3,5-二氟戊基苯 | 121219-25-8

• 物质功能分类: 有机原料 - 烃类化合物及其衍生物 - 芳香烃
• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 3,5-二氟戊基苯
• 中文别名: 戊基-3,5-二氟苯
• 英文名称: 3,5-difluoro-1-pentylbenzene
• 英文别名: 1,3-difluoro-5-pentylbenzene；5-pentyl-1,3-difluorobenzene
• CAS: 121219-25-8
• 化学式: C₁₁H₁₄F₂
• 分子量: 184.229
• InChiKey: YDJZPOPHPSWRQV-UHFFFAOYSA-N

物化性质

• 密度：
  1.022

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  13
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  2

安全信息

• 海关编码：
  2903999090

反应信息

• 作为反应物：
  描述：

  3,5-二氟戊基苯 在 正丁基锂 作用下， 以 四氢呋喃 、 正己烷 为溶剂， 反应 2.5h， 以91%的产率得到2,6-difluoro-4-pentylbenzoic acid
  参考文献：
  名称：

  Gray, G. W.; Hird, M.; Lacey, D., Molecular Crystals and Liquid Crystals (1969-1991), 1989, vol. 172, p. 165 - 190

  摘要：

  DOI：
• 作为产物：
  描述：

  1-溴-3,5-二氟苯 在 palladium on activated charcoal 磷酸酐 、 ammonium chloride 、 氢气 、 magnesium 作用下， 以 四氢呋喃 、 乙醚 、 水 、 正戊烷 为溶剂， 反应 6.0h， 生成 3,5-二氟戊基苯
  参考文献：
  名称：

  Gray, G. W.; Hird, M.; Lacey, D., Molecular Crystals and Liquid Crystals (1969-1991), 1989, vol. 172, p. 165 - 190

  摘要：

  DOI：

文献信息

• New low polar tolane cholesterics designed for infrared applications
  作者：Jakub Herman、Przemysław Kula

  DOI：10.1039/c6ra16023a

  日期：——

  We have designed, synthesized and evaluated the physical properties of new fluorinated phenyltolane based chiral liquid crystal materials with 2-methylbutyl terminal chain. The 2- or 2,6-fluorosubstitution in combination with the phenyltolane core brings surprising improvement of mesomorphic properties. The investigated compounds are characterized by a broad temperature range of the cholesteric (chiral

  我们已经设计，合成和评估了具有2-甲基丁基末端链的新型氟化苯基甲苯基手性液晶材料的物理性能。2-或2,6-氟取代基与苯基tolane核心相结合，带来了令人惊奇的介晶性能改善。所研究的化合物的特征在于胆甾型（手性向列型N *）相的温度范围宽，熔融温度极低，并且易于在近红外区进行选择性反射的热控制。适中的螺旋扭曲力β，高的光学各向异性和蓝相的来源，使这些化合物对胆甾型混合物配方具有吸引力。
• Laterally fluorinated 4-cyanophenyl and 4'-cyanobiphenyl benzoates
  申请人：The Secretary of State for for Defence in Her Britannic Majesty's

  公开号：US05156763A1

  公开（公告）日：1992-10-20

  Laterally fluorinated 4-cyanophenyl and 4'-cyanobiphenyl benzoates are diosed of general formula I: ##STR1## in which R is R.sup.1 or R.sup.1 O, wherein R.sup.1 is C.sub.1 -C.sub.12 alkyl, m and n are 0 or 1 provided that (n+m) is 0 or 1, each of a, b, c and d are independently 0 or 1, provided (a+b+c+d) is not zero, but excluding the case where a and b are 0 and one of c and d is 0, being useful constituents of nematic liquid crystal materials.

  侧向氟代的4-氰基苯基和4'-氰基联苯基苯甲酸酯是一般式I的二聚体：##STR1## 其中R是R.sup.1或R.sup.1 O，其中R.sup.1是C.sub.1-C.sub.12烷基，m和n为0或1，前提是(n+m)为0或1，a、b、c和d中的每一个都是独立的0或1，前提是(a+b+c+d)不为零，但不包括a和b为0和c和d中的一个为0的情况，是向列相液晶材料中有用的组分。
• Manganese(<scp>iii</scp>) porphyrin-catalyzed regioselective dual functionalization of C(sp³)–H bonds: the transformation of arylalkanes to 1,4-diketones
  作者：Jakub Sukiennik、Audrey Pranowo、Sylwester Domański、Karolina Hurej

  DOI：10.1039/d2cc06126k

  日期：——

  We have developed a complete methodology for one-pot oxidation of arylalkanes to 1,4-diketones under mild conditions with high site-selectivity, using water as the main solvent and the most basic manganese(iii) porphyrin complex as a catalyst.

  我们已经开发出一种完整的方法，可以在温和条件下，高选择性地使用水作为主溶剂和最基本的锰（III）卟啉配合物作为催化剂，将芳基烷烃氧化为1,4-二酮。
• SIX-MEMBERED HETEROCYCLIC COMPOUND AND THE USE THEREOF
  申请人：Asahi Kasei Pharma Corporation

  公开号：EP1847533A1

  公开（公告）日：2007-10-24

  A compound represented by the general formula (I) or a salt thereof: [T represents oxygen atom and the like; V represents CH2 and the like; RO1 to RO4 represent hydrogen atom and the like; A represents a linear alkylene group or linear alkenylene group having 2 to 8 carbon atoms and the like; D represents carboxyl group and the like; X represents ethylene group, trimethylene group and the like; E represents -CH(OH)- group and the like; and W represent -U1-(RW1)(RW2)-U2-U3 group (U1 represents a single bond, an alkylene group having 1 to 4 carbon atoms and the like; RW1 and RW2 represent hydrogen atom and the like; U2 represents a single bond, an alkylene group having 1 to 4 carbon atoms and the like; and U3 represent an alkyl group having 1 to 8 carbon atoms and the like), or a residue of a carbon ring or heterocyclic compound], which can be utilized as an active ingredient of medicaments effective for prophylactic and/or therapeutic treatment of skeletal diseases such as osteoporosis and fracture, glaucoma, ulcerative colitis and the like.

  通式 (I) 所代表的化合物或其盐： [T 代表氧原子等；V 代表 CH2 等；RO1 至 RO4 代表氢原子等；A 代表具有 2 至 8 个碳原子的直链烯基或直链烯基等；D 代表羧基等；X 代表乙烯基、三亚甲基等；E 代表-CH(OH)- 基等；W 代表-U1-(RW1)(RW2)-U2-U3 基（U1 代表单键、具有 1 至 4 个碳原子的亚烷基等）；RW1 和 RW2 代表氢原子等；U2 代表单键、具有 1 至 4 个碳原子的亚烷基等；U3 代表具有 1 至 8 个碳原子的烷基等），或碳环或杂环化合物的残基]，可用作有效预防和/或治疗骨质疏松症和骨折等骨骼疾病、青光眼、溃疡性结肠炎等疾病的药物的活性成分。
• The synthesis of chiral fluorinated 4-alkyl-4′-[(4-alkylphenyl)ethynyl]biphenyls
  作者：Jakub Herman、Przemysław Kula

  DOI：10.1016/j.tetlet.2013.04.118

  日期：2013.7

  We have designed, synthesized, and evaluated the physical properties of new fluorinated phenyltolane based chiral liquid crystal materials with 2-methylbutyl chains. This type of fluoro-substitution in chemical combination with a phenyltolane core brings a surprising improvement to the mesomorphic properties. The investigated compounds exhibit broad temperature ranges for the N* phase and very low melting points. All homologues exhibited Blue Phase. We have applied a Cu-catalyzed cross-coupling reaction between aryl Grignard reagents and alkyl bromides for the synthesis of the products. (C) 2013 Elsevier Ltd. All rights reserved.