4a-morpholin-4-yl-9-phenyl-10-phenylsulfonyl-1,2,3,4,4a,9,9a,10-octahydroacridine | 1145656-08-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 4a-morpholin-4-yl-9-phenyl-10-phenylsulfonyl-1,2,3,4,4a,9,9a,10-octahydroacridine
• 英文别名: 4-[10-(Benzenesulfonyl)-9-phenyl-1,2,3,4,9,9a-hexahydroacridin-4a-yl]morpholine；4-[10-(benzenesulfonyl)-9-phenyl-1,2,3,4,9,9a-hexahydroacridin-4a-yl]morpholine
• CAS: 1145656-08-1
• 化学式: C₂₉H₃₂N₂O₃S
• 分子量: 488.651
• InChiKey: SLTFLEUISTZXTA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.4
• 重原子数：
  35
• 可旋转键数：
  4
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  58.2
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  4a-morpholin-4-yl-9-phenyl-10-phenylsulfonyl-1,2,3,4,4a,9,9a,10-octahydroacridine 在 氢溴酸 作用下， 以 四氢呋喃 、 溶剂黄146 为溶剂， 反应 6.0h， 以81%的产率得到9-phenyl-10-phenylsulfonyl-1,2,3,4,9,9a-hexahydroacridine
  参考文献：
  名称：

  Quinoline Derivatives by Cyclocondensation of N-(2-Bromophenylmethylphenyl)benzenesulfonamide with Enol Ethers and Enamines

  摘要：

  The reaction of N-(2-bromophenylmethylphenyl)benzenesulfonamide (1) with electron rich alkenes (enol ethers (2), (3) and enamines (4)) gives quinoline derivatives 5 and ring fused quinoline 6, 7 whose structures were assigned on the basis of analytical and spectroscopic data. The chemical behavior of adducts 5 and 7 is reported.

  DOI：

  10.3987/com-08-s(f)50
• 作为产物：
  描述：

  N-{2-[bromo(phenyl)methyl]phenyl}benzenesulfonamide 、 1-吗啉基-1-环己烯 在 sodium hydride 作用下， 以 N,N-二甲基乙酰胺 、 mineral oil 为溶剂， 以92%的产率得到4a-morpholin-4-yl-9-phenyl-10-phenylsulfonyl-1,2,3,4,4a,9,9a,10-octahydroacridine
  参考文献：
  名称：

  Quinoline Derivatives by Cyclocondensation of N-(2-Bromophenylmethylphenyl)benzenesulfonamide with Enol Ethers and Enamines

  摘要：

  The reaction of N-(2-bromophenylmethylphenyl)benzenesulfonamide (1) with electron rich alkenes (enol ethers (2), (3) and enamines (4)) gives quinoline derivatives 5 and ring fused quinoline 6, 7 whose structures were assigned on the basis of analytical and spectroscopic data. The chemical behavior of adducts 5 and 7 is reported.

  DOI：

  10.3987/com-08-s(f)50

文献信息

• Quinoline Derivatives by Cyclocondensation of N-(2-Bromophenylmethylphenyl)benzenesulfonamide with Enol Ethers and Enamines
  作者：Piero Dalla Croce、Giuseppe Cremonesi、Francesco Fontana、Concetta La Rosa

  DOI：10.3987/com-08-s(f)50

  日期：——

  The reaction of N-(2-bromophenylmethylphenyl)benzenesulfonamide (1) with electron rich alkenes (enol ethers (2), (3) and enamines (4)) gives quinoline derivatives 5 and ring fused quinoline 6, 7 whose structures were assigned on the basis of analytical and spectroscopic data. The chemical behavior of adducts 5 and 7 is reported.