3-(喹啉-4-基)丙-1-胺 | 379264-82-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 中文名称: 3-(喹啉-4-基)丙-1-胺
• 英文名称: 3-quinolin-4-ylpropylamine
• 英文别名: 3-(4-Quinolyl)propylamine；4-(3-aminopropyl)-quinoline；3-(quinolin-4-yl)propan-1-amine；3-quinolin-4-ylpropan-1-amine
• CAS: 379264-82-1
• 化学式: C₁₂H₁₄N₂
• 分子量: 186.257
• InChiKey: VEONADHCZDIKEW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  14
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  38.9
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  3-(喹啉-4-基)丙-1-胺 在 palladium dihydroxide acetate buffer 、 氢气 作用下， 以 乙醇 、 水 、 N,N-二甲基甲酰胺 、 甲苯 为溶剂， 反应 3.25h， 生成 2-[(E)-[(1R,2R,5R,7R,8R,9R,11R,13S,14R)-8-[(2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-2-ethyl-9-methoxy-1,5,7,9,11,13-hexamethyl-4,6,16-trioxo-3,15,17-trioxabicyclo[12.3.0]heptadecan-12-ylidene]amino]oxy-N-(3-quinolin-4-ylpropyl)acetamide
  参考文献：
  名称：

  A new type of ketolides bearing an N-aryl-alkyl acetamide moiety at the C-9 iminoether synthesis and structure–activity relationships

  摘要：

  A new type of ketolides, bearing an N-aryl-alkyl acetamide moiety at the C-9 iminoether and a cyclic carbonate at the G 11, 12 position was prepared and the antibacterial activities of the compounds were evaluated. Some of the derivatives showed potent antibacterial activity against both Haemophilus influenzae and Streptococcus pneumoniae, which are clinically important respiratory tract pathogens. Among the derivatives prepared, compound 5s with a quinolin-4-yl moiety was found to have potent and well-balanced activity against S. pneumoniae and H. influenzae including erythromycin-resistant strains. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2005.07.041
• 作为产物：
  描述：

  4-喹啉甲醛 在 二异丁基氢化铝 、 一水合肼 、 三苯基膦 、 苯甲酸 、 偶氮二甲酸二乙酯 作用下， 以 四氢呋喃 、 乙醇 、 甲苯 为溶剂， 反应 25.5h， 生成 3-(喹啉-4-基)丙-1-胺
  参考文献：
  名称：

  EP2287173

  摘要：

  公开号：

文献信息

• Tnf-alpha production inhibitors
  申请人：——

  公开号：US20030032623A1

  公开（公告）日：2003-02-13

  A purpose of the present invention is to provide TNF-&agr; production inhibitors being useful as therapeutic agents for autoimmune diseases such as rheumatoid arthritis. Novel compounds having the structure represented by the general formula [1] or salts thereof according to the present invention have excellent TNF-&agr; production inhibitory activities, 1 wherein “A” is —(NR 4 )—, —(CR 5 R 6 )— or —O—, “B” is alkylene or alkenylene, R 1 , R 2 , R 4 , R 5 and R 6 are hydrogen, alkyl, alkenyl, adamantyl or the like, R 3 is aryl or an unsaturated heterocycle, and “X” is oxygen or sulfer respectively.

  本发明的一个目的是提供作为类风湿性关节炎等自身免疫疾病治疗剂有用的TNF-α产生抑制剂。根据本发明具有由通式[1]表示的结构或其盐的新化合物具有出色的TNF-α产生抑制活性， 1 其中“A”为—(NR 4 )—，—(CR 5 R 6 )—或—O—，“B”为烷基或烯烃基，R 1 ，R 2 ，R 4 ，R 5 和R 6 为氢，烷基，烯烃基，金刚烷基或类似物，R 3 为芳基或不饱和杂环，而“X”分别为氧或硫。
• [EN] HYDROGEN BOND FORMING FLUORO KETOLIDES FOR TREATING DISEASES<br/>[FR] FLUOROCÉTOLIDES FORMANT DES LIAISONS HYDROGÈNE POUR TRAITER LES MALADIES
  申请人：CEMPRA PHARMACEUTICALS INC

  公开号：WO2012034058A1

  公开（公告）日：2012-03-15

  The invention described herein pertains to a novel macrolide antibacterial agent of formula (I): A-L-Q, as defined herein, and pharmaceutically acceptable salts, solvates, and hydrates thereof. Inter alia, the new macrolide antibacterial agent is active against a number of bacterial species, including resistant species.

  本发明涉及一种新型大环内酯抗菌药物，其化学式为(I)：A-L-Q，如本文所定义，并且其药用盐、溶剂合物和水合物。此外，这种新型大环内酯抗菌药物对多种细菌种类具有活性，包括耐药种类。
• Angiogenesis inhibitor
  申请人：Matsuoka Hidehito

  公开号：US20050014800A1

  公开（公告）日：2005-01-20

  An object of the present invention is to find new pharmacological actions of urea compounds having structure represented by the general formula [1]. The urea compounds having the structure represented by the general formula [1] have excellent angiogenesis inhibitory actions. [wherein “A” is —(NR 4 )—, —(CR 5 R 6 )— or —O—, “B” is alkylene or alkenylene, R 1 , R 2 , R 4 , R 5 and R 6 are hydrogen, alkyl, alkenyl, adamantylalkyl or the like, R 3 is aryl or an unsaturated heterocycle, and X is oxygen or sulfur.]

  本发明的目的是寻找具有一般式[1]所代表的结构的尿素化合物的新的药理作用。具有一般式[1]所代表的结构的尿素化合物具有出色的血管生成抑制作用。[其中“A”是-（NR4）-，-（CR5R6）-或-O-，“B”是烷基或烯基，R1，R2，R4，R5和R6为氢，烷基，烯基，金刚烷基或类似物，R3为芳香族或不饱和杂环，X为氧或硫。]
• TNF-a production inhibitors
  申请人：Ban Masakazu

  公开号：US20060229342A1

  公开（公告）日：2006-10-12

  A purpose of the present invention is to provide TNF-α production inhibitors being useful as therapeutic agents for autoimmune diseases such as rheumatoid arthritis. Novel compounds having the structure represented by the general formula [1] or salts thereof according to the present invention have excellent TNF-α production inhibitory activities, wherein “A” is —(NR 4 )—, —(CR 5 R 6 )— or —O—, “B” is alkylene or alkenylene, R 1 , R 2 , R 4 , R 5 and R 6 are hydrogen, alkyl, alkenyl, adamantyl or the like, R 3 is aryl or an unsaturated heterocycle, and “X” is oxygen or sulfer respectively.

  本发明的目的是提供一种TNF-α生产抑制剂，作为治疗自身免疫性疾病，如类风湿性关节炎的治疗剂。根据本发明，具有通式[1]表示的结构或其盐的新化合物具有优异的TNF-α生产抑制活性，其中“A”为—(NR4)—，—(CR5R6)—或—O—，“B”为烷基或烯基，“R1，R2，R4，R5和R6”为氢，烷基，烯基，金刚烷基或类似物，“R3”为芳基或不饱和杂环，而“X”分别为氧或硫。
• TNF-alpha production inhibitors
  申请人：Ban Masakazu

  公开号：US20080182881A1

  公开（公告）日：2008-07-31

  A purpose of the present invention is to provide TNF-α production inhibitors being useful as therapeutic agents for autoimmune diseases such as rheumatoid arthritis. Novel compounds having the structure represented by the general formula [1] or salts thereof according to the present invention have excellent TNF-α production inhibitory activities, wherein A is —(NR 4 )—, —(CR 5 R 6 )— or —O—, B is alkylene or alkenylene, R 1 , R 2 , R 4 , R 5 and R 6 are hydrogen, alkyl, alkenyl, adamantyl or the like, R 3 is aryl or an unsaturated heterocycle, and X is oxygen or sulfer respectively.

  本发明的目的是提供可用作治疗类风湿性关节炎等自身免疫疾病的TNF-α产生抑制剂。根据本发明，具有通式[1]所表示的结构或其盐的新化合物具有出色的TNF-α产生抑制活性，其中A为—(NR4)—、—(CR5R6)—或—O—，B为烷基或烯基烷基，R1、R2、R4、R5和R6为氢、烷基、烯基、金刚烷基或类似物，R3为芳基或不饱和杂环，X分别为氧或硫。