3,7-二甲基-(2E)-2,6-辛二烯-1-醇 1-(2-氨基苯甲酸酯) | 67874-69-5

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 中文名称: 3,7-二甲基-(2E)-2,6-辛二烯-1-醇 1-(2-氨基苯甲酸酯)
• 中文别名: 3,7-二甲基-(2E)-2,6-辛二烯-1-醇1-(2-氨基苯甲酸酯)
• 英文名称: (E)-3,7-dimethylocta-2,6-dienyl 2-aminobenzoate
• 英文别名: geranyl anthranilate；geranyl antranilate；anthranilic acid geranyl ester；Anthranilsaeure-geranylester；[(2E)-3,7-dimethylocta-2,6-dienyl] 2-aminobenzoate
• CAS: 67874-69-5
• 化学式: C₁₇H₂₃NO₂
• 分子量: 273.375
• InChiKey: QLRICECRKJGSKQ-SDNWHVSQSA-N

物化性质

• 熔点：
  140-141 °C
• 沸点：
  418.6±33.0 °C(Predicted)
• 密度：
  1.031±0.06 g/cm3(Predicted)
• 溶解度：
  Insoluble in water, soluble in alcohol, miscible with most oils. Almost insoluble in Propylene glycol.
• LogP：
  5.976 (est)
• 保留指数：
  2244.8

计算性质

• 辛醇/水分配系数(LogP)：
  5
• 重原子数：
  20
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  52.3
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  3,7-二甲基-(2E)-2,6-辛二烯-1-醇 1-(2-氨基苯甲酸酯) 、 1-溴-3-甲基-2-丁烯 在 四丁基碘化铵 、 三乙胺 作用下， 以 四氢呋喃 为溶剂， 反应 3.0h， 以88.2%的产率得到geranyl N-dimethylallylanthranilate
  参考文献：
  名称：

  Sharma; Sharma; Rathee, Raman, Journal of the Indian Chemical Society, 2006, vol. 83, # 11, p. 1158 - 1159

  摘要：

  DOI：
• 作为产物：
  描述：

  靛红酸酐 、 香叶醇 在 4-二甲氨基吡啶 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 3.0h， 以70%的产率得到3,7-二甲基-(2E)-2,6-辛二烯-1-醇 1-(2-氨基苯甲酸酯)
  参考文献：
  名称：

  Sharma; Sharma; Rathee, Raman, Journal of the Indian Chemical Society, 2006, vol. 83, # 11, p. 1158 - 1159

  摘要：

  DOI：

文献信息

• BITTER TASTE MODIFIERS INCLUDING SUBSTITUTED 1-BENZYL-3-(1-(ISOXAZOL-4-YLMETHYL)-1H-PYRAZOL-4-YL)IMIDAZOLIDINE-2,4-DIONES AND COMPOSITIONS THEREOF
  申请人：SENOMYX, INC.

  公开号：US20160376263A1

  公开（公告）日：2016-12-29

  The present invention includes compounds and compositions known to modify the perception of bitter taste, and combinations of said compositions and compounds with additional compositions, compounds, and products. Exemplary compositions comprise one or more of the following: cooling agents; inactive drug ingredients; active pharmaceutical ingredients; food additives or foodstuffs; flavorants, or flavor enhancers; food or beverage products; bitter compounds; sweeteners; bitterants; sour flavorants; salty flavorants; umami flavorants; plant or animal products; compounds known to be used in pet care products; compounds known to be used in personal care products; compounds known to be used in home products; pharmaceutical preparations; topical preparations; cannabis-derived or cannabis-related products; compounds known to be used in oral care products; beverages; scents, perfumes, or odorants; compounds known to be used in consumer products; silicone compounds; abrasives; surfactants; warming agents; smoking articles; fats, oils, or emulsions; and/or probiotic bacteria or supplements.

  本发明涵盖已知用于改变苦味感知的化合物和组合物，以及所述组合物和化合物与额外的组合物、化合物和产品的组合。示例组合物包括以下一种或多种：冷却剂；无活性药物成分；活性药用成分；食品添加剂或食品；调味剂或调味增强剂；食品或饮料产品；苦味化合物；甜味剂；苦味剂；酸味调味剂；咸味调味剂；鲜味调味剂；植物或动物产品；已知用于宠物护理产品中的化合物；已知用于个人护理产品中的化合物；已知用于家用产品中的化合物；制药制剂；局部制剂；大麻衍生或与大麻相关的产品；已知用于口腔护理产品中的化合物；饮料；香味、香水或除臭剂；已知用于消费品中的化合物；硅化合物；磨料；表面活性剂；发热剂；吸烟物品；脂肪、油脂或乳化剂；和/或益生菌或补充剂。
• [EN] A PERSONAL CARE COMPOSITION<br/>[FR] COMPOSITION DE SOINS PERSONNELS
  申请人：UNILEVER NV

  公开号：WO2018149578A1

  公开（公告）日：2018-08-23

  Disclosed is a personal care composition and a method of providing antiperspirant and anti-inflammation using certain curcuminoid derivatives. The composition comprises: (i) a compound of the Formula 1 Ar-CHnCHn-X.C(R)2-X.CHnCHn-Ar (Formula 1) wherein Ar is a substituted or unsubstituted phenyl group; R is H or CH3; X is CH(OH) group or C=O group; n has the value 1 or 2; and, (ii) a topically acceptable base comprising at least 0.1% of a fragrance wherein, when n=1, the compound of (Formula 1) is 1E,6E)-1,7-bis(3,4- dimethoxyphenyl)-4,4-dimethylhepta-1,6-diene-3,5-dione (Formula 2), and when n=2, the compound of (Formula 1) is 1,7-bis(4-hydroxy-3- methoxyphenyl) heptane-3,5-diol (Formula 4) or is 1,7-bis (3,4-dimethoxyphenyl)-4,4-dimethylheptane-3,5-diol (Formula 5).

  本文揭示了一种个人护理组合物和利用特定姜黄素衍生物提供止汗剂和抗炎作用的方法。该组合物包括：(i) 公式1 Ar-CHnCHn-X.C(R)2-X.CHnCHn-Ar（公式1）中的化合物，其中Ar是取代或未取代的苯基；R是H或CH3；X是CH(OH)基团或C=O基团；n的取值为1或2；以及，(ii) 至少含有0.1%香料的局部可接受基质，当n=1时，化合物（公式1）为1,7-双（3,4-二甲氧基苯基）-4,4-二甲基庚烯-1,6-二烯-3,5-二酮（公式2），当n=2时，化合物（公式1）为1,7-双（4-羟基-3-甲氧基苯基）庚烷-3,5-二醇（公式4）或为1,7-双（3,4-二甲氧基苯基）-4,4-二甲基庚烷-3,5-二醇（公式5）。
• COMPOUNDS USEFUL AS MODULATORS OF TRPM8
  申请人：Senomyx, Inc.

  公开号：US20170096418A1

  公开（公告）日：2017-04-06

  The present disclosure relates to compounds which are useful as cooling sensation compounds.

  本公开涉及作为冷感化合物有用的化合物。
• Multi-compartment storage and delivery containers and delivery system for microencapsulated fragrances
  申请人：Troost Herman Erik

  公开号：US20060102656A1

  公开（公告）日：2006-05-18

  Described is a multiple (2-4)-compartment fluidic individually stable pre-storable composition storage and unstable mixture-forming and delivery container having separate compartments each communicating with a single mixing zone via an externally-located fluidic composition multiple delivery tube system juxtaposed with the outer surfaces of the compartment walls. These containers are well suited for storing and transporting compositions such as a cleaning agent composition, a personal care composition, an aqueous liquid detergent composition and/or a fabric softening composition and then promptly delivering the resulting unstable mixture to the desired location. The container has been advantageously found to deliver unstable mixtures which could include aqueous suspensions of microencapsulated fragrances or other ingredients.

  本发明涉及一种多（2-4）隔室流体单独稳定的可储存组合物储存容器和不稳定混合物形成和输送容器，其具有单独的隔室，每个隔室通过外部定位的流体组成物多重输送管系与隔室壁的外表面相邻，与单个混合区域相通。这些容器非常适合存储和运输诸如清洁剂组合物、个人护理组合物、水性液体洗涤剂组合物和/或柔顺剂组合物等组合物，然后迅速将产生的不稳定混合物输送到所需位置。有利地发现，该容器可输送包括微囊化香料或其他成分的水性悬浮液等不稳定混合物。
• Skin and hair treatment composition and process for using same resulting in controllably-releasable fragrance and/or malodour counteractant evolution
  申请人：Winton Brooks Dee Clint

  公开号：US20050226900A1

  公开（公告）日：2005-10-13

  Described is a human epidermal and/or human hair treatment composition of (i) fragrance and/or malodour counteractant and (ii) fragrance- and/or malodour counteractant-compatible solvent-containing microcapsules provided in a suspension gel or emulsion. Also described is a method for delivery of fragrance and beneficial agents to the human epidermal surface area region treatment and/or human hair treatment wherein the microcapsules remain on the human epidermis and/or on the hair follicles for a substantial period of time subsequent to their application and the microcapsules are ruptured over a period of time, thereby effecting both an initial delivery of fragrance and beneficial agent subsequent to rubbing, and, in addition, a controlled release of fragrance and beneficial agents into to the treated human epidermis and/or hair follicles.

  本发明涉及一种人类表皮和/或人类头发处理组合物，其包括（i）香味和/或恶臭对抗剂和（ii）包含香味和/或恶臭对抗剂兼容的溶剂的微囊，所述微囊以悬浮凝胶或乳液形式提供。本发明还涉及一种将香味和有益成分传递到人类表皮表面区域处理和/或人类头发处理的方法，其中微囊在其应用后在人类表皮和/或毛囊上保持相当长的时间，并且微囊在一段时间内破裂，从而在摩擦后实现香味和有益成分的初始传递，并且还实现对处理的人类表皮和/或毛囊的香味和有益成分的控制释放。