甲基丙烯酸乙酯 - CAS号 97-63-2

物化性质

熔点：

-75 °C
沸点：

118-119 °C (lit.)
密度：

0.917 g/mL at 25 °C (lit.)
蒸气密度：

>3.9 (vs air)
闪点：

60 °F
溶解度：

水中的溶解度为5.1克/升
LogP：

1.940
物理描述：

Ethyl methacrylate appears as a colorless moderately toxic liquid with an acrid odor. Flash point of 70°F. Boiling point 278°F. Vapors irritate the eyes and respiratory system. Less dense than water. Not soluble in water. Used to make polymers and other chemicals.
颜色/状态：

Colorless, liquid
气味：

Acrid odor
蒸汽密度：

3.94 (NTP, 1992) (Relative to Air)
蒸汽压力：

20.59 mm Hg at 20 °C
自燃温度：

393 °C
分解：

When heated to decomposition, it emits acrid smoke and irritating fumes.
粘度：

0.92 mPa (cP)
燃烧热：

-7.040 cal/g (-294X10+5 J/kg; 12.670 Btu/lb)
汽化热：

96 cal/g (4.0X10+5 J/kg; 170 Btu/lb)
聚合：

Heat can cause a violent polymerization reaction with rapid release of energy.
折光率：

Index of refraction: 1.4147 at 20 °C/D
保留指数：

773;768;773;770;756;756;756;770.7;775;758.2;814
稳定性/保质期：
1. 本品毒性与甲基丙烯酸甲酯相近，经口LD₅₀为15mL/kg。防护要求与甲基丙烯酸甲酯相同，参见甲基丙烯酸甲酯。
2. 稳定性 [19]：稳定
3. 禁配物 [20]：强氧化剂、强酸、强碱
4. 应避免接触的条件 [21]：受热、光照、紫外线、空气
5. 聚合危害 [22]：聚合

计算性质

辛醇/水分配系数(LogP)：

1.9
重原子数：

8
可旋转键数：

3
环数：

0.0
sp3杂化的碳原子比例：

0.5
拓扑面积：

26.3
氢给体数：

0
氢受体数：

2

ADMET

代谢

甲基丙烯酸甲酯和其他短链烷基-甲基丙烯酸酯首先在多个组织中通过非特异性的羧酸酯酶水解为甲基丙烯酸和结构上相应的醇。/短链烷基-甲基丙烯酸酯/

Methyl methacrylate and other short chain alkyl-methacrylate esters are initially hydrolyzed by non-specific carboxylesterases to methacrylic acid and the structurally corresponding alcohol in several tissues. /Short chain alkyl-methacrylate esters/

来源:Hazardous Substances Data Bank (HSDB)

代谢

甲基丙烯酸酯可以在体外与谷胱甘肽（GSH）结合，尽管它们表现出较低的活性，因为双键处添加亲核试剂受到α-甲基侧链的阻碍...因此，酯水解被认为是烷基-甲基丙烯酸酯的主要代谢途径，而GSH结合在其代谢中仅发挥次要作用，可能只有在达到非常高的组织浓度时才会发生。/短链烷基-甲基丙烯酸酯/

Methacrylate esters can conjugate with glutathione (GSH) in vitro, although they show a low reactivity, since the addition of a nucleophile at the double bond is hindered by the alpha-methyl side-group ... Hence, ester hydrolysis is considered to be the major metabolic pathway for alkyl-methacrylate esters, with GSH conjugation only playing a minor role in their metabolism, and then possibly only when very high tissue concentrations are achieved. /Short chain alkyl-methacrylate esters/

来源:Hazardous Substances Data Bank (HSDB)

代谢

丙烯酸酯和甲基丙烯酸酯主要通过迈克尔加成反应或谷胱甘肽-S-转移酶与谷胱甘肽结合来进行解毒。它们还可能通过羧酸酯酶发生水解。较低分子量的酯类被迅速代谢和排出，因此，不太可能引起累积毒性。

Acrylates and methacrylates are detoxified predominantly via conjugation with glutathione via the Michael addition reaction or glutathione-S-transferase. They are also likely to be hydrolyzed via carboxylesterases. The lower molecular weight esters are rapidly metabolized and eliminated, therefore, will not likely cause cumulative toxicity.

来源:Hazardous Substances Data Bank (HSDB)

代谢

小量的甲基丙烯酸甲酯可以通过皂化作用轻易地代谢成醇和甲基丙烯酸。后者可以形成一个乙酰辅酶A衍生物，然后进入正常的脂质代谢。/甲基丙烯酸甲酯/

Small quantities of methacrylates may readily be metabolized by saponification into the alcohol & methacrylic acid. The latter may form an acetyl CoA derivative, which then enters the normal lipid metabolism. /Methacrylates/

来源:Hazardous Substances Data Bank (HSDB)

毒理性

暴露途径

该物质可以通过吸入其蒸汽被身体吸收。

The substance can be absorbed into the body by inhalation of its vapour.