(2R,3S,4R,5S)-2,3,4,5-Tetramethoxy-hexanedioyl dichloride | 565449-70-9

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (2R,3S,4R,5S)-2,3,4,5-Tetramethoxy-hexanedioyl dichloride
• 英文别名: (2S,3R,4S,5R)-2,3,4,5-tetramethoxyhexanedioyl dichloride
• CAS: 565449-70-9
• 化学式: C₁₀H₁₆Cl₂O₆
• 分子量: 303.139
• InChiKey: GOGRUPULYZVZJC-SOSBWXJGSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  18
• 可旋转键数：
  9
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  71.1
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  1,6-di-O-trityl-galactitol 在 chromium(VI) oxide 、 sodium hydroxide 、 氯化亚砜 、 草酰氯 、 硫酸 、 对甲苯磺酸 、 二甲基亚砜 、 三乙胺 、 N,N-二甲基甲酰胺 作用下， 以 四氢呋喃 、 甲醇 、 二氯甲烷 、 二甲基亚砜 、 丙酮 为溶剂， 反应 27.5h， 生成 (2R,3S,4R,5S)-2,3,4,5-Tetramethoxy-hexanedioyl dichloride
  参考文献：
  名称：

  A Novel Carbohydrate-Derived Side-Chain Polyether with Excellent Protein Resistance

  摘要：

  A novel carbohydrate-derived side-chain polyether was synthesized as a new biomaterial by condensation polymerization of monomers derived from natural occurring carbohydrates. Surface plasmon resonance spectroscopy studies demonstrated that this side-chain polyether has excellent resistance to nonspecific protein adsorption. The protein resistant capability of the side-chain polyether is comparable to that of oligoethylene glycol, a main-chain polyether that is, to date, the best protein resistant material. In addition to the excellent biocompatibility, the new polymer also combines biodegradability and functionalizability. With these combined good properties, this side-chain polyether is envisioned as a new biomaterial for many potential biomedical applications.

  DOI：

  10.1021/ja0349507

文献信息

• A Novel Carbohydrate-Derived Side-Chain Polyether with Excellent Protein Resistance
  作者：Mark Metzke、Jane Z. Bai、Zhibin Guan

  DOI：10.1021/ja0349507

  日期：2003.7.1

  A novel carbohydrate-derived side-chain polyether was synthesized as a new biomaterial by condensation polymerization of monomers derived from natural occurring carbohydrates. Surface plasmon resonance spectroscopy studies demonstrated that this side-chain polyether has excellent resistance to nonspecific protein adsorption. The protein resistant capability of the side-chain polyether is comparable to that of oligoethylene glycol, a main-chain polyether that is, to date, the best protein resistant material. In addition to the excellent biocompatibility, the new polymer also combines biodegradability and functionalizability. With these combined good properties, this side-chain polyether is envisioned as a new biomaterial for many potential biomedical applications.