3,4-二溴呋喃 | 32460-02-9

• 物质功能分类: 有机原料 - 杂环化合物
• 分子结构分类: 有机化合物 - 有机卤素化合物 - 芳基卤化物
• 中文名称: 3,4-二溴呋喃
• 英文名称: 3,4-dibromofuran
• CAS: 32460-02-9
• 化学式: C₄H₂Br₂O
• mdl: MFCD01318995
• 分子量: 225.867
• InChiKey: ZBNAIRILIJMDEE-UHFFFAOYSA-N

物化性质

• 熔点：
  6°C(lit.)
• 沸点：
  166°C(lit.)
• 密度：
  2.2

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  7
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  13.1
• 氢给体数：
  0
• 氢受体数：
  1

安全信息

• 海关编码：
  2932190090
• 包装等级：
  III
• 危险类别：
  8,6.1
• 危险性防范说明：
  P264,P270,P280,P301+P310+P330,P305+P351+P338+P310,P405,P501
• 危险品运输编号：
  2922
• 危险性描述：
  H301,H318
• 储存条件：
  2-8°C

SDS

Material Safety Data Sheet

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Section 1. Identification of the substance
Product Name: 3,4-Dibromofuran
Synonyms:

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Section 2. Hazards identification
Harmful by inhalation, in contact with skin, and if swallowed.

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Section 3. Composition/information on ingredients.
Ingredient name: 3,4-Dibromofuran
CAS number: 32460-02-9

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Section 4. First aid measures
Skin contact: Immediately wash skin with copious amounts of water for at least 15 minutes while removing
contaminated clothing and shoes. If irritation persists, seek medical attention.
Eye contact: Immediately wash skin with copious amounts of water for at least 15 minutes. Assure adequate
flushing of the eyes by separating the eyelids with fingers. If irritation persists, seek medical
attention.
Inhalation: Remove to fresh air. In severe cases or if symptoms persist, seek medical attention.
Ingestion: Wash out mouth with copious amounts of water for at least 15 minutes. Seek medical attention.

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Section 5. Fire fighting measures
In the event of a fire involving this material, alone or in combination with other materials, use dry
powder or carbon dioxide extinguishers. Protective clothing and self-contained breathing apparatus
should be worn.

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Section 6. Accidental release measures
Personal precautions: Wear suitable personal protective equipment which performs satisfactorily and meets local/state/national
standards.
Respiratory precaution: Wear approved mask/respirator
Hand precaution: Wear suitable gloves/gauntlets
Skin protection: Wear suitable protective clothing
Eye protection: Wear suitable eye protection
Methods for cleaning up: Mix with sand or similar inert absorbent material, sweep up and keep in a tightly closed container
for disposal. See section 12.
Environmental precautions: Do not allow material to enter drains or water courses.

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Section 7. Handling and storage
Handling: This product should be handled only by, or under the close supervision of, those properly qualified
in the handling and use of potentially hazardous chemicals, who should take into account the fire,
health and chemical hazard data given on this sheet.
Store in closed vessels, refrigerated.
Storage:

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Section 8. Exposure Controls / Personal protection
Engineering Controls: Use only in a chemical fume hood.
Personal protective equipment: Wear laboratory clothing, chemical-resistant gloves and safety goggles.
General hydiene measures: Wash thoroughly after handling. Wash contaminated clothing before reuse.

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Section 9. Physical and chemical properties
Appearance: Not specified
Boiling point: No data
No data
Melting point:
Flash point: No data
Density: No data
Molecular formula: C4H2Br2O
Molecular weight: 225.9

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Section 10. Stability and reactivity
Conditions to avoid: Heat, flames and sparks.
Materials to avoid: Oxidizing agents.
Possible hazardous combustion products: Carbon monoxide, hydrogen bromide.

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Section 11. Toxicological information
No data.

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Section 12. Ecological information
No data.

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Section 13. Disposal consideration
Arrange disposal as special waste, by licensed disposal company, in consultation with local waste
disposal authority, in accordance with national and regional regulations.

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Section 14. Transportation information
Non-harzardous for air and ground transportation.

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Section 15. Regulatory information
No chemicals in this material are subject to the reporting requirements of SARA Title III, Section
302, or have known CAS numbers that exceed the threshold reporting levels established by SARA
Title III, Section 313.

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SECTION 16 - ADDITIONAL INFORMATION
N/A

反应信息

• 作为反应物：
  描述：

  3,4-二溴呋喃 在 正丁基锂 、 硼酸三甲酯 作用下， 以 四氢呋喃 、 环己烷 为溶剂， 反应 2.0h， 以75%的产率得到furan-3,4-diyldiboronic acid
  参考文献：
  名称：

  유기 전기 발광 소자용 발광 재료, 이를 이용한 유기 전기 발광 소자 및 유기 전기 발광 소자용 재료

  摘要：

  提供了一种发光效率和热稳定性优异的新型芳香族化合物，以及其制备方法和包含该新型芳香族化合物的有机电子器件。

  公开号：

  KR20150021861A
• 作为产物：
  描述：

  丁炔二醇 在 potassium dichromate 、 溴 作用下， 生成 3,4-二溴呋喃
  参考文献：
  名称：

  同位素呋喃-（氩）n，n = 1,2，配合物及其振动平均结构的旋转光谱

  摘要：

  摘要 脉冲喷嘴傅里叶变换微波光谱已被用于观察呋喃-3,4-d 2 -(氩) 2 范德华配合物的旋转光谱。除了先前测量的两种同位素呋喃-和呋喃-2- d - 外，还测量了呋喃-3- d -、呋喃-3,4- d 2 - 和呋喃- d 4 - 氩配合物的旋转光谱氩气。已经为每个同位素体拟合了旋转和四次离心畸变常数。已经从旋转跃迁的超精细分裂中确定了呋喃-3-d-氩络合物的氘四极耦合常数。考虑大振幅范德华振动影响的模型已用于确定分子间结构参数。氩气位于距离 R = 3 处。539(2) A 来自呋喃 - 氩络合物的呋喃质心。已经发现氩向氧移动，包括 R 和呋喃主轴 c 之间的角度 θ = 9.7(2)°。在呋喃-（氩） 2 络合物中，两个氩原子在呋喃平面的上方和下方呈现对称位置，与呋喃-氩络合物相比，R 和 θ 几乎没有变化。

  DOI：

  10.1016/0022-2860(94)08494-3

文献信息

• Synthesis of Biaryls Using the Coupling Reaction of Diaryldimethyltins with Copper(II) Nitrate
  作者：Genta Harada、Masato Yoshida、Masahiko Iyoda

  DOI：10.1246/cl.2000.160

  日期：2000.2

  Cu(NO3)2·3H2O in THF proceeds smoothly at room temperature under ambient atmosphere to produce the corresponding biaryls in good to high yields. Diaryldimethyltins can be prepared in high yields by the reaction of aryllithiums with dichlorodimethyltin.

  二芳基二甲基锡与 Cu(NO3)2·3H2O 在 THF 中的偶联在室温和环境气氛下顺利进行，以良好或高产率制备相应的联芳基化合物。二芳基二甲基锡可以通过芳基锂与二氯二甲基锡的反应以高产率制备。
• POLYCYCLIC COMPOUND AND ORGANIC ELECTROLUMINESCENCE DEVICE INCLUDING THE SAME
  申请人：SAMSUNG DISPLAY CO., LTD.

  公开号：US20180123057A1

  公开（公告）日：2018-05-03

  Disclosed are a polycyclic compound and an organic electroluminescence device including the same. The polycyclic compound according to an embodiment is represented by the following Formula 1,

  公开了一种多环化合物和一个包含该化合物的有机电致发光设备。根据一个实施例，所公开的多环化合物由以下公式1表示：
• 一类IDO抑制剂及其应用
  申请人：上海华汇拓医药科技有限公司

  公开号：CN109897011A

  公开（公告）日：2019-06-18

  本发明实施例提供了通式(I)的化合物或其药学上可接受的盐、立体异构体、互变异构形式、多晶型物、溶剂合物、前药、代谢物或同位素衍生物，其中取代基R1、R2、R0的定义如说明书所记载；本发明所合成的小分子IDO抑制剂药效作用显著，安全性高，将有希望成为一类新型的抗肿瘤药物。
• Catalyst-Controlled Regiodivergent Dehydrogenative Heck Reaction of 4-Arylthiophene/Furan-3-Carboxylates
  作者：Shang Gao、Zijun Wu、Fei Wu、Aijun Lin、Hequan Yao

  DOI：10.1002/adsc.201600696

  日期：2016.12.22

  A catalyst‐controlled regiodivergent dehydrogenative Heck reaction of 4‐arylthiophene/furan‐3‐carboxylates has been realized. Use of a palladium catalyst led to the C‐5 alkenylation through electronic palladation, while a ruthenium catalyst favored the C‐2 alkenylation with the assistance of a directing group. This reaction exhibited good to excellent regioselectivities.

  已经实现了由催化剂控制的4-芳基噻吩/呋喃-3-羧酸酯的区域发散性Heck反应。使用钯催化剂可通过电子钯反应导致C-5烯基化，而钌催化剂则在一个导向基团的帮助下促进C-2烯基化。该反应表现出良好的至优异的区域选择性。
• 五元杂环氧代羧酸类化合物及其医药用途
  申请人：中国科学院上海药物研究所

  公开号：CN112724127B

  公开（公告）日：2023-02-17

  本发明涉及五元杂环氧代羧酸类化合物及其医药用途。具体地，本发明涉及如式(I)所示的化合物、药用盐、前药、水合物、溶剂合物或晶型，也涉及所述化合物的制备方法、包含所述化合物的药物组合物以及其作为I型干扰素的分泌调节剂，尤其是作为STING激动剂，以及在制备预防和/或治疗与I型干扰素相关疾病的药物中的医药用途。

表征谱图