but appreciably lower activity than protoberberinium salts. The effects of substitution at C-13 and on ring A in the alpha-N-metho salt were similar to those in protoberberinium salts. Stereochemical changes of the B/C ring juncture from trans to cis, and of the methyl group at C-13 from alpha to beta, had, respectively, marked and slight effects on the activity. The tested compounds were less active against Escherichia coli (Gram-negative bacterium) and Candida albicans (fungus) than S aureus (Gram-positive bacterium).
• HANAOKA, MIYOJI;YOSHIDA, SHUJI;MUKAI, CHISATO, CHEM. AND PHARM. BULL., 37,(1989) N2, C. 3264-3267
  作者：HANAOKA, MIYOJI、YOSHIDA, SHUJI、MUKAI, CHISATO

  DOI：——

  日期：——
• Chemical transformation of protoberberines. XV. A novel and efficient method for the introduction of alkyl groups on the C-13 position in the protoberberine skeleton.
  作者：Miyoji HANAOKA、Shuji YOSHIDA、Chisato MUKAI

  DOI：10.1248/cpb.37.3264

  日期：——

  The Wittig reaction of 8, 14-cycloberbin-13-ones (4), derived from the corresponding protoberberine alkaloids (2), with methylenetriphenylphosphorane afforded 13-methylene-8, 14-cycloberbines (5). Irradiation of 5 with a 100 W high pressure mercury lamp effected photochemically-induced electrocyclic fission of the aziridine ring to yield 13-methylberberine (1a), dehydrocorydaline (1b), and corysamine (1c) in high yield. Introduction of ethyl and propyl groups on the C-13 position in 2 was also conveniently achieved via photochemical reaction of the corresponding alkylidene derivatives (8 and 9, respectively).

  8, 14-环贝尔本-13-酮（4）通过与甲烯三苯基膦的维蒂格反应，来自相应的原贝尔巴林生物碱（2），得到13-亚甲基-8, 14-环贝尔本（5）。使用100 W高压汞灯对5进行辐照，促进了光化学诱导的电环裂解，生成高产率的13-甲基贝尔巴林（1a）、去氢可可碱（1b）和可可酸（1c）。通过相应烷基烯烃衍生物（8和9）进行光化学反应，还方便地在2的C-13位引入了乙基和丙基取代基。