3,7,11-三甲基十二炔-3-醇 | 1604-35-9

• 物质功能分类: 化学试剂 - 有机试剂 - 炔烃
• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 中文名称: 3,7,11-三甲基十二炔-3-醇
• 英文名称: 3,7,11-trimethyldodecyn-3-ol
• 英文别名: 3,7,11-trimethyldodec-1-yn-3-ol；3,7,11-Trimethyl-1-dodecyn-3-ol
• CAS: 1604-35-9
• 化学式: C₁₅H₂₈O
• mdl: MFCD00778480
• 分子量: 224.387
• InChiKey: OWRXWSVBJIIORE-UHFFFAOYSA-N

物化性质

• 沸点：
  140-142℃ (13 Torr)
• 密度：
  0.8464 g/cm3(Temp: 25 °C)
• 保留指数：
  1483

计算性质

• 辛醇/水分配系数(LogP)：
  4.9
• 重原子数：
  16
• 可旋转键数：
  9
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.866
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

安全信息

• 海关编码：
  2905290000

反应信息

• 作为反应物：
  描述：

  3,7,11-三甲基十二炔-3-醇 在 溴 、 Petroleum ether 作用下， 生成 5-(3,7-dimethyl-octyl)-4-methyl-dihydro-furan-2-one
  参考文献：
  名称：

  Nasarow et al., Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1958, p. 1354,1360; engl. Ausg. S. 1306, 1311

  摘要：

  DOI：
• 作为产物：
  描述：

  六氢假紫罗酮 在 乙醚 、 sodium amide 作用下， 生成 3,7,11-三甲基十二炔-3-醇
  参考文献：
  名称：

  Fischer,F.G.; Loewenberg, Justus Liebigs Annalen der Chemie, 1929, vol. 475, p. 192

  摘要：

  DOI：

文献信息

• �ber eine neuartige Synthese von ?-Ketoallenen durch Reaktion von terti�ren Acetylencarbinolen mit Vinyl�thern eine ergiebige methode zur darstellung des Pseudojonons und verwandter verbindungen
  作者：G. Saucy、R. Marbet

  DOI：10.1002/hlca.19670500423

  日期：——

  The novel acid-catalysed reaction of isopropenyl ether with tertiary acetylenic carbinols to give β-ketoallenes in high yields is described. Upon treatment with bases, these allenes readily undergo isomerization to conjugated dienones. This reaction sequence results in an economic synthesis of pseudo-ionones and pseudo-irones from dehydrolinalool and its homologs.

  描述了异丙烯基醚与炔属叔丁醇的新型酸催化反应，以高收率得到β-酮基烯丙基。用碱处理后，这些人就容易进行异构化成共轭二烯酮。该反应序列导致由脱氢芳樟醇及其同系物经济地合成假紫罗兰酮和假熨斗。
• Preparation of higher alpha, beta-unsaturated alcohols
  申请人：——

  公开号：US20020183565A1

  公开（公告）日：2002-12-05

  Higher &agr;,&bgr;-unsaturated alcohols are prepared by monoethynylation of a ketone by the NH 3 /KOH method, if desired hydrogenation of the acetylene alcohol in the presence of hydrogen over a Pd-containing thin layer catalyst, purifying distillation of the hydrogenation product, preferably in a dividing wall column with recirculation of the unreacted ketone to the ethynylation step, and, if desired, preparation of higher alcohols having in each case 5 more carbon atoms in the chain by reacting the alcohols prepared by monoethynylation and, if desired, partial hydrogenation with alkyl acetoacetatesor diketene in a Carroll reaction to form ketones and using these as starting materials for the steps ethynylation, optional hydrogenation and fractional distillation.

  高级α，β-不饱和醇通过NH3/KOH方法对酮进行单乙炔基化制备，如有需要，在Pd含量薄层催化剂存在下，对乙炔醇进行加氢反应，纯化加氢产物的蒸馏，最好在带有循环未反应酮的分隔壁柱的条件下进行，然后，如有需要，通过将通过单乙炔基化制备的醇与如有需要的部分加氢后的醇与烯丙酮酸酯或二酮在Carroll反应中反应，形成酮，并将其用作乙炔基化、可选加氢和分馏步骤的起始原料，制备具有每个链中5个以上碳原子的高级醇。
• Process for the preparation of alkynediols
  申请人：DSM IP Assets B.V.

  公开号：EP1808426A1

  公开（公告）日：2007-07-18

  The present invention relates to a novel process for the manufacture of alkinediols of the formula I wherein ketones of the formula II are reacted with alkinols of the formula III in liquid ammonia in the presence of potassium hydroxide, wherein R1 and R3 are independently from each other a linear, branched or cyclic C2-25-carbon-hydrogen moiety, optionally containing 1 to 10 non-conjugated double-bond(s), and R2 and R4 are independently from each other linear C1-4-alkyl. The present invention also refers to the novel use of the alkindiols as emulgator, surfactant, dispersant, anti-foaming non-ionic agent, viscosity stabilizer, antistatic lubricant in the spinning of fibres, solvent, flavour, fragrance, wetting agent, sealing material or intermediate thereof and to the following novel alkindiols: 4,7-dihydroxy-2,4,7,9-tetramethyl-5-decine, 10, 13-dihydroxy-2,6,10,13,17,21-hexamethyl-11-docosine and 14, 17-dihydroxy-2,6,10,14,17,21,25,29-octamethyl-15-triacontine.

  本发明涉及一种用于制造化学式I的炔二醇的新工艺，其中化学式II的酮与化学式III的炔醇在液氨中在存在氢氧化钾的情况下反应，其中R1和R3分别是线性、支链或环状的C2-25碳氢基团，可选地含有1至10个非共轭双键，而R2和R4则分别是线性的C1-4烷基。本发明还涉及炔二醇作为乳化剂、表面活性剂、分散剂、抗泡沫非离子剂、粘度稳定剂、防静电润滑剂在纤维纺丝中的新用途，溶剂、香精、香料、润湿剂、密封材料或其中间体，以及以下新型炔二醇：4,7-二羟基-2,4,7,9-四甲基-5-癸烯，10,13-二羟基-2,6,10,13,17,21-六甲基-11-二十二烷和14,17-二羟基-2,6,10,14,17,21,25,29-八甲基-15-三十烷。
• Process for manufacturing cyclocarbonates using a silver salt catalyst
  申请人：Roche Vitamins Inc.

  公开号：US05817838A1

  公开（公告）日：1998-10-06

  A process for the manufacture of 4,4-disubstituted 5-methylene-1,3-dioxolan-2-ones ("cyclocarbonates") of the formula: ##STR1## wherein R.sup.1 and R.sup.2 each independently signify a saturated or olefinically-unsaturated aliphatic group or an aromatic group, or R.sup.1 and R.sup.2 together form tetra- or pentamethylene, by reacting a corresponding 3,3-disubstituted prop-1-yn-3-ol of the formula HC.tbd.C--C(R.sup.1)(R.sup.2)--OH (II) with carbon dioxide in the presence of a quaternary ammonium or phosphonium salt as the catalyst comprises using a silver salt as a further catalyst. An alkali metal or quaternary ammonium or phosphonium salt of a carboxylic acid can also be used to increase the catalytic performance of the silver salt catalyst. Moreover, the addition of triphenylphosphine serves to accelerate the reaction to some extent. The silver salts catalyze this process significantly better than the previously utilized copper salts. Advantageously, the process uses much smaller amounts of catalyst, significantly shortens reaction times, and mandates less drastic reaction conditions. Cyclocarbonates produced by this process are valuable intermediates for the production of polymerizates and other useful substances, such as dyestuffs and carotenoids.

  一种制备4,4-二取代5-亚甲基-1,3-二氧杂环己烷-2-酮（“环碳酸酯”）的工艺，化学式如下：其中R^1和R^2各自独立表示饱和或烯烃不饱和的脂肪基或芳香基，或者R^1和R^2共同形成四元或五元亚甲基，通过将相应的化学式为HC.tbd.C--C(R^1)(R^2)--OH（II）的3,3-二取代丙-1-炔-3-醇与二氧化碳在季铵盐或膦盐存在下反应而制备，包括使用银盐作为进一步的催化剂。碱金属或羧酸的季铵盐或膦盐也可用于提高银盐催化剂的催化性能。此外，三苯基膦的添加在一定程度上加速了反应。银盐催化这一过程比以前使用的铜盐显著更好。该工艺使用催化剂量较小，显著缩短了反应时间，并且要求的反应条件较不严苛。通过该工艺生产的环碳酸酯是用于生产聚合物和其他有用物质（如染料和类胡萝卜素）的有价值的中间体。
• METHOD OF HYDROSILYLATION IMPLEMENTING AN ORGANIC CATALYST DERIVED FROM GERMYLENE
  申请人：BLUESTAR SILICONES FRANCE SAS

  公开号：US20170313729A1

  公开（公告）日：2017-11-02

  The present invention concerns a method for the hydrosilylation of an unsaturated compound comprising at least one ketone function, one aldehyde function, one alkene function and/or one alkyne function, with a compound comprising at least one hydrogen-silyl function implementing an organic catalyst of tri-coordinated germanium.

  本发明涉及一种用于水硅烷基化不饱和化合物的方法，所述不饱和化合物包括至少一个酮基功能、一个醛基功能、一个烯烃功能和/或一个炔烃功能，与至少一个含有氢硅基功能的化合物反应，使用三配位的有机催化剂锗实施。